Living with Chronic Kidney Disease and Type 2 Diabetes Mellitus: The Patient and Clinician Perspective

Nicholas, Susanne B.; Wright, Eugene; Billings, Liana K.; Ambriz, Estela; Gee, Patrick; Peeler, Terry

doi:10.1007/s12325-022-02325-9

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…Intrinsic to a successful MDT–patient collaboration is a medical team who effectively communicate with, support, and educate their patients with diabetes about their personal CKD risk and CKD risk mitigation. It is essential that these communication strategies are implemented early following a diabetes diagnosis [ 17 ]. Communicating clearly that their risk can be reduced but not totally eliminated [ 17 ] is an important aspect of this.…”

Section: Multidisciplinary Team Approach To Chronic Kidney Disease Pr...mentioning

confidence: 99%

“…It is essential that these communication strategies are implemented early following a diabetes diagnosis [ 17 ]. Communicating clearly that their risk can be reduced but not totally eliminated [ 17 ] is an important aspect of this. There are several risk-reduction measures a patient with T2DM can use to reduce their risk of progressive CKD.…”

Section: Multidisciplinary Team Approach To Chronic Kidney Disease Pr...mentioning

confidence: 99%

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Optimizing Multidisciplinary Care of Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus

et al. 2023

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Diabetes is the leading cause of chronic kidney disease (CKD), a condition associated with significant morbidity and mortality. As these patients have a high risk of developing cardiovascular disease and end-stage kidney disease, there is a need for early detection and early initiation of appropriate therapeutic interventions that slow disease progression and prevent adverse outcomes. Due to the complex nature of diabetes and CKD management, a holistic, patient-centered, collaborative care approach delivered by a coordinated multidisciplinary team (ideally including a clinical pharmacist as part of a comprehensive medication management program) is needed. In this review, we discuss the barriers to effective care, the current multidisciplinary approach used for CKD prevention and treatment, and the potential ways that the multidisciplinary management of CKD associated with type 2 diabetes mellitus can be refined to improve patient outcomes.

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Section: Multidisciplinary Team Approach To Chronic Kidney Disease Pr...mentioning

confidence: 99%

Section: Multidisciplinary Team Approach To Chronic Kidney Disease Pr...mentioning

confidence: 99%

Optimizing Multidisciplinary Care of Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus

et al. 2023

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“…MDTs are associated with better care processes such as pharmacist–clinician collaborations [ 11 ] and reduced prescription errors [ 12 ]. Moreover, a patient-centric approach encourages patients to be active participants in their own care and may lead to better outcomes [ 13 ].…”

Section: Barriers To Effective Mdt Collaboration In Ckdmentioning

confidence: 99%

“…PCPs believe that a lack of CKD awareness and a lack of self-management skills among patients with CKD are barriers to optimal CKD management [ 15 ]. To overcome these literacy barriers, educational interventions involving concerted efforts across the MDT are needed [ 13 , 15 , 23 ]. For example, interventions such as a medicines use review (MUR) conducted by pharmacists in collaboration with patients aim to identify issues with non-adherence and increase patient understanding of their medicines [ 27 ].…”

Section: Barriers To Providing Effective Care and Support To Patients...mentioning

confidence: 99%

Optimizing Collaborative Care of Patients with Chronic Kidney Disease Associated with Type 2 Diabetes: An Example Practice Model at a Health Care Practice in Kentucky, United States

Gatlin,

Miller,

Chang

2023

Diabetes Ther

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Suboptimal multidisciplinary team collaboration is a barrier to effective health care provision for patients with chronic kidney disease (CKD) associated with type 2 diabetes mellitus (T2DM). We describe an example practice model of a clinical practice called Baptist Health Deaconess, based in Madisonville, Kentucky, USA, where a small multidisciplinary team consisting of an endocrinologist, nurse practitioner, and pharmacist (authors of this article) work collaboratively in an ambulatory care setting to provide health care to the patients they serve. Many of the patients who receive care at Baptist Health Deaconess are on a low income, have poor health literacy, and do not have a primary care physician. The presence of a pharmacist in the team allows for insurance/access investigations to assess drug choice and affordability; such aspects can be performed quickly with a pharmacist in the office.

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“…Chronic kidney disease (CKD) and Metabolic dysfunction-associated steatotic liver disease (MASLD) are associated with obesity, type 2 diabetes, and metabolic syndrome [ 1 , 2 ]. The possible association between MASH and CKD remains poorly understood [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics

Moreno,

Gluud,

Galsgaard

et al. 2024

PLoS ONE

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Background Chronic Kidney Disease (CKD) and Metabolic dysfunction-associated steatohepatitis (MASH) are metabolic fibroinflammatory diseases. Combining single-cell (scRNAseq) and spatial transcriptomics (ST) could give unprecedented molecular disease understanding at single-cell resolution. A more comprehensive analysis of the cell-specific ligand-receptor (L-R) interactions could provide pivotal information about signaling pathways in CKD and MASH. To achieve this, we created an integrative analysis framework in CKD and MASH from two available human cohorts. Results The analytical framework identified L-R pairs involved in cellular crosstalk in CKD and MASH. Interactions between cell types identified using scRNAseq data were validated by checking the spatial co-presence using the ST data and the co-expression of the communicating targets. Multiple L-R protein pairs identified are known key players in CKD and MASH, while others are novel potential targets previously observed only in animal models. Conclusion Our study highlights the importance of integrating different modalities of transcriptomic data for a better understanding of the molecular mechanisms. The combination of single-cell resolution from scRNAseq data, combined with tissue slide investigations and visualization of cell-cell interactions obtained through ST, paves the way for the identification of future potential therapeutic targets and developing effective therapies.

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Living with Chronic Kidney Disease and Type 2 Diabetes Mellitus: The Patient and Clinician Perspective

Cited by 5 publications

References 24 publications

Optimizing Multidisciplinary Care of Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus

Optimizing Multidisciplinary Care of Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus

Optimizing Collaborative Care of Patients with Chronic Kidney Disease Associated with Type 2 Diabetes: An Example Practice Model at a Health Care Practice in Kentucky, United States

Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics

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