Living Donor Liver Transplantation in Patients Older Than 60 Years

Yoshizumi, Tomoharu; Shirabe, Ken; Soejima, Yuji; Taketomi, Akinobu; Yamashita, Natsumi; Ikegami, Toru; Uchiyama, Hideaki; Kuwabara, Hiroto; Ninomiya, Mizuki; Maehara, Yoshihiko

doi:10.1097/tp.0b013e3181e81b2d

Cited by 37 publications

(49 citation statements)

References 23 publications

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“…[10][11][12][13] Although there is not a sufficient number of patients in our series, we could not say that the prognosis for patients with comorbid disease and high MELD score was worse.…”

Section: Discussionmentioning

confidence: 65%

Untitled

2015

Exp Clin Transplant

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Objectives: With the increased life span, the need for liver transplant for elderly patients also increased in the world. In this study, we reviewed our experience to determine the outcomes and problems of patients aged > 60 years who had liver transplants. Materials and Methods: Data of recipients aged > 60 years were reviewed retrospectively. We analyzed 16 elderly patients who had liver transplant for chronic liver disease between 2001 and 2014 in our center. Results: In our series, there were 5 women and 11 men between age 60 and 65 years. The mean ChildPugh score was 7.9 ± 1.7 and Model for End-Stage Liver Disease score was 14.1 ± 5.1. Primary liver disease was hepatitis B in 9 patients (34.5%), most of them with hepatocellular carcinoma. The other causes of liver failure were hepatitis C (n = 4), alcoholic cirrhosis (n = 2), and cryptogenic cirrhosis (n = 2); 1 patient had both hepatitis B and hepatitis C virus, and 1 patient had both hepatitis B virus and alcoholic cirrhosis. There were 9 patients who had hepatocellular carcinoma. Mortality was observed in 4 patients. The reasons for mortality were sepsis (n=3) and hepatocellular carcinoma (n=1). Conclusions: Liver transplant can be safely performed and has acceptable long-term outcomes in low-risk elderly recipients. Age alone should not be a contraindication for liver transplant in elderly patients.

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“…[10][11][12][13] Although there is not a sufficient number of patients in our series, we could not say that the prognosis for patients with comorbid disease and high MELD score was worse.…”

Section: Discussionmentioning

confidence: 65%

Untitled

2015

Exp Clin Transplant

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show abstract

“…The recipient age did not affect the outcome of living donor liver transplantations when patients with a low MELD score (<20) received grafts from consanguineous donors [9,10]. Nevertheless, the authors suggest worse long-term results and survival, and an increased risk of postoperative complications in patients with high preoperative MELD scores in those whom marginal organs were transplanted, indicating a significant increase of risk in this type of combination [11].…”

Section: Discussionmentioning

confidence: 79%

Results of Liver Transplantation From Old Donors

Dudek

Kornasiewicz

Remiszewski

et al. 2014

Transplantation Proceedings

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“…Elderly age at LDLT has been associated with worse posttransplantation outcomes, including increased risk of patient death [3,4]. Once some persistent disease such as HCV recurrence develops, long-term treatment in elderly recipients is arduous; therefore this should be considered before an indication for LDLT.…”

Section: Discussionmentioning

confidence: 99%