Living Donor Liver Transplant Versus Cadaveric Liver Transplant Survival in Relation to Model for End-Stage Liver Disease Score

Sebayel, Mohammed Al; Abaalkhail, Faisal; Hashim, Almoutaz; Bahili, Hamad Al; Alabbad, Saleh; Shoukdy, M.; Elsiesy, Hussien

doi:10.1016/j.transproceed.2015.01.024

Cited by 13 publications

(9 citation statements)

References 14 publications

(9 reference statements)

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“…Patients with MELD scores above 25 had survival rates similar to those of patients with MELD scores below 25, although their intensive care unit (ICU) and hospital stays were longer. (14) We have also shown that LDLT survival was significantly better than DDLT survival among 642 adults (352 LDLT, 290 DDLT; Fig. 2).…”

Section: Indications and Recipient Selectionmentioning

confidence: 64%

Liver transplantation in the Kingdom of Saudi Arabia

Sebayel¹,

Abaalkhail²,

Abbad³

et al. 2017

Liver Transpl

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The first liver transplantation (LT) in Saudi Arabia was performed in 1991; however, it was not until 1994 that the first structured LT program was launched. Until 1997, all LTs in the Kingdom of Saudi Arabia (KSA) were deceased donor liver transplantations. Programs performing LTs needed the authorization of the Saudi Center for Organ Transplantation (SCOT), which provides the essential support for organ procurement and allocation as well as regulatory support for organ transplantation in the country. Currently, there are 4 LT centers in the KSA. Three centers are in Riyadh, the capital city of KSA, and 1 is in the city of Dammam in the Eastern province. Pediatric living donor liver transplantation (LDLT) began in 1997, while the adult LDLT program started 4 years later in 2001. Currently, more than 2000 LTs have been performed by the 4 centers in the KSA. Over 50% of those were performed at King Faisal Specialist Hospital and Research Center in Riyadh. The outcomes of these transplants have been comparable with the international standards. The aim of this review is to provide an overview of LT in KSA. Liver Transplantation 23 1312-1317 2017 AASLD.

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Section: Indications and Recipient Selectionmentioning

confidence: 64%

Liver transplantation in the Kingdom of Saudi Arabia

Sebayel¹,

Abaalkhail²,

Abbad³

et al. 2017

Liver Transpl

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“…Ten studies [ 18 , 25 – 27 , 32 , 36 , 38 , 40 – 42 ] reported perioperative mortality, and all of them suggested no significant difference between LDLT and DDLT. No significant heterogeneity was observed ( P = 0.10, I 2 = 39%).…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies [ 11 , 15 , 22 , 24 , 27 , 31 , 32 , 42 ] reported the retransplantation rate. While six of them [ 15 , 22 , 24 , 27 , 31 , 32 ] indicated no significant difference between LDLT and DDLT, 2 studies [ 11 , 42 ] showed a significantly higher retransplantation rate in LDLT. No significant heterogeneity was observed ( P = 0.20, I 2 = 29%).…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies [ 4 , 11 , 13 – 16 , 21 , 24 – 28 , 34 , 35 , 39 , 41 , 44 , 47 ] reported 1-year OS. Four of them [ 13 , 14 , 16 , 28 ] suggested a significantly higher 1-year OS in LDLT, and the rest [ 4 , 11 , 15 , 21 , 24 – 27 , 34 , 35 , 39 , 41 , 44 , 47 ] showed no significant difference between LDLT and DDLT. A random-effect model revealed a significantly higher 1-year OS in LDLT (OR = 1.32, 95%CI = 1.01 to 1.72, P = 0.04; Figure 15 ).…”

Section: Resultsmentioning

confidence: 99%

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Increased Surgical Complications but Improved Overall Survival with Adult Living Donor Compared to Deceased Donor Liver Transplantation: A Systematic Review and Meta-Analysis

