Livestock-associated Methicillin-resistant Staphylococcus aureus as a New Impendence for Public Health

Vaganova, Anastasia N.; Борисенко, С. В.; Sokurova, Alla Mikhaylovna; Вербов, В. Н.

doi:10.22625/2072-6732-2019-11-4-122-133

Cited by 4 publications

(5 citation statements)

References 58 publications

(64 reference statements)

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“…В составе группы метициллинрезистентных стафилококков (MRSA) выделяют: внутрибольничные варианты MRSA, внебольничные MRSA, MRSA, ассоциированные с сельскохозяйственными животными, распространённые среди сельскохозяйственных животных (livestock-associated MRSA, LA-MRSA) [10,9] Недавние исследования показали, что эти 2 подвида не отличаются по генотипу или клиническим признакам, которые они вызывают,следовательно, оба должны считаться важными патогенами. коагулазоположительные и коагулазоотрицательные S schleiferi связаны с пиодермией (особенно рецидивирующей пиодермией) и отитом у собак с аллергическим дерматитом, хотя также сообщалось об инфекциях других участков тела у собак проявления аллергической реакции [4,5,8].…”

Section: результаты и обсуждениеunclassified

“…Продукция этого низкоаффинного пенициллинсвязывающего белка обеспечивает высокую устойчивость практически ко всем производным бета-лактама, включая такие, как: карбапенемы, цефалоспорины, пеницилли-ны, потенцированные пенициллины (например, амоксициллин и клавулановая кислота). Для серологического метода диагностики применяют тест латекс-агглютинации для идентификации MRSA и MSSA (ПСБ2а/ПСБ2с-пеницилинсвязывающий белок) [1,6,7,10].…”

Section: результаты и обсуждениеunclassified

“…Чтобы профилактировать развитие резистентности разработаны различные руководства, целью которых является предупреждение бесконтрольного применения антибиотиков. Следует серьезно подойти к вопросу о антибиотикорезистентности, что имеет быструю тенденцию к ее появлению у домашних животных [7,10,11].…”

Section: результаты и обсуждениеunclassified

“…Устойчивость стафилококков к пенициллину составляет по данным исследований около 80%. Такая высокая устойчивость вызвана выработкой специфического фермента -пенициллазы, синтез которого опосредуется бета-лактамными антибиотиками [9,10,2,5,4].…”

Section: Introductionunclassified

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Laboratory methods for monitoring resistance to methycillin of Staphylococcus of zoonotic origin

Makavchik

Borisova

2023

jour

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The development of antibiotic resistance in microorganisms is considered a modern phenomenon, which is usually caused by empirical antibiotic therapy. One of the representatives with high antibiotic resistance is staphylococcus aureus.Staphylococcus aureus is a pathogen resistant to broad-spectrum antibiotics and is responsible for most nosocomial infections. This microorganism synthesizes penicillinase, an enzyme that breaks down penicillin molecules. To effectively combat Staphylococcus aureus, a modified penicillin, methicillin, was previously used, the molecule of which was not destroyed by this enzyme. However, methicillin-resistant strains of this pathogen are also known today.As part of the group of methicillin-resistant staphylococci (MRSA), there are three subgroups: nosocomial variants of MRSA, community-acquired MRSA, MRSA associated with farm animals, common among farm animals (livestockassociated MRSA, LA-MRSA). MRSA are characterized by multidrug resistance.It was previously believed that Staphylococcus intermedius is the most dangerous staphylococcus for pets. However, over the past few years it has been found that the most common is Staphylococcus pseudintermedius, which is gaining increasing relevance. Staphylococcus pseudintermedius (MRSP) is a bacterium commonly found on the skin, mouth, nasal mucosa, and gastrointestinal tract in approximately 50% of pets. Unlike MRSA, MRSP is much more common in dogs and cats. One of the main methods of laboratory control over their spread is a monitoring study of the epizootic and epidemiological situation among animals and the population.The home environment plays a major role in the transmission of MRSA and MRSP, therefore, by taking careful measures to prevent the spread of infection, the likelihood of infection in both companion animals and humans can be reduced.The determination of sensitivity and resistance by phenotypic methods is carried out using: disk diffusion method, broth microdilution method, agar dilution method, E-test method.Laboratory methods for monitoring the mechanisms of resistance of staphylococci to methicillin include phenotypic methods using disks with oxacillin, or cefoxitin.Genotypic methods using polymerase chain reaction allow detecting the mecA, mecC gene.For a serological diagnostic method, a latex agglutination test is used to identify MRSA and MSSA (PSB2a / PSB2 spicelin-binding protein).Treatment of animals requires special attention because infections caused by multi-resistant staphylococci are more severe, chronic or latent, which increases the duration of treatment.

