Living Unrelated Renal Transplantation for Sickle Cell Nephropathy

Brennan, Daniel C.; Lippmann, Bruce J.; Shenoy, Surendra; Lowell, Jeffrey A.; Howard, Todd K.; Flye, M. Wayne

doi:10.1097/00007890-199503150-00029

Cited by 8 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 Kidney transplantation has been the most common procedure for patients with SCD-related disease. 8,9,[11][12][13][14][15][16] The main challenges of solid-organ transplantation in patients with SCD relate to higher perioperative mortality and risk of graft loss due to vaso-occlusive complications in the transplanted organ. Major surgery in SCD poses a risk of acute vaso-occlusive complications, such as the development of acute chest syndrome, a life-threatening acute lung injury syndrome characterized by bilateral ra- diographic infiltrates, fever, and hypoxemia.…”

Section: Discussionmentioning

confidence: 99%

“…22 In renal transplantation, some have recommended more stringent preoperative transfusion goals to minimize or even eliminate HbS. 8,9 Furthermore, there have been associations between HbS percentage and disease severity in other reported complications of SCD. 23 The optimal target hematocrit and HbS percentage are debated, however, as frequent blood transfusions are not without risk.…”

Section: Discussionmentioning

confidence: 99%

“…In preparation for listing, an extremely conservative hematologic goal of less than 10% HbS was set to prevent sickle cell crisis at the time of transplant and postoperatively. [7][8][9] The patient underwent weekly blood transfusions, continuing his deferasirox, hydroxyurea, and enoxaparin anticoagulation. Once he reached the target hemoglobin, he was listed in October 2010 for double lung transplantation.…”

Section: Case Descriptionmentioning

confidence: 99%

See 2 more Smart Citations

First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease

et al. 2013

View full text Add to dashboard Cite

Abstract:Little is known about the use of lung transplantation in the management of sickle cell diseaseassociated pulmonary arterial hypertension (SCD-PAH). We present clinical and pathological data and report the first successful outcome of bilateral lung transplantation in a patient with severe SCD-PAH and pulmonary veno-occlusive disease (PVOD). We discuss the complexities of multidisciplinary planning and management of lung transplantation in patients with SCD-associated pulmonary vascular complications. This case reports the first documented successful lung transplant and first case of PVOD in a patient with SCD-PAH.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Case Descriptionmentioning

confidence: 99%

See 1 more Smart Citation

First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Brennan and associates [36] proposed a protocol after a successful living-unrelated transplant at their center. They suggested preoperative transfusion until sickle cell preparation is negative, use of antithymocyte globulin on induction, and use of hydroxyurea in preference of azathioprine with the dual purpose of immunosuppression and stimulation of fetal hemoglobin [36].…”

Section: Outcome Of Kidney Transplant In Scdmentioning

confidence: 99%

“…They suggested preoperative transfusion until sickle cell preparation is negative, use of antithymocyte globulin on induction, and use of hydroxyurea in preference of azathioprine with the dual purpose of immunosuppression and stimulation of fetal hemoglobin [36]. In a review by Scheinman [37], warming the graft with saline at 37°C, along with infusion of dopamine at 4 μ g/kg/min during and after transplant, was advocated.…”

Section: Outcome Of Kidney Transplant In Scdmentioning

confidence: 99%

Outcome and Challenges of Kidney Transplant in Patients with Sickle Cell Disease

Okafor

Aneke

2013

Journal of Transplantation

View full text Add to dashboard Cite

Sickle cell nephropathy is a common presentation in patients with sickle cell disease. End-stage kidney disease is the most severe presentation of sickle cell nephropathy in terms of morbidity and mortality. Sickle cell disease patients with end-stage kidney disease are amenable to renal replacement therapy including kidney transplant. Kidney transplant in these patients has been associated with variable outcome with recent studies reporting short- and long-term outcomes comparable to that of patients with HbAA. Sickle cell disease patients are predisposed to various haematological, cardiorespiratory, and immunological challenges. These challenges have the potential to limit, delay, or prevent kidney transplant in patients with sickle cell disease. There are few reports on the outcome and challenges of kidney transplant in this group of patients. The aim of this review is to highlight the outcome and challenges of kidney transplant in patients with sickle cell disease.

show abstract

Transplantation in Inherited, Systemic, and Metabolic Diseases

Lederer

1998

Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS

View full text Add to dashboard Cite

Living Unrelated Renal Transplantation for Sickle Cell Nephropathy

Cited by 8 publications

References 0 publications

First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease

First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease

Outcome and Challenges of Kidney Transplant in Patients with Sickle Cell Disease

Transplantation in Inherited, Systemic, and Metabolic Diseases

Contact Info

Product

Resources

About