Liver Transplantation for Benign Hepatic Tumors: A Systematic Review

Abstract

Orthotopic liver transplantation (OLT) has been performed for several benign hepatic tumors. Most of these diseases are usually managed conservatively, or treated by liver resection. OLT might be required when the lesions are symptomatic, diffuse in hepatic parenchyma, causing life-threatening complications or malignant transformation cannot be ruled out. Polycystic liver disease is the most common indication for OLT. We present a review of transplantable benign hepatic lesions to evaluate the need of OLT for these diseases, to summarize in which OLT is a good therapeutic option, and to show the early and long-term survival which might be expected.

Intrahepatic biliary cystadenoma—diagnosis and treatment options

“…Liver transplantation as a treatment modality can be considered in cystadenomas that cannot be completely removed technically, or large cystadenomas taking up a high volume of the liver (16,17). In these cases, a strictly individual approach is necessary, selecting the right treatment modality in line with the patient's preferences (18,19).…”

Liver transplantation for recurrent hepatic adenoma

“…In PubMed literature only 20 cases of LTx for HA are reported [1][2][3][4][5][6] . However up to 2008, United Network for Organ Sharing and European Liver Transplant Registry count 103 cases of LTx for HA which represent about 6%-11% all LTx performed for benign liver conditions and 0.085%-0.094% of all indications [18] . Literature highlights the risk of HCC development in the transplanted liver or lung metastasis [1] .…”

Hepatocellular Adenoma

“…In PubMed literature only 20 cases of liver transplantation for HA are reported [ 54 , 55 ]. However, up to 2008, United Network atransplantation for HA which represent about 6-11 % of all liver transplantation performed for benign liver conditions and 0.085-0.094 % of all indications [ 56 ].…”