Liver transplantation in Romania – retrospective analysis of 300 cases

Popescu, Irinel; Ionescu, M; Brasoveanu, Vladislav; Hrehoreţ, Doina; Matei, Emil; Dorobanţu, Bogdan; Zamfir, Radu; Alexandrescu, Sorin; Grigorie, M.; Tulbure, D; Popa, Laura; Ungureanu, Maria-Christina; Cristea, A. Ioana; Gheorghe, L.; Smira, Gabriela; Iacob, Silvia Elena; Boroș, Mirela; Lupescu, Ioana Gabriela; Vlad, L; Herlea, Vlad; Croitoru, Marian; A, Alloub

doi:10.2478/v10206-011-0011-x

Cited by 2 publications

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“…Expert consensus determined that the number of liver transplants in 2014 was 124, a slight increase from the reported 122 transplants in 2013. Between 2000 and 2011, 27% of transplants in Romania were attributable to HCV .…”

Section: Resultsmentioning

confidence: 99%

Historical epidemiology of hepatitis C virus (HCV) in select countries – volume 3

Liakina

Salehiniya

Tanaka

et al. 2015

Journal of Viral Hepatitis

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117

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SUMMARY. Detailed, country-specific epidemiological data are needed to characterize the burden of chronic hepatitis C virus (HCV) infection around the world. With new treatment options available, policy makers and public health officials must reconsider national strategies for infection control. In this study of 15 countries, published and unpublished data on HCV prevalence, viraemia, genotype, age and gender distribution, liver transplants and diagnosis and treatment rates were gathered from the literature and validated by expert consensus in each country. Viraemic prevalence in this study ranged from 0.2% in Iran and Lebanon to 4.2% in Pakistan. The largest viraemic populations were in Pakistan (7 001 000 cases) and Indonesia (3 187 000 cases). Injection drug use (IDU) and a historically unsafe blood supply were major risk factors in most countries. Diagnosis, treatment and liver transplant rates varied widely between countries. However, comparison across countries was difficult as the number of cases changes over time. Access to reliable data on measures such as these is critical for the development of future strategies to manage the disease burden.

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Section: Resultsmentioning

confidence: 99%

Historical epidemiology of hepatitis C virus (HCV) in select countries – volume 3

Liakina

Salehiniya

Tanaka

et al. 2015

Journal of Viral Hepatitis

Self Cite

117

View full text Add to dashboard Cite

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“…In Romania, HCV infection has been identified as the main cause of chronic hepatitis (64%) and liver cirrhosis (59%) [19] and it is the leading indication for liver transplantation (LT), accounting for 31.5% of all LT procedures performed in our program in 2012 [20]. Most HCV infected patients remain usually asymptomatic or have only mild nonspecific symptoms until the liver disease advances and its complications occur; consequently, diagnosis of HCV infection is usually performed by incidental detection of abnormal laboratory markers (mildly elevated aminotransferases) or of HCV infection (anti-HCV antibodies).…”

Section: Introductionmentioning

confidence: 99%

Position Paper on Treatment of Hepatitis C in Romania, 2017. Part One

Gheorghe

Sporea

Iacob

et al. 2017

JGLD

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Background & Aims: Hepatitis C Virus (HCV) infection is a common condition with endemic prevalence in some areas of the world. In Romania, the mean prevalence is about 3%. New treatments became available on the market in recent years and new drugs are in the pipeline. A re-evaluation of HCV therapy was considered mandatory. The Romanian Society of Gastroenterology and Hepatology undertook this task for the practitioners of this country.Methodology: A group of recognized experts was created who screened the available literature and the major available guidelines. A list of items requiring attention has been created. These items were discussed and rated. Decisions were taken by consensus.Recommendations: We present here the first of the two parts of our Society’s recommendations for chronic HCV infection treatment. An agreement was reached regarding the diagnostic tools, the assessment of severity and the up-dated therapy schedules.Conclusions: This Position Paper represents a guide for the assessment and the therapy of HCV infection. The recommendations are in concordance with other guidelines but are applied to the real-life conditions in this country.Abbreviations: DAAs: Direct-acting antivirals; DDIs: Drug-drug interactions; ESLD: End-stage liver disease; ESRD: End-stage renal disease; eGFR: Estimated glomerular filtration rate; EASL: European Association for the Study of the Liver; EMA: European Medicines Agency; FDA: US Food and Drug Administration; FDC: Fixed-dose combination; GT: Genotype; GRADE: Grading of Recommendations Assessment, Development and Evaluation; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; LT: Liver transplantation; LLD: Lower limit of detection; MELD score: Mayo-Clinic End-Stage Liver Disease score; ANMDM: National Agency of Medicines and Medical Devices; PPIs: Proton pump inhibitors; PWID: People who inject drugs; RCT: Randomized controlled trial; RDT: Rapid diagnostic test; RAS: Resistance-associated substitution; SRGH: Romanian Society of Gastroenterology and Hepatology; SAE: serious adverse events; SPC: Summary of Product Characteristics; SVR: Sustained virologic response.

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Liver transplantation in Romania – retrospective analysis of 300 cases

Cited by 2 publications

References 0 publications

Historical epidemiology of hepatitis C virus (HCV) in select countries – volume 3

Historical epidemiology of hepatitis C virus (HCV) in select countries – volume 3

Position Paper on Treatment of Hepatitis C in Romania, 2017. Part One

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