Liver transplantation for hepatocellular carcinoma: evaluation of the alpha‐fetoprotein model in a multicenter cohort from Latin America

Abstract

The AFP model could be useful in Latin-American countries to better select patients for LT in subgroups presenting with extended criteria. However, particular attention should be focused on patients with HBV.

Limitations of predicting microvascular invasion in patients with hepatocellular cancer prior to liver transplantation

“…Despite the advantages, its wide use remains limited by the relative shortage of organs procured from deceased donors2. Selection of patients based on the Milan criteria is associated with 5-year survival and recurrence rates of approximately 60–80% and 10–20%, respectively345. Although they remain the benchmark for patient selection, the long-term post-transplant outcomes of HCC patients are generally lower than that observed for patients with benign indications6.…”

Enfermedad hepática y dislipemia como manifestación de deficiencia de lipasa ácida lisosomal (LAL-D). Aspectos clínicos, diagnósticos y nuevo tratamiento. Actualización

“…42 En pediatría, de 5% a 15% de los casos de cirrosis son criptogénicos y, tanto en niños como en adultos, debe incluirse la investigación de LAL-D.…”

Liver disease and dyslipidemia as a manifestation of lysosomal acid lipase deficiency (LAL-D). Clinical and diagnostic aspects, and a new treatment. An update

“…42 In pediatrics, 5-15% of cirrhosis cases are cryptogenic, and LAL-D should be included 43,35 In the case of early liver failure, LAL-D should be included in screening tests in addition to tyrosinemia, galactosemia, beta-oxidation disorders, neonatal hemochromatosis, and mitochondrial diseases. 44,45 In the case of LAL-D, the histology of the liver shows cholesteryl ester accumulation in hepatocytes and Kupffer cells.…”