Tang

Qiu

Cai

et al. 2020

BioMed Research International

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Background. Living donor liver transplantation (LDLT) provides an alternative to deceased donor liver transplantation (DDLT) for patients with end-stage liver disease in the circumstance of scarcity of deceased grafts. However, the outcomes of LDLT remain controversial. Method. A systematic review and meta-analysis were performed to compare the outcomes of LDLT with DDLT. Twelve outcomes were assessed. Results. Thirty-nine studies involving 38563 patients were included. LDLT was comparable in red blood cell transfusion, perioperative mortality, length of hospital stay, retransplantation rate, hepatitis C virus recurrence rate, and hepatocellular carcinoma recurrence rate with DDLT. Cold ischemia time was shorter and duration of recipient operation was longer in LDLT. Postoperative intra-abdominal bleeding rate occurred less frequently in LDLT recipients (odds ratio OR=0.64, 95%confidence interval CI=0.46−0.88, P=0.006), but this did not decrease the perioperative mortality. LDLT was associated with significantly higher biliary (OR=2.23, 95%CI=1.59−3.13, P<0.00001) and vascular (OR=2.00, 95%CI=1.31−3.07, P=0.001) complication rates and better overall survival (OS) (1 year: OR=1.32, 95%CI=1.01−1.72, P=0.04; 3 years: OR=1.39, 95%CI=1.14−1.69, P=0.0010; and 5 years: OR=1.33, 95%CI=1.04−1.70, P=0.02). According to subgroup analysis, biliary complication rate and OS improved dramatically as experience increased, while vascular complication rate could not be improved because it was mainly caused by the difference of the donor type itself. Conclusions. LDLT remains a valuable option for patients in need of liver transplantation for it provides an excellent alternative to DDLT without compromising recipient outcomes. Further refinement in biliary and vascular reconstruction techniques and the accumulation of liver transplantation centers’ experience are the key factors in expanding the application of LDLT.

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“…[1][2][3] In addition, various investigations in the literature validated the efficacy of the modality for different age groups, although many of them reported the incidence of different related complications. 4,5 In Saudi Arabia, not many studies reported the safety and efficacy of liver transplantation for pediatric patients. However, reports show that Saudi Arabia is one of the earliest countries in the Middle East to perform this procedure.…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of pediatric liver transplantation in Saudi Arabia

Mehder¹,

Saati

Alhamdani

et al. 2022

Int J Community Med Public Health

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Evidence shows that liver transplantation is a good management choice for pediatric patients with severe hepatic disorders. In addition, the approach can be used for managing different hepatic disorders, including metabolic and familial ones. Therefore, liver transplantation is indicated and should be urgently conducted to intervene against further deterioration in the health status of the affected patients and enhance their prognosis. Various investigations in the literature validated the efficacy of the modality for different age groups, although many of them reported the incidence of different related complications. In Saudi Arabia, not many studies reported the safety and efficacy of liver transplantation for pediatric patients. The present literature review provided insight regarding the safety and efficacy of the procedure for this population group. We can conclude that liver transplantation in pediatric settings is a safe and productive approach that can be successfully conducted with a favorable prognosis. Moreover, it has been shown that living-related liver transplantation is more favorable than cadaveric-related liver transplantation in these settings, especially when there is a graft shortage, as reported in Saudi Arabia. Despite the favorable outcomes, further reports are still needed for validating the current evidence.

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Living Donor Liver Transplant Versus Cadaveric Liver Transplant Survival in Relation to Model for End-Stage Liver Disease Score

Cited by 13 publications

References 14 publications

Liver transplantation in the Kingdom of Saudi Arabia

Liver transplantation in the Kingdom of Saudi Arabia

Increased Surgical Complications but Improved Overall Survival with Adult Living Donor Compared to Deceased Donor Liver Transplantation: A Systematic Review and Meta-Analysis

Safety and efficacy of pediatric liver transplantation in Saudi Arabia

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