Livestock genomics comes of age.

Georges, Michel; Andersson, Leif

doi:10.1101/gr.6.10.907

Cited by 72 publications

(51 citation statements)

References 79 publications

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“…Except for human, mouse, and rat, the only other gene maps that have exhibited exponential growth are those of the domestic animals. The economic implications of the gene maps in the latter species to the farm animal industry have been the driving force behind this progress (e.g., see Georges and Andersson 1996). One of the significant outcomes of the development of gene maps in different species is that they have enabled us to detect those segments of genomes which, beginning from a common ancestor, have remained conserved over several million years of evolution (Wienberg and Stanyon 1995;Comparative Genome Organization 1996;O'Brien et al 1997b;.…”

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confidence: 99%

“…The transfer of mapping information from map rich species to map poor species will be viable only if sufficient and accurate data is available on the comparative organization of any of the two genomes. The significance of detailed comparative information at different levels of resolution (ranging from gross chromosomal to map location of different genes) has been emphasized in the recent past for searching candidate loci governing traits of biological and economic importance, both in humans and farm animals (e.g., Georges et al 1993;Montgomery et al 1993;Andersson et al 1994;Cockett et al 1994;Charlier et al 1995;Georges and Andersson 1996;Johansson-Moller et al 1996;Grobet et al 1997;Kambadur et al 1997).…”

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confidence: 99%

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Emerging Patterns of Comparative Genome Organization in Some Mammalian Species as Revealed by Zoo-FISH

Chowdhary¹,

Raudsepp²,

Frönicke³

et al. 1998

Genome Res.

211

143

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Although gene maps for a variety of evolutionarily diverged mammalian species have expanded rapidly during the past few years, until recently it has been difficult to precisely define chromosomal segments that are homologous between species. A solution to this problem has come from the development of Zoo-FISH, also known as cross-species chromosome painting. The use of Zoo-FISH to identify regions of chromosomal homology has allowed the transfer of information from map-rich species such as human and mouse to a wide variety of other species. From a Zoo-FISH analysis spanning four mammalian orders (Primates, Artiodactyla, Carnivora, and Perissodactyla), and involving eight species (human, pig, cattle, Indian muntjac, cat, American mink, harbor seal, and horse), three distinct classes of synteny conservation have been designated: (1) conservation of whole chromosome synteny, (2) conservation of large chromosomal blocks, and (3) conservation of neighboring segment combinations. This analysis has also made it possible to identify a set of chromosome segments (based on human chromosome equivalents) that probably made up the karyotype of the common ancestor of the four orders. This approach provides a basis for developing a picture of the ancestral mammalian karyotype, but a full understanding will depend on studies encompassing more diverse combinations of mammalian orders.

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confidence: 99%

mentioning

confidence: 99%

Emerging Patterns of Comparative Genome Organization in Some Mammalian Species as Revealed by Zoo-FISH

Chowdhary¹,

Raudsepp²,

Frönicke³

et al. 1998

Genome Res.

211

143

View full text Add to dashboard Cite

show abstract

“…It should ultimately lead to more efficient breeding schemes (marker-assisted selection or MAS) and improve the accuracy and intensity of selection programs [18,22]. In this perspective, genetic maps constructed in various livestock species [3,12,26,29,46] are sufficient to detect regions containing genes and QTL.…”

Section: Introductionmentioning

confidence: 99%

A first generation bovine BAC-based physical map

et al. 2004

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-A first generation clone-based physical map for the bovine genome was constructed combining, fluorescent double digestion fingerprinting and sequence tagged site (STS) marker screening. The BAC clones were selected from an Inra BAC library (105 984 clones) and a part of the CHORI-240 BAC library (26 500 clones). The contigs were anchored using the screening information for a total of 1303 markers (451 microsatellites, 471 genes, 127 EST, and 254 BAC ends). The final map, which consists of 6615 contigs assembled from 100 923 clones, will be a valuable tool for genomic research in ruminants, including targeted marker production, positional cloning or targeted sequencing of regions of specific interest.cattle / physical map / BAC

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“…In cattle, numerous reports have identified genomic regions corresponding to economically important traits [3,5,7] based on low to medium density marker maps. The density of these maps, however, is not sufficient to identify DNA variations responsible for genetic variation.…”

Section: Introductionmentioning

confidence: 99%

Construction and characterization of a bovine BAC library with four genome-equivalent coverage

et al. 2001

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-A bovine artificial chromosome (BAC) library of 105 984 clones has been constructed in the vector pBeloBAC11 and organized in 3-dimension pools and high density membranes for screening by PCR and hybridization. The average insert size, determined after analysis of 388 clones, was estimated at 120 kb corresponding to a four genome coverage. Given the fact that a male was used to construct the library, the probability of finding any given autosomal and X or Y locus is respectively 0.98 and 0.86. The library was screened for 164 microsatellite markers and an average of 3.9 superpools was positive for each PCR system. None of the 50 or so BAC clones analysed by FISH was chimeric. This BAC library increases the international genome coverage for cattle to around 28 genome equivalents and extends the coverage of the ruminant genomes available at the Inra resource center to 15 genome equivalents. bovine / BAC library / mapping

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Livestock genomics comes of age.

Cited by 72 publications

References 79 publications

Emerging Patterns of Comparative Genome Organization in Some Mammalian Species as Revealed by Zoo-FISH

Emerging Patterns of Comparative Genome Organization in Some Mammalian Species as Revealed by Zoo-FISH

A first generation bovine BAC-based physical map

Construction and characterization of a bovine BAC library with four genome-equivalent coverage

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