Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern

Long-term streptozotocin diabetes impairs arachidonic and docosahexaenoic acid metabolism and ∆5 desaturation indices in aged rats

“…A significant diabetes × age interaction was also noticeable for Δ9 desaturation in the liver and muscle, and increasing age worsened the alterations observed in 6 month diabetic rats. Palmitic acid (C16:0) significantly decreased in virtually all examined tissues, which is similar to the results of studies conducted on a short-term IDDM model (Comte et al, 2004;Ghebremeskel et al, 2002). On the basis of C16:0 values, we calculated the "de novo lipogenesis index" to represent the proportion of endogenously synthesized fatty acids.…”

“…The expression of transcription factors such as PPARs is also changed Son et al, 2007) and in some experiments insulin restores values to normal . The most consistent changes in the fatty acid composition of different tissues in IDDM experimental rats include: a decrease in palmitic acid (Chanussot et al, 1997;Comte et al, 2004;Ghebremeskel et al, 2002;Malaisse et al, 2006) and a decrease in monounsaturated fatty acids (MUFA) (Comte et al, 2004;Montanaro et al, 2005). Other important changes are not consistent and include a decrease in 20:4n6 and/or increase in its precursors (18:2n6 and 20:3n6), and an unusual increase in 22:6n3 (Brenner, 2003).…”

Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women

“…Poisson (1993) have postulated that, 'other factors independent of desaturation and elongation may play a pivotal role in the altered lipid biochemistry in chemically induced and genetically diabetic rats'. Similarly, Ghebremeskel et al (2002) have suggested that the contrasting levels of AA and DHA between neutral, and membrane phospholipids of diabetic rats could be due to alterations in the regulatory mechanism responsible for the distribution of these fatty acids between the lipid pools.…”

Fatty Acid Supply in Pregnant Women with Type 1 Diabetes Mellitus

“…Nevertheless, we found only two human studies investigating the fatty acid supply during pregnancy in women with T1DM and four studies investigating fatty acid supply in cord blood lipids of newborns born from mothers with T1DM (Table 4). Ghebremeskel et al (Ghebremeskel et al, 2002) induced diabetes with streptozotocin in pregnant rats and investigated the liver fatty acid composition. They found significantly higher essential fatty acid values (ALA and LA) as well as n-3 and n-6 LCPUFA values (AA, EPA, DPA and DHA) in the TG and NEFA fractions.…”