Liver trauma grading and biochemistry tests

Arslan, Gözde; Gemici, Aysegul Akdogan; Yırgın, İnci Kızıldağ; Gulsen, Esma; İnci, Ercan

doi:10.1007/s10140-013-1140-x

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Similar to IVC diameter, systolic blood pressure is presumed to reflect circulatory blood volume, suggesting that high systolic blood pressure may impede the reduction of hemoglobin levels post-trauma [8]. Regarding LDH, tissue damage leads to the release of LDH in direct proportion to the severity of the damage [12,13]. Similar to FDP, severe trauma can induce substantial hemorrhaging, resulting in thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

The Factors Associated With Decreasing Hemoglobin Levels and Platelet Counts After Trauma

Yanagawa,

Nagasawa,

Ota

et al. 2024

Cureus

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In this study, we investigated the factors related to anemia and platelet reduction in patients with moderate to severe trauma to gain a deeper understanding of these phenomena. MethodsOur study spanned the period from April 2021 to September 2023, and it involved a retrospective review of the hospital medical charts of all emergency outpatients of all ages who were transported by a physicianstaffed helicopter and treated at our hospital and were diagnosed with an Injury Severity Score (ISS) of >8 by CT on arrival. The following data were analyzed: sex; age; mechanism of injury; vital signs upon arrival at the hospital; ISS; hemoglobin level and platelet count on arrival and day two; fibrin degradation product (FDP) level, lactate dehydrogenase (LDH) level, and diameter of the inferior vena cava (IVC) on arrival; and infusion volume on day one. We then statistically calculated the independent risk factors for differences between hemoglobin levels and platelet counts on arrival and those on day two. ResultsThe study included a total of 209 subjects, with an average age of 58 years and a male predominance. Multivariate analysis showed that the FDP level, IVC diameter, and age were significantly associated with changes in hemoglobin levels on arrival and day two, whereas the IVC diameter, LDH, age, systolic blood pressure, and sex were significantly associated with changes in the platelet count on arrival and day two. ConclusionsA noteworthy correlation was found between certain factors and changes in hemoglobin levels and platelet counts between the initial assessment and the second day in our cohort. We recommend further prospective research to determine whether our findings hold true for a larger population of trauma patients.

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Section: Discussionmentioning

confidence: 99%

The Factors Associated With Decreasing Hemoglobin Levels and Platelet Counts After Trauma

Yanagawa,

Nagasawa,

Ota

et al. 2024

Cureus

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“…2c) but significant difference was observed only in the first hour. Blood levels of liver enzymes are known to correlate with the degree of liver damage in various clinical conditions, including trauma 34,35 . In the current study, levels of ALT were higher in the control group throughout the experiment with significant difference from the 4th hour to the end of the monitoring period, suggesting a positive effect of VLGL in reducing the extent of liver injury.…”

Section: Discussionmentioning

confidence: 99%

A feasibility study using sodium alginate injection for penetrating abdominal trauma in a swine model

Barsky

Ya’acov

Avraham

et al. 2022

Sci Rep

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Penetrating abdominal injury is a major cause of death in trauma. Sodium alginate hydrogel, a hemostatic agent, offers a platform for targeting both mechanical and biological injuries. The current study assessed the effect of Very Low Viscosity (high) G (VLVG) alginate following abdominal trauma in a swine model of penetrating abdominal injury. Seven anesthetized pigs were instrumented with invasive monitoring catheters and abdominal trauma was introduced by laparoscopic hepatectomy. Ten minutes after the induction of hypovolemic shock, three animals were intra-abdominally administered with VLVG alginate (study group) and four animals with saline (control group). During 8 h of continuous monitoring, various hemodynamic and biochemical variables were measured and liver biopsies for histological evaluation were taken. Hemodynamically, VLVG alginate-treated animals were more stable than controls, as reflected by their lower heart rate and higher blood pressure (p < 0.05 for both). They also had lower levels of liver enzymes and lactate, and less histopathological damage. We show that VLVG alginate might be a promising new agent for reducing penetrating intra-abdominal injury, with hemostatic and biocompatibility efficiency, and tissue preserving properties. Future effort of integrating it with a dispersal device may turn it into a valuable pre-hospital emergency tool to improve survival of trauma casualties.

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“…The levels of liver enzymes are well known to correlate with the degree of liver damage in various diseases including trauma (34,35). In our study the levels of ALT, AST and LDH were higher in the control group when monitoring ended, suggesting prevention of liver injury by VLVG.…”

Section: Discussionmentioning

confidence: 99%

Sodium Alginate as Treatment for Penetrating Abdominal Trauma- Feasibility Study.

Barsky

Ya’acov

Avraham

et al. 2020

Preprint

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Introduction: Penetrating abdominal injury is a major cause of death in trauma. It may cause hypovolemia leading to tissue hypoperfusion, direct organ damage and cytokine activation that cause inflammatory damage, all of which lead to death. Alginate is a natural anionic polysaccharide typically derived from brown algae. Sodium alginate hydrogel, a hemostatic agent, offers a platform for targeting both mechanical and biological injuries. The current study assessed the effect of a sodium alginate denoted VLVG (Very Low Viscosity (high) G alginate) following abdominal trauma in a swine model of penetrating abdominal injury. Methods: Seven anesthetized pigs were instrumented with catheters and abdominal trauma was introduced by laparoscopic hepatectomy. Ten minutes after the induction of hypovolemic shock, three animals were intra-abdominally administered with VLVG and four animals with saline (controls). During 8h of continuous monitoring, various hemodynamic and biochemical variables were measured and liver biopsies for histological evaluation were taken. In order to compare the study group to the control in a specific time a-parametric Mann-Whitney test was used, assessment of tendency during time Friedman's test for a-parametric variables was used. In order to compare the effect of the treatment (i.e. normal saline VS VLVG alginate) repeated measures ANOVA model was used, and the p value was calculated based on the Greenhouse-Geiser test. This research was approved by the Hebrew University of Jerusalem ethics Committee number: MD16148533. Results: VLVG-treated animals were more hemodynamically stable vs controls as reflected by their lower heart rate and higher blood pressure. They also had lower levels of liver enzymes and lactate and tissue damage. Conclusions: Our results in this pilot abdominal injury model show that VLVG might be a promising new agent. The superior hemostatic and biocompatibility efficiency along with its tissue preserving properties may turn VLVG in the future to a device that could be used in the pre-hospital setting to improve survival of abdominal trauma injuries.

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Liver trauma grading and biochemistry tests

Cited by 6 publications

References 6 publications

The Factors Associated With Decreasing Hemoglobin Levels and Platelet Counts After Trauma

The Factors Associated With Decreasing Hemoglobin Levels and Platelet Counts After Trauma

A feasibility study using sodium alginate injection for penetrating abdominal trauma in a swine model

Sodium Alginate as Treatment for Penetrating Abdominal Trauma- Feasibility Study.

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