Living organisms influence on environmental conditions: pH modulation by amphibian embryos versus aluminum toxicity

Herkovits, Jorge; Castañaga, Luis A.; D'Eramo, José L.; Jourani, Victoria Platonova

doi:10.1016/j.chemosphere.2015.05.025

Cited by 7 publications

(4 citation statements)

References 46 publications

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“…This study confirms the ability of aluminium to cause toxic effects to developing organisms causing death and phenotypic changes according to what has been shown in amphibians and fish (O guz et al 2012;Herkovits et al 2015). Of interest is the observation of the higher toxicity of aluminium in the larval stages than in the embryo stages, an action probably due to the absence of the chorion in larvae and that in the early stages of development it exerts a good protection for the embryo.…”

Section: Discussionsupporting

confidence: 90%

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Aluminium chloride‐induced toxicity in zebrafish larvae

Antonio

Grimaldi

Ferrandino

2016

Journal of Fish Diseases

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Embryos at shield stage and larvae at protruding mouth stage were exposed to different concentrations of aluminium chloride (AlCl ) for 72 h with the purpose to analyse their phenotype and lethality. After 24, 48 and 72 h of treatment, higher toxicity of the metal was observed on larvae with minimal lethal concentration of 0.25, 0.20 and 0.08 mm, respectively, while for embryos the corresponding values were 40, 25 and 16 mm. We observed pericardial oedema and alteration of heart rate in 50% of larvae after 48 h of exposure to 100 μm. In larvae exposed to the same concentration, there was also a neurological injury at the level of glial cells, with the number of glial fibrillary acidic protein-positive cells being significantly reduced. This study confirms the toxic nature of this metal and shows that aluminium could also interestingly represent a cardiotoxin in addition to its neurotoxic ability.

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Section: Discussionsupporting

confidence: 90%

“…; Herkovits et al . ). Of interest is the observation of the higher toxicity of aluminium in the larval stages than in the embryo stages, an action probably due to the absence of the chorion in larvae and that in the early stages of development it exerts a good protection for the embryo.…”

Section: Discussionmentioning

confidence: 97%

Aluminium chloride‐induced toxicity in zebrafish larvae

Antonio

Grimaldi

Ferrandino

2016

Journal of Fish Diseases

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“…Since the impacts of humanity on the biosphere [27] and materials [28] quantity and diversity, we have the challenge of reducing environmental toxicity due to its deleterious effects on the ecosystem and human health, including preventing the next pandemic from more devastating effects. Living organisms, even vertebrate embryos, exhibit an enormous capacity to modify environmental toxicity toward conditions favorable to life [29]. Thus, limiting the discharge of toxic materials in the ecosystem will provide an opportunity for a myriad of species to survive and participate in building resilience and enhancing auto-depuration processes, constructing and maintaining a life reservoir in the ecosystem.…”

Section: Sentinel Organisms For the Basic Environment And Human Healt...mentioning

confidence: 99%

One Health: potential synergy between infectious and toxic agents. The case of COVID-19

Herkovits

2023

Academia Medicine

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Although the relationship between environmental toxicity and infectious diseases is poorly studied, it is probably more common than is recognized, since the chemical substances could be associated with pre-existing pathologies. For example, some conditions that influence the progression of COVID-19 could have toxicological causes such as cancer, endocrine, neurological, and inflammatory disorders, kidney failure, etc. This contribution highlights that SARS-CoV-2 and some high-volume organic and inorganic chemicals could also exert dysfunctions in the same homeostatic regulators such as HIF-1 and ACE2, with a potential synergistic effect that could affect the severity of COVID-19. This potential synergy is illustrated with adverse effects acquired through bioassays performed with free-living vertebrate embryos indicating that their use as sentinel organisms for environmental contamination could be beneficial both for the ecosystem and human health.

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“…While Al exposure is recognised to reduced survival, reproduction, and growth rates in fish and amphibians [ 10 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ], only a few studies have addressed the neurotoxicity impacts in aquatic vertebrates. However, damages to the nervous system could alter the relational functions of organisms, threatening their survival, reproduction, and, ultimately, the population dynamics.…”

Section: Introductionmentioning

confidence: 99%

Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review

Closset

Cailliau

Slaby

et al. 2021

IJMS

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Aluminium (Al) is the most common natural metallic element in the Earth’s crust. It is released into the environment through natural processes and human activities and accumulates in aquatic environments. This review compiles scientific data on the neurotoxicity of aluminium contamination on the nervous system of aquatic organisms. More precisely, it helps identify biomarkers of aluminium exposure for aquatic environment biomonitoring in freshwater aquatic vertebrates. Al is neurotoxic and accumulates in the nervous system of aquatic vertebrates, which is why it could be responsible for oxidative stress. In addition, it activates and inhibits antioxidant enzymes and leads to changes in acetylcholinesterase activity, neurotransmitter levels, and in the expression of several neural genes and nerve cell components. It also causes histological changes in nerve tissue, modifications of organism behaviour, and cognitive deficit. However, impacts of aluminium exposure on the early stages of aquatic vertebrate development are poorly described. Lastly, this review also poses the question of how accurate aquatic vertebrates (fishes and amphibians) could be used as model organisms to complement biological data relating to the developmental aspect. This “challenge” is very relevant since freshwater pollution with heavy metals has increased in the last few decades.

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Living organisms influence on environmental conditions: pH modulation by amphibian embryos versus aluminum toxicity

Cited by 7 publications

References 46 publications

Aluminium chloride‐induced toxicity in zebrafish larvae

Aluminium chloride‐induced toxicity in zebrafish larvae

One Health: potential synergy between infectious and toxic agents. The case of COVID-19

Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review

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