Living histamine-containing cells from the bronchial lumens of humans. Description and comparison of histamine content with cells of rhesus monkeys.

Patterson, Roy; McKenna, J.; Suszko, Irena M.; Solliday, Norman H.; Pruzansky, Jacob J.; Roberts, Mary; Kehoe, Thomas J.

doi:10.1172/jci108631

Cited by 70 publications

(13 citation statements)

References 9 publications

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“…Histamine-containing cells have been demon strated in bronchial secretions [9][10][11], and histamine release from these cells can be induced by a variety of stimuli. IgE-mediated release of histamine into nasal secretions [12] might be expected to occur in patients with allergic rhinitis.…”

mentioning

confidence: 99%

Histamine in Nasal Secretions and Serum May Be Elevated during Viral Respiratory Tract Infections

Smith¹,

Remigio²

1982

Int Arch Allergy Immunol

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This study investigated histamine concentration in nasal secretions from children who had viral respiratory tract infection. It demonstrated that (1) there may be appreciable histamine in nasal secretions during viral respiratory tract infection; (2) concentration of histamine in serum may be elevated at the same time; and (3) children with past medical or family history of atopy had more histamine in nasal secretions during viral infections than did nonatopic children.

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mentioning

confidence: 99%

Histamine in Nasal Secretions and Serum May Be Elevated during Viral Respiratory Tract Infections

Smith¹,

Remigio²

1982

Int Arch Allergy Immunol

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“…Basophilic leukocytes occur in the peri pheral blood of rh esu s monkey but with great infrequency (less than 0.1 °/o) [12]. This low frequency resulted in our failure to detect them with electron microscopy in the current study.…”

Section: Discussionmentioning

confidence: 69%

“…Mature human basophilic leuko cytes are multinucleated. Light-microscopic examinations of monkey basophilic leuko cytes also showed multilobulation of the nu cleus [12,13],…”

Section: Discussionmentioning

confidence: 99%

Histamine-Containing Cells in Bronchial Lavage Fluid

Ts’ao¹,

Metzger²,

Patterson³

et al. 1976

Int Arch Allergy Immunol

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We have studied the ultrastructure of histamine-containing cells in the bronchial lavage of normal rhesus monkeys. These cells were recognized by the similarities of their specific cytoplasmic granules to those in tissue mast cells and basophilic leukocytes of other species. According to cell shape, two forms of bronchial lavage histamine-containing cells (BL-HCC) were observed. One was round and small, and the other pleomorphic and large. However, the subcellular structures, especially the specific cytoplasmic granules, were identical for both forms of HCC. With available evidence, we now consider both types of BL-HCC to be one cell species. The difference in cell shape may be an inherent variation within this cell population, or a reflection of the maturity of individual cells. Most BL-HCC had long slender pseudopods, and the majority of them were mononucleated. Some HCC appeared binucleated; multinucleated cells were not encountered. The ultrastructure of mast cells, in tissue fragments biopsied from three sites, was in many ways similar to that of BL-HCC, but there were clear morphological dissimilarities between these two cell groups. It is unlikely that tissue mast cells are the direct precursors of BL-HCC. Attempts to compare BL-HCC with blood basophilic leukocytes were unsuccessful due to the failure to detect the latter in monkey peripheral blood with electron microscopy in the present study. The possible origin of BL-HCC is discussed.

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“…Mast or basophil-like cells could be identified in the la vage of rhesus monkeys and could be stim ulated to release histamine in response to IgE-dependent challenge [Patterson et al, 1976b], Transfer of such bronchial lumen cells from an Ascaris-sensitive donor to a non-allergic recipient transferred an anti gen-specific bronchial reaction [Patterson et al, 1978]. Early experiments with bron chial lavage in human subjects recovered mast cells (0.3-0.7% of total cells) from the bronchial lumen, but functional studies were complicated by poor viability and high rates of spontaneous histamine re lease [Patterson et al, 1977].…”

Section: Human Bronchoalveolar Mast Cellsmentioning

confidence: 99%

The Function and Properties of Human Lung Mast Cells

Flint

Leung²,

Hudspith

et al. 1986

Respiration

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Mast cells may be recovered from human subjects by bronchoalveolar lavage. Such bronchoalveolar mast cells will release histamine in response to IgE-dependent challenge in a reaction that is dose-, time- and energy-dependent. They possess functional characteristics distinct from dispersed human lung mast cells. The percentage of mast cells within the bronchoalveolar cell population is critically dependent upon the underlying pathology. Greater numbers of mast cells may be recovered from the bronchoalveolar compartment of extrinsic asthmatics than from controls. In addition, bronchoalveolar mast cells from asthmatic subjects show an increased releasability of histamine in response to anti-IgE. Antigen challenge also leads to the release of histamine in vitro, demonstrating the potential for the antigen-specific initiation of bronchoconstriction in these subjects. Spontaneous release of histamine from bronchoalveolar mast cells of asthmatic subjects was also greater than in controls (up to 46%), a feature which may be related to non-immunological mechanisms of bronchoconstriction. Such non-immunological mechanisms have been further investigated utilising mannitol as a model of hyperosmolar histamine release. Mannitol induced a dose-dependent release of histamine from bronchoalveolar mast cells of normal subjects, and this release was significantly inhibited by sodium cromoglycate. The leukotrienes are putative major mediators of human asthma. After challenge with anti-IgE in vitro, dose-dependent release of leukotriene C4 and prostaglandin D2 occurs from the bronchoalveolar cells of normal subjects. The release of PGD2 shows significant correlation with histamine release. Lying superficially, bronchoalveolar mast cells would be readily accessible to inhaled antigen. Mediator release from such cells may be relevant to the pathogenesis of asthma.

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Living histamine-containing cells from the bronchial lumens of humans. Description and comparison of histamine content with cells of rhesus monkeys.

Cited by 70 publications

References 9 publications

Histamine in Nasal Secretions and Serum May Be Elevated during Viral Respiratory Tract Infections

Histamine in Nasal Secretions and Serum May Be Elevated during Viral Respiratory Tract Infections

Histamine-Containing Cells in Bronchial Lavage Fluid

The Function and Properties of Human Lung Mast Cells

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