Liver Tumors: Monitoring Embolization in Rabbits with VX2 Tumors—Transcatheter Intraarterial First-Pass Perfusion MR Imaging

Abstract

TRIP MR imaging can depict serial reductions in liver tumor perfusion during TAE. TRIP MR imaging offers the potential to target functional embolic end points during TAE.

CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours

“…Percentage change in tumour size (△TS) [12] on all rabbits between baseline and 14-day follow-up was calculated as following: ΔTS = (LD 14days − LD baseline )/LD baseline * 100 %, where LD is the longest dimension of the tumour. At each time point, an iodine concentration (IC) of the tumour was measured on the iodine-based MD image by using an operator-defined region of interest (ROI) (mean value 206 mm 2 , range 102-409 mm 2 ) around the entire tumour [13,28] (Fig. 1).…”

Transcatheter Intraarterial Perfusion: MR Monitoring of Chemoembolization for Hepatocellular Carcinoma—Feasibility of Initial Clinical Translation

“…Transcatheter intraarterial perfusion (TRIP) MR imaging involves direct catheter-based intraarterial injection of contrast material (7). This technique was used initially to measure objective functional changes in first-pass perfusion during liver tumor embolization in preclinical rabbit studies (7), but it awaits clinical application.…”

Perfusion Reduction at Transcatheter Intraarterial Perfusion MR Imaging: A Promising Intraprocedural Biomarker to Predict Transplant-Free Survival during Chemoembolization of Hepatocellular Carcinoma

“…Intraprocedural imaging biomarkers predictive of survival during transarterial local-regional therapies could potentially further enhance the benefits of these interventions in patients with unresectable HCC, as intraprocedural prognostic factors could be used to guide the selection of optimal therapeutic end points at the time of treatment. Intraprocedural MR imaging allows assessment of tumor functional status during transarterial local-regional therapies (19). Transcatheter intraarterial perfusion (TRIP) MR imaging, which employs catheter-directed intraarterial injections of contrast material, can be applied to monitor tumor perfusion changes during chemoembolization (20)(21)(22)(23) and to model the biodistribution of chemoembolic material before delivery (24,25).…”

“…Although thermal ablation, surgical resection, and orthotopic liver transplantation represent curative treatments for HCC, only 15% of patients with HCC are candidates for definitive therapy because of advanced multifocal intrahepatic disease, poor hepatic reserve, extrahepatic tumor spread, and/or scarcity of donor organs (5,6 Other common parameters were as follows: 15° flip angle, 192 3 128 matrix, 380-450-mm field of view, and generalized autocalibrating partially parallel factor of 2. These imaging parameters were chosen to provide a relatively linear relationship between signal intensity and tissue contrast material concentration and rapid acquisition of T1-weighted images (19). Five seconds after each dynamic TRIP MR imaging examination, a gadopentetate dimeglumine solution (Magnevist; Berlex, Montville, NJ) was injected by hand through the catheter inside the hepatic artery.…”