Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients

Broers, Natascha J. H.; Fung, Tsz Yeung; Kooman, Jeroen P.; Christiaans, Maarten H. L.

doi:10.1186/s12882-019-1299-9

Cited by 11 publications

(4 citation statements)

References 42 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Muscle strength appears to be a more powerful predictor for the outcome as compared to MM (65). Furthermore, following renal transplantation, we observed a profound increase in HGS without a significant increase in LTM (66).…”

Section: The Role Of Estimation Of MM In the Integrated Functional Assessment Of Patients On Krtmentioning

confidence: 54%

Estimation of Muscle Mass in the Integrated Assessment of Patients on Hemodialysis

et al. 2021

Self Cite

View full text Add to dashboard Cite

Assessment of muscle mass (MM) or its proxies, lean tissue mass (LTM) or fat-free mass (FFM), is an integral part of the diagnosis of protein-energy wasting (PEW) and sarcopenia in patients on hemodialysis (HD). Both sarcopenia and PEW are related to a loss of functionality and also increased morbidity and mortality in this patient population. However, loss of MM is a part of a wider spectrum, including inflammation and fluid overload. As both sarcopenia and PEW are amendable to treatment, estimation of MM regularly is therefore of major clinical relevance. Whereas, computer-assisted tomography (CT) or dual-energy X-ray absorptiometry (DXA) is considered a reference method, it is unsuitable as a method for routine clinical monitoring. In this review, different bedside methods to estimate MM or its proxies in patients on HD will be discussed, with emphasis on biochemical methods, simplified creatinine index (SCI), bioimpedance spectroscopy (BIS), and muscle ultrasound (US). Body composition parameters of all methods are related to the outcome and appear relevant in clinical practice. The US is the only parameter by which muscle dimensions are measured. BIS and SCI are also dependent on either theoretical assumptions or the use of population-specific regression equations. Potential caveats of the methods are that SCI can be influenced by residual renal function, BIS can be influenced by fluid overload, although the latter may be circumvented by the use of a three-compartment model, and that muscle US reflects regional and not whole body MM. In conclusion, both SCI and BIS as well as muscle US are all valuable methods that can be applied for bedside nutritional assessment in patients on HD and appear suitable for routine follow-up. The choice for either method depends on local preferences. However, estimation of MM or its proxies should always be part of a multidimensional assessment of the patient followed by a personalized treatment strategy.

show abstract

Section: The Role Of Estimation Of MM In the Integrated Functional Assessment Of Patients On Krtmentioning

confidence: 54%

Estimation of Muscle Mass in the Integrated Assessment of Patients on Hemodialysis

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Renal transplantation is the most mature and reliable method for the treatment of ESRD, which could effectively improve the quality of life and survival time of patients (18). However, the long-term survival of allogeneic renal transplantation remained unsatisfactory (19).…”

Section: Discussionmentioning

confidence: 99%

Identification of CD2, CCL5 and CCR5 as potential therapeutic target genes for renal interstitial fibrosis

Zhang¹,

Hu²,

Feng³

et al. 2019

Ann. Transl. Med.

View full text Add to dashboard Cite

Background: We aimed to explore potential gene biomarkers of renal interstitial fibrosis (RIF) due to a lack of effective and non-invasive methods for diagnosis.Methods: Three data sets (GSE22459, GSE76882 and GSE57731) including 350 samples were acquired from Gene Expression Omnibus (GEO) database. We used bioconductor limma package to perform background adjustment. Cluster analysis was conducted by 'edgeR' package to identify the differentially expressed genes (DEGs). We generated heat maps with using heatmap package in R software. Function annotation of genes was performed by Gene Ontology (GO) enrichment analysis. STRING (Search Tool for the Retrieval of Interacting Genes) database was employed to construct the protein-protein interaction (PPI) network and the results were visualized by Cytoscape 3.6.1. At last, we applied Graphpad Prism 7.0. to explore the correlation between three hub genes and pathological degrees of RIF.Results: By applying the "edgeR" package in R, we detected 116 DEGs with three data sets. These genes were enriched in 19 GO biological process categories. Three main hub genes (CD2, CCL5 and CCR5) were identified after construction of PPI network. In Pearson correlation coefficient, CD2, CCL5 and CCR5 was found to hold higher expression patterns in RIF samples based on independent data set GSE57731. Besides, their gene expression levels were found significantly positive correlation with the degree of RIF (CD2:

show abstract

“…These studies were conducted between February 2012 and July 2017, and between October 2013 and January 2018), respectively. The methodology of the individual studies has been published previously [33,34]. A complete overview of in- and exclusion criteria of these studies is also provided in S1 Methods.…”

Section: Methodsmentioning

confidence: 99%

Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background Cardiovascular disease (CVD) related mortality and morbidity are high in end-stage renal disease (ESRD). The pathophysiology of CVD in ESRD may involve non-traditional CVD risk factors, such as accumulation of advanced glycation endproducts (AGEs), dicarbonyls, endothelial dysfunction (ED) and low-grade inflammation (LGI). However, detailed data on the relation of AGEs and dicarbonyls with ED and LGI in ESRD are limited. Methods We examined cross-sectional Spearman’s rank correlations of AGEs and dicarbonyls with serum biomarkers of ED and LGI in 43 individuals with chronic kidney disease (CKD) stage 5 not on dialysis (CKD5-ND). Free and protein-bound serum AGEs ( N ∈ -(carboxymethyl)lysine (CML), N ∈ -(carboxyethyl)lysine (CEL), N δ -(5-hydro-5-methyl-4-imidazolon-2-yl)ornithine (MG-H1)) and serum dicarbonyls (glyoxal, methylglyoxal, 3-deoxyglucosone) were analyzed with tandem mass spectrometry, and tissue AGE accumulation was estimated by skin autofluorescence (SAF). Further, serum biomarkers of ED and LGI included sVCAM-1, sE-selectin, sP-selectin, sThrombomodulin, sICAM-1, sICAM-3, hs-CRP, SAA, IL-6, IL-8 and TNF-α. Results After adjustment for age, sex and diabetes status, protein-bound CML was positively correlated with sVCAM-1; free CEL with sVCAM-1 and sThrombomodulin; glyoxal with sThrombomodulin; and methylglyoxal with sVCAM-1 (correlation coefficients ranged from 0.36 to 0.44). In addition, free CML was positively correlated with SAA; protein-bound CML with IL-6; free CEL with hs-CRP, SAA and IL-6; free MG-H1 with SAA; protein-bound MG-H1 with IL-6; and MGO with hs-CRP and IL-6 (correlation coefficients ranged from 0.33 to 0.38). Additional adjustment for eGFR attenuated partial correlations of serum AGEs and serum dicarbonyls with biomarkers of ED and LGI. Conclusions In individuals with CKD5-ND, higher levels of serum AGEs and serum dicarbonyls were related to biomarkers of ED and LGI after adjustment for age, sex and diabetes mellitus. Correlations were attenuated by eGFR, suggesting that eGFR confounds and/or mediates the relation of serum AGEs and dicarbonyls with ED and LGI.

show abstract

Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients

Cited by 11 publications

References 42 publications

Estimation of Muscle Mass in the Integrated Assessment of Patients on Hemodialysis

Estimation of Muscle Mass in the Integrated Assessment of Patients on Hemodialysis

Identification of CD2, CCL5 and CCR5 as potential therapeutic target genes for renal interstitial fibrosis

Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study

Contact Info

Product

Resources

About