Living donor liver transplantation for colorectal liver metastasis: a narrative review

Nadalin, Silvio; Genedy, Lara; Königsrainer, Alfred; Settmacher, Utz; Rauchfuß, F.; Testa, Giuliano

doi:10.21037/dmr-20-91

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…LT as a treatment for hepatic metastasis of colorectal cancer started at the University of Vienna in the 1980s. It was discouraged after very unsatisfactory results, even though the significant cause of the high mortality rate was unrelated to the neoplastic disease 14 . More recently, the Oslo Group showed promising results through two studies.…”

Section: Discussionmentioning

confidence: 99%

An Experience on Living Donor Liver Transplantation for Colorectal Liver Metastasis in South America: A New Era in Transplant Oncology

Fernandes,

Souza,

Braga

et al. 2023

ABCD, arq. bras. cir. dig.

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BACKGROUND: Complete surgical resection is the treatment of choice for patients with liver metastases, but in some patients, it is not possible to obtain a complete R0 resection. Moreover, the recurrence rate is up to 75% after three years. After the experience of the Oslo group with cadaveric liver transplant, some centers are starting their experience with liver transplant for colorectal liver metastasis. AIMS: To present our initial experience with living donor liver transplant for colorectal liver metastasis. METHODS: From 2019 to 2022, four liver transplants were performed in patients with colorectal liver metastases according to the Oslo criteria. RESULTS: Four patients underwent living donor liver transplants, male/female ratio was 3:1, mean age 52.5 (42–68 years). All patients were included in Oslo criteria for liver transplant. Two patients had already been submitted to liver resection. The decision for liver transplant occurred after discussion with a multidisciplinary team. Three patients recurred after the procedure and the patient number 3 died after chemotherapy. CONCLUSIONS: Living donor liver transplant is a viable treatment option for colorectal liver metastasis in Brazil, due to a shortage of donors.

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Section: Discussionmentioning

confidence: 99%

An Experience on Living Donor Liver Transplantation for Colorectal Liver Metastasis in South America: A New Era in Transplant Oncology

Fernandes,

Souza,

Braga

et al. 2023

ABCD, arq. bras. cir. dig.

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“…The main drawbacks of RAPID livers are the scarcity of deceased donor grafts that can be split, the increased risk of biliary complications, and the high complexity of the procedure. There is also a possible risk of tumor dissemination and increased growth of the malignant disease secondary to immunosuppressive therapy during the 2-4 weeks of the liver regeneration phase [79,80]. Also, most recipients reported so far had CRLM, were not cirrhotic, and had good liver function prior to transplantation.…”

Section: Auxiliary Partial Orthotopic Liver Transplantation and Rapid...mentioning

confidence: 99%

Liver transplantation for intrahepatic cholangiocarcinoma: who, when and how

Achurra,

Fernandes,

O’Kane

et al. 2024

Current Opinion in Organ Transplantation

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Purpose of review Using transplant oncology principles, selected patients with intrahepatic cholangiocarcinoma (iCCA) may achieve long-term survival after liver transplantation. Strategies for identifying and managing these patients are discussed in this review. Recent findings Unlike initial reports, several modern series have reported positive outcomes after liver transplantation for iCCA. The main challenges are in identifying the appropriate candidates and graft scarcity. Tumor burden and response to neoadjuvant therapies have been successfully used to identify favorable biology in unresectable cases. New molecular biomarkers will probably predict this response in the future. Also, new technologies and better strategies have been used to increase graft availability for these patients without affecting the liver waitlist. Summary Liver transplantation for the management of patients with unresectable iCCA is currently a reality under strict research protocols. Who is a candidate for transplantation, when to use neoadjuvant and locoregional therapies, and how to increase graft availability are the main topics of this review.

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Liver Transplantation

Line

Adam

2022

Colorectal Liver Metastasis

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Living donor liver transplantation for colorectal liver metastasis: a narrative review

Cited by 5 publications

References 55 publications

An Experience on Living Donor Liver Transplantation for Colorectal Liver Metastasis in South America: A New Era in Transplant Oncology

An Experience on Living Donor Liver Transplantation for Colorectal Liver Metastasis in South America: A New Era in Transplant Oncology

Liver transplantation for intrahepatic cholangiocarcinoma: who, when and how

Liver Transplantation

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