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Section: результаты и обсуждениеunclassified

Section: Introductionunclassified

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Laboratory methods for monitoring resistance to methycillin of Staphylococcus of zoonotic origin

Makavchik

Borisova

2023

jour

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“…Інші вчені наголошують, що незважаючи на істотне вивчення питань епізоотології та діагностики збудника S. aureus, увагу до себе привертає відносно високий рівень реєстрації захворювань серед тварин і людей, тривале безсимптомне бактеріоносійство та виявлення нових факторів патогенності золотистого стафілококазростання стійкості до антибактеріальних препаратів, формування бактерійних біоплівок та ін. [7].…”

Section: рис 1 середні показники виділення ізолятів S Aureus із патологічного і біологічного матеріалу від тварин і птиці на території укunclassified

Distribution of staphylococcosis among animals and birds in 2015-2020

Garkavenko¹,

Gorbatyuk²,

Kozytska³

et al. 2021

Veterinary biotechnology

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Analysis of bacterioses in the Kharkiv region for the period 2019-2022

Ushkalov

2023

Nauk. vìsn. vet. med.

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An important link in maintaining epizootic well-being is a timely diagnosis of an infectious animal disease. In today’s conditions and increased requirements for biosafety, the importance and responsibility of conducting laboratory research is growing. Only a laboratory-confirmed diagnosis is definitive. For the most part, the classic bacteriological method is the basis for an expert opinion and as a result of a laboratory study aimed at identifying the causative agents of bacterial diseases. The relevance of a zoonotic disease is determined by epizootological, epidemiological, ecological, socio-economic values and biosafety for humans and animals. In the article, a thorough analysis and representative results of laboratory studies of biomaterial from different species of animals and data on the dominant and sporadically appearing causative agents of animal bacteriosis in the territory of the Kharkiv region are carried out. The structure of the main causative agents and objects of excretion is determined. Thus, according to the re sults of bacteriological monitoring, it was established that causative agents of colibacteriosis (41%), staphylococcus (30%), streptococcus (17%), salmonellosis (5%), and pasteurellosis (2%) are circulating in the Kharkiv region. The share of causative agents of dysentery, aeromonosis and American bee rot is 1.48% each. The results of the research prove the necessity of continuing bacteriological monitoring for the detection of bacterial pathogens in the territory of the Kharkiv region and the entire territory of Ukraine in order to maintain public and timely prevention of zoonotic diseases. Key words: bacteriosis, colibacteriosis, salmonellosis, staphylococcus, streptococcus, research, epizootic index, bacteriological monitoring, bacterial diseases, causative agent.

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Livestock-associated Methicillin-resistant Staphylococcus aureus as a New Impendence for Public Health

Cited by 4 publications

References 58 publications

Laboratory methods for monitoring resistance to methycillin of Staphylococcus of zoonotic origin

Laboratory methods for monitoring resistance to methycillin of Staphylococcus of zoonotic origin

Distribution of staphylococcosis among animals and birds in 2015-2020

Analysis of bacterioses in the Kharkiv region for the period 2019-2022

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