Liver transplantation for wilson's disease: A single-center experience

Eghtesad, Bijan; Nezakatgoo, Nosratollah; Jabbour, Nicolas; Irish, William; Marsh, Wallis; Fung, John J.; Rakela, Jorge

doi:10.1002/lt.500050614

Cited by 95 publications

(47 citation statements)

References 34 publications

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“…Liver transplantation is a good option for decompensated liver cirrhosis, fulminant hepatic failure, or advanced neurological manifestations. 11,12 We experienced a case of decompensated liver cirrhosis, and this patient (case 11) underwent liver transplantation. This patient had renal failure, and we therefore had to avoid the administration of D-penicillamine.…”

Section: Discussionmentioning

confidence: 98%

Recent clinical features of Wilson?s disease with hepatic presentation

et al. 2004

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Section: Discussionmentioning

confidence: 98%

Recent clinical features of Wilson?s disease with hepatic presentation

et al. 2004

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“…8 Whether improvement with MR abnormalities as severe as in our patient is possible at all is not known, although similar clinical deficits in Wilson disease have almost resolved after transplantation. 9,10 Because of its infrequent occurrence, the interpretation of MR imaging abnormalities-reversible or irreversible-has been far from precise. Other postoperative concerns include poor mobilization because of ataxia, risk of aspiration caused by hypokinesis, and possibly delirium.…”

Section: Descriptionmentioning

confidence: 99%

Acquired (non-Wilsonian) hepatocerebral degeneration: Complex management decisions

Wijdicks

Wiesner

2003

Liver Transplantation

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Portal systemic encephalopathy, in its many guises, can be reversible after medical management or liver transplantation. It is much less certain whether patients with a longstanding neurodegenerative syndrome (known in the medical vernacular as acquired hepatocerebral degeneration) can improve. Impressive neuroimaging abnormalities have been reported in this entity. 1 However, the combination of a severe disabling neurologic deficit and widespread magnetic resonance abnormalities tempers the enthusiasm of transplant surgeons to proceed with liver transplantation. In our liver transplantation program, we were recently confronted with such a case, and present herein not only the characteristic magnetic resonance imaging findings but also some of the dilemmas of management. (Liver Transpl 2003;9:993-994.)

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“…Nazer et al (138) predicted that those with elevations in bilirubin, prothrombin time and serum GOT had a poor prognosis when treated with medical management. fulminant or subfulminant hepatic failure and 73.3% of these patients survived more than 5 years after transplantation (140). Similarly, Sevmis and colleagues studied 24 patients with Wilson's disease.…”

Section: Treatment For Wilson's Diseasementioning

confidence: 99%