Liver venous deprivation compared to portal vein embolization to induce hypertrophy of the future liver remnant before major hepatectomy: A single center experience

Kobayashi, Kosuke; Yamaguchi, Takeshi; Denys, Alban; Perron, Linda; Halkic, Nermin; Demartines, Nicolas; Melloul, Emmanuel

doi:10.1016/j.surg.2019.12.006

Cited by 72 publications

(95 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consequently, in the case of benign pathologies, less aggressive approaches should be preferred for consenting the FLR hypertrophy, like the liver venous deprivation (LVD) (68). In LVD, the simultaneous embolization of hepatic and portal vein is done, inducing a more significant and faster FLR hypertrophy than after portal vein embolization (PVE) alone (69). This alternative FLR increasing technique should represent a future promising and less invasive procedure respect to the, evidently more aggressive, ALPPS approach, mainly if a non-tumoral pathology is managed.…”

Section: Discussionmentioning

confidence: 99%

Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy: a systematic review

Lai¹,

Mennini²,

Laureiro³

et al. 2021

Hepatobiliary Surg Nutr

View full text Add to dashboard Cite

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) represents an innovative surgical technique used for the treatment of large hepatic lesions at high risk for post-resection liver failure due to a small future liver remnant. The most significant amount of literature concerns the use of ALPPS for the treatment of hepatocellular carcinoma (HCC), cholangiocarcinoma (CCC), and colorectal liver metastases (CRLM). On the opposite, few is known about the role of ALPPS for the treatment of uncommon liver pathologies. The objective of the present study was to evaluate the current literature on this topic. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible articles published up to February 2020 were included using the MEDLINE, Scopus, and Cochrane databases. Among the 486 articles screened, 45 papers met the inclusion criteria, with 136 described cases of ALPPS for rare indications. These 136 cases were reported in 18 different countries. Only in two countries, namely Germany and Brazil, more than ten cases were observed. As for the ALPPS indications, we reported 41 (30.1%) cases of neuroendocrine tumor (NET) metastases, followed by 27 (19.9%) cases of gallbladder cancer (GBC), nine (6.6%) pediatric cases, six (4.4%) gastrointestinal stromal tumors, six (4.4%) adult cases of benign primary liver disease, four (2.9%) adult cases of malignant primary liver disease, and 43 (31.6%) adult cases of malignant secondary liver disease.According to the International ALPPS Registry data, less than 10% of the ALPPS procedures have been performed for the treatment of uncommon liver pathologies. NET and GBC are the unique pathologies with acceptable numerosity. ALPPS for NET appears to be a safe procedure, with satisfactory long-term results. On the opposite, the results observed for the treatment of GBC are poor. However, these data should be considered with caution. The rationale for treating benign pathologies with ALPPS appears to be weak.No definitive response should be given for all the other pathologies. Multicenter studies are needed with the intent to clarify the potentially beneficial effect of ALPPS for their treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy: a systematic review

Lai¹,

Mennini²,

Laureiro³

et al. 2021

Hepatobiliary Surg Nutr

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

“…Four monocentric studies comparing LVD to PVE were published in 2020 (1)(2)(3)(4). Despite technical variations, these reports are aligned towards greater FLR regeneration after LVD, both in terms of volume (1,2,4) and function (3). In our series (29 LVD vs. 22 PVE), we reported a 54% increase in FLR function (99mTc-mebrofenin scintigraphy) as early as 7 days after LVD, which is unprecedented for a liver preparation technique.…”

mentioning

confidence: 99%

Liver venous deprivation: a bright future for liver metastases—but what about hepatocellular carcinoma?

Guiu¹,

Herrero²,

Panaro³

2021

Hepatobiliary Surg Nutr

View full text Add to dashboard Cite

“…A novel procedure to increase FLR is hepatic vein embolization in combination with PVE [39], which shows promising results for FLR hypertrophy compared to ALPPS [39][40][41]. Even for extended resection, the embolization of the right and middle hepatic vein is described [42].…”

Section: Discussionmentioning

confidence: 99%

Complex Liver Resections for Intrahepatic Cholangiocarcinoma

Reese

Pagel

Bause

et al. 2021

JCM

View full text Add to dashboard Cite

The only curative treatment option for intrahepatic cholangiocarcinoma (iCCA) is liver resection. Due to central tumor localization and vascular invasion, complex liver resections play an important role in curative treatment. However, the long-term outcomes after complex liver resection are not known. Methods: A retrospective cohort study was conducted for all patients undergoing liver surgery for iCCA. Complex liver resections included ante situm resections, associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and major liver resection with vascular reconstructions. Results: Forty-nine patients (34%) received complex liver resection, 66 patients (46%) received conventional liver resection and 28 patients (20%) were not resectable during exploration. Preoperative characteristics were not different between the groups, except for Union for International Cancer Control (UICC) stages. The postoperative course for complex liver resections was associated with more complications and perioperative mortality. However, long-term survival was not different between complex and conventional resections. Independent risk factors for survival were R0 resections and UICC stage. Four patients underwent ante situm resection without any mortality. Conclusions: Complex liver resections are justified in selected patients and survival is comparable with conventional liver resections. Survival in iCCA is affected by UICC stage or resections margins and not by the complexity of the case.

show abstract

Liver venous deprivation compared to portal vein embolization to induce hypertrophy of the future liver remnant before major hepatectomy: A single center experience

Cited by 72 publications

References 27 publications

Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy: a systematic review

Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy: a systematic review

Liver venous deprivation: a bright future for liver metastases—but what about hepatocellular carcinoma?

Complex Liver Resections for Intrahepatic Cholangiocarcinoma

Contact Info

Product

Resources

About