Living Electrospun Short Fibrous Sponge via Engineered Nanofat for Wound Healing

Fu, Xiaohan; Wang, Juan; Qian, Dejian; Chen, Zhaowen; Chen, Liang; Cui, Wenguo; Wang, Yan

doi:10.1007/s42765-022-00229-5

Cited by 33 publications

(13 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results from different experiments did not prove that the pro‐coagulation of that hemostatic sponge reported by Xie et al was superior to that of the short fibers in our study, which is closely related to the concentration of Ca 2+ added to whole blood and the degree of blood activation. The hemostatic sponge in that report was prepared by electrostatic spinning with a fiber diameter of ≈683 ± 147 nm (similar to the report [ 20 ] ), the short fibers derived from bacterial nanocellulose in this report possessed nanofiber with diameter less than 100 nm, [ 18 ] which proved that a significantly larger specific surface area for our short fibers when contacted with blood. Moreover, the report demonstrated that the whole blood clotting rate of OBNC short fibers was faster than that of collagen hemostatic sponges used in commercial, [ 16 ] indicating that the short fibers in this report have superior whole blood clotting effect.…”

Section: Resultssupporting

confidence: 72%

Bacteriosynthetic Degradable Tranexamic Acid‐Functionalized Short Fibers for Inhibiting Invisible Hemorrhage

Bao

Zhang

et al. 2023

Small

Self Cite

View full text Add to dashboard Cite

Current research on hemostatic materials have focused on the inhibition of visible hemorrhage, however, invisible hemorrhage is the unavoidable internal bleeding that occurs after trauma or surgery, leading directly to a dramatic drop in hemoglobin and then to anemia and even death. In this study, bacterial nanocellulose (BNC) was synthesized and oxidized from the primary alcohols to carboxyl groups, and then grafted with tranexamic acid through amide bonds to construct degradable nanoscale short fibers (OBNC‐TXA), which rapidly activated the coagulation response. The hemostatic material is made up of nanoscale short fibers that can be constructed into different forms such as emulsions, gels, powders, and sponges to meet different clinical applications. In the hemostatic experiments in vitro, the composites had significantly superior pro‐coagulant properties due to the rapid aggregation of blood cells. In the coagulation experiments with rat tail amputation and liver trauma hemorrhage models, the group treated with OBNC‐TXA1 sponge showed low hemorrhage and inhibited invisible hemorrhage in rectus abdominis muscle defect hemorrhage models, with a rapid recovery of hemoglobin values from 128±5.5 to 165±2.6 g L−1 within 4 days. In conclusion, the degradable short fibers constructed from bacterial nano‐cellulose achieved inhibition of invisible hemorrhage in vivo.

show abstract

Section: Resultssupporting

confidence: 72%

Bacteriosynthetic Degradable Tranexamic Acid‐Functionalized Short Fibers for Inhibiting Invisible Hemorrhage

Bao

Zhang

et al. 2023

Small

Self Cite

View full text Add to dashboard Cite

show abstract

“…[25] Following the integration of PDA NPs into PAN fiber, a new peak was seen at 1630 cm −1 , which is ascribed to the aromatic ring's C=C stretching vibration. The stretching vibration of catechol O─H and N─H causes the peak at 3451 cm −1 to become more intense [26] (Figure 1I). The variation in peak position and intensity illustrates the successful incorporation of PDA NPs into the PAN layer.…”

Section: Design and Characterization Of Janus Nanofiber Membranesmentioning

confidence: 99%

Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

Zhang,

Yu,

Ren

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Diabetic wounds are difficult to heal, and the key to wound healing is exudate management and effective disinfection. Inspired by the asymmetric wettability of Janus‐structured lotus leaves, herein the study has presented the design of a biomimetic asymmetric Janus membrane that integrates unidirectional biofluid drainage and photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic wound healing. This Janus membrane is prepared by electrospinning polyacrylonitrile (PAN) nanofiber membrane containing polydopamine (PDA) on the surface of polypropylene (PP) nonwoven membrane. Such PP/PANx%PDA Janus membrane enables antigravity “pumping” of the water from the hydrophobic PP layer to the hydrophilic PANx%PDA layer within 22 s through contact points on the Janus interface. The incorporation of 30 wt% PDA in PAN imparts high photoabsorption and photothermal responsiveness, facilitating continuous volatilization of the exudate, achieving twice the displacement of water, and causing irreversible damage to bacteria. As a result, it effectively alleviates inflammation and cellular fibrosis while promoting collagen deposition due to its structure and antibacterial properties. Impressively, such photothermal‐enhanced Janus membrane achieves an impressive closure rate of 96.7% for diabetic wounds, better than that of (59.8%) for conventional bandages. Therefore, this asymmetric Janus membrane offers a promising alternative for the healing of chronic diabetic wounds.

show abstract

“…Oxygen is an indispensable feature of respiration in almost all forms of living organisms and is part of the building blocks of life. [46,51] The accurate detection of oxygen has significant ramifications for both domestic and industrial applications, especially in the food, pharmaceutical, and underground exploration industries. [52,53] Over the years, chromogenic methods have been adopted for semiquantitative analysis, such as blood glucose, NO 3 − in water, pH, or CO 2 /O 2 .…”

Section: Single-/multicolor Transitioning Filmsmentioning

confidence: 99%

N‐Doped Carbon‐Quantum‐Dot‐Integrated Colorimetric System for Visible Photoprinting and Oxygen Sensing

Liu,

Wen

et al. 2024

Advanced Optical Materials

View full text Add to dashboard Cite

The design of light‐responsive color switching systems (LCSs) is essential to the implementation of rewritable paper and oxygen detection. Previous LCSs rely on metal‐based semiconductor photocatalysts which are expensive and pose metal‐leaking risk. To solve the issue, for the first time, nitrogen‐doped carbon quantum dots (N‐CQDs) are reported as metal‐free photocatalyst for visible photoprinting and oxygen sensing. On N‐CQD surface, the decorated amino and hydroxyl groups act as hole scavengers and thus realize visible‐light‐responsive single and multiple color switching, after mixing with redox‐sensitive dyes. Combined with polymeric substrates, LCS rewritable papers can be fabricated and exhibit rapid decoloration performances under 420 nm light irradiation, due to the reduction of dye by photogenerated electrons from N‐CQDs. After the decoloration, efficient color reversion can be realized by the oxidization of dye in ambient air (O2). By taking advantage of the controlled recoloration kinetics, an oxygen sensor can be attained for visual quantitative analysis of atmospheric conditions with color variations. These results assist the future development of nonmetal color switching systems for superior functional design of photoprintable papers and colorimetric oxygen sensors.

show abstract

Living Electrospun Short Fibrous Sponge via Engineered Nanofat for Wound Healing

Cited by 33 publications

References 56 publications

Bacteriosynthetic Degradable Tranexamic Acid‐Functionalized Short Fibers for Inhibiting Invisible Hemorrhage

Bacteriosynthetic Degradable Tranexamic Acid‐Functionalized Short Fibers for Inhibiting Invisible Hemorrhage

Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

N‐Doped Carbon‐Quantum‐Dot‐Integrated Colorimetric System for Visible Photoprinting and Oxygen Sensing

Contact Info

Product

Resources

About