Liver Transplantation for Acute Liver Failure due to Yellow Fever: A Case Report

Vieira, Vera Beatriz Guirland; Pacheco, Lucio; Demetrio, L.; Balbi, E.