Living donor transplant options in end-stage renal disease patients with ABO incompatibility

Waigankar, S.; Kamat, Madhav; Joshi, S. S.; Gandhi, Bhupendra; Bahadur, Madan M.; Deshpande, Rushi

doi:10.4103/0970-1591.114031

Cited by 8 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 7 5 ] Similarly, excellent patient survival rate was seen in other studies by Waigankar et al . (100%)[ 8 ] and Kute et al . (94.64%).…”

Section: Discussionmentioning

confidence: 99%

Paired kidney exchange transplantation: Maximizing the donor pool

P¹,

Sethi²,

Bansal³

et al. 2015

Indian J Nephrol

View full text Add to dashboard Cite

In the last decade, paired kidney exchange (PKE) transplantation has gained popularity worldwide as a viable alternative for end stage renal disease (ESRD) patients who have incompatible or sensitized donors. This study presents our experience with PKE transplantation and compares outcome between PKE and non-PKE renal transplant recipients. Between February 2010 and November 2013, 742 transplants were performed, of which 26 (3.5%) were PKE transplantations. All were two-way exchanges. PKE recipients were significantly older than non-PKE (46.73 ± 9.71 vs. 40.08 ± 13.36 years; P = 0.012) while donor ages were comparable. PKE patients had significantly higher number of HLA mismatches (5.03 ± 1.14 vs. 3.49 ± 1.57; P < 0.0001). After a median follow-up of 20 months (range: 3–47 months), there was no significant difference in patient survival (PKE 96.16% vs. non-PKE 96.65%; P = 0.596) and death censored graft survival (PKE 96.16% vs. non-PKE 96.37%; P = 1). Mean serum creatinine at 1 month and at last follow-up was lower in PKE versus non-PKE group (0.98 ± 0.33 vs. 1.3 ± 0.61 mg/dl; P = 0.008 and 0.96 ± 0.30 vs. 1.27 ± 0.57 mg/dl, P = 0.006, respectively). Biopsy proven acute rejection rate was 11.5% in PKE group and 16.89% in non-PKE patients (P = 0.6). To conclude, paired kidney donation is an excellent way of increasing the donor pool and needs to be promoted to overcome the shortage of suitable kidney in our country.

show abstract

“…[ 7 5 ] Similarly, excellent patient survival rate was seen in other studies by Waigankar et al . (100%)[ 8 ] and Kute et al . (94.64%).…”

Section: Discussionmentioning

confidence: 99%

Paired kidney exchange transplantation: Maximizing the donor pool

P¹,

Sethi²,

Bansal³

et al. 2015

Indian J Nephrol

View full text Add to dashboard Cite

show abstract

“…In India, in the absence of national KPD program, only single-center KPD is practiced. [ 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 ] Table 2 shows the key elements of success of single-center KPD program at the Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences, Ahmedabad, India, a center which has performed 300 KPD transplants in India. [ 2 3 4 5 6 7 8 9 10 ]…”

Section: Kidney-paired Donation In Indiamentioning

confidence: 99%

“…Table 3 shows the outcome of KPD from India. [ 2 3 4 5 6 7 8 9 10 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 ] Waigankar et al . [ 28 ] reported inferior outcome of ABOiKT compared to KPD.…”

Section: Kidney-paired Donation In Indiamentioning

confidence: 99%

Kidney-paired donation to increase living donor kidney transplantation in India: Guidelines of Indian Society of Organ Transplantation – 2017

et al. 2018

View full text Add to dashboard Cite

“…Kidney paired donation contributed to 56 kidney paired donation transplantations in 2013 and 2014 leading to increase living donor kidney transplantation by 15.8% and 18.1% respectively[40-59]. Seventy seven kidney paired donation increased the living donor kidney transplantation rate by 25% in one year in 2015.…”

Section: Outcome Of Single Center Kidney Paired Donation Program In Imentioning

confidence: 99%

“…Between January 2000 and July 2016, 3616 living donor kidney transplantation and 561 deceased donor kidney transplantation were performed at Institute of Kidney Diseases and Research Centre, Dr HL Trivedi Institute of Transplantation Sciences, Ahmedabad, India with 300 of them (8.3%) using kidney paired donation. Kidney paired donation contributed to 56 kidney paired donation transplantations in 2013 and 2014 leading to increase living donor kidney transplantation by 15.8% and 18.1% respectively[ 40 - 59 ]. Seventy seven kidney paired donation increased the living donor kidney transplantation rate by 25% in one year in 2015.…”

Section: Outcome Of Single Center Kidney Paired Donation Program In Imentioning

confidence: 99%

Past, present and future of kidney paired donation transplantation in India

Kute¹,

Patel²,

Shah³

et al. 2017

WJT

View full text Add to dashboard Cite

One third of healthy willing living kidney donors are rejected due to ABO blood group incompatibility and donor specific antibody. This increases pre-transplant dialysis duration leading to increased morbidity and mortality on the kidney transplantation waiting list. Over the last decade kidney paired donation is most rapidly increased source of living kidney donors. In a kidney transplantation program dominated by living donor kidney transplantation, kidney paired donation is a legal and valid alternative strategy to increase living donor kidney transplantation. This is more useful in countries with limited resources where ABO incompatible kidney transplantation or desensitization protocol is not feasible because of costs/infectious complications and deceased donor kidney transplantation is in initial stages. The matching allocation, ABO blood type imbalance, reciprocity, simultaneity, geography were the limitation for the expansion of kidney paired donation. Here we describe different successful ways to increase living donor kidney transplantation through kidney paired donation. Compatible pairs, domino chain, combination of kidney paired donation with desensitization or ABO incompatible transplantation, international kidney paired donation, non-simultaneous, extended, altruistic donor chain and list exchange are different ways to expand the donor pool. In absence of national kidney paired donation program, a dedicated kidney paired donation team will increase access to living donor kidney transplantation in individual centres with team work. Use of social networking sites to expand donor pool, HLA based national kidney paired donation program will increase quality and quantity of kidney paired donation transplantation. Transplant centres should remove the barriers to a broader implementation of multicentre, national kidney paired donation program to further optimize potential of kidney paired donation to increase transplantation of O group and sensitized patients. This review assists in the development of similar programs in other developing countries.

show abstract

Living donor transplant options in end-stage renal disease patients with ABO incompatibility

Cited by 8 publications

References 6 publications

Paired kidney exchange transplantation: Maximizing the donor pool

Paired kidney exchange transplantation: Maximizing the donor pool

Kidney-paired donation to increase living donor kidney transplantation in India: Guidelines of Indian Society of Organ Transplantation – 2017

Past, present and future of kidney paired donation transplantation in India

Contact Info

Product

Resources

About