Liver Transplantation for Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors
Nicola De Stefano,
Damiano Patrono,
Fabio Colli
et al.
Abstract:Hepatocellular carcinoma (HCC) remains the leading oncological indication for liver transplantation (LT), with evolving and broadened inclusion criteria. Immune checkpoint inhibitors (ICIs) gained a central role in systemic HCC treatment and showed potential in the peri-transplant setting as downstaging/bridging therapy before LT or as a treatment for HCC recurrence following LT. However, the antagonistic mechanisms of action between ICIs and immunosuppressive drugs pose significant challenges, particularly re… Show more
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