Living systematic reviews, not only for clinical (placebo) research

Enck, Paul

doi:10.1016/j.jclinepi.2018.01.001

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The origin of the Journal of Interdisciplinary Placebo Studies (JIPS) database has been described previously (Colloca et al, 2016;Enck, 2018). Instead of a complex search algorithm, the search term "placebo" is applied to the PubMed metadatabase, resulting in between 150 and 250 new citations per week that are screened for relevance for placebo research.…”

Section: Methodsmentioning

confidence: 99%

The Placebo and Nocebo Responses in Clinical Trials in Inflammatory Bowel Diseases

Enck¹,

Klosterhalfen²

2021

Front. Pharmacol.

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Placebo and nocebo responses are mostly discussed in clinical trials with functional bowel disorders. Much less has been investigated and is known in gastrointestinal diseases beyond irritable bowel syndrome (IBS), especially in inflammatory bowel diseases (IBD). For the purpose of this review, we screened the Journal of Interdisciplinary Placebo Studies (JIPS) database with approximately 4,500 genuine placebo research articles and identified nine meta-analyses covering more than 135 randomized and placebo-controlled trials (RCTs) with more than 10,000 patients with Crohn´s disease (CD) and another five meta-analyses with 150 RCTs and more than 10,000 patients with ulcerative colitis (UC). Only three discussed nocebo effects, especially in the context of clinical use of biosimilars to treat inflammation. The articles were critically analyzed with respect to the size of the placebo response in CD and UC, its effects on clinical improvement versus maintenance of remission, and mediators and moderators of the response identified. Finally, we discussed and compared the differences and similarities of the placebo responses in IBD and IBS and the nocebo effect in switching from biologics to biosimilars in IBD management.

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Section: Methodsmentioning

confidence: 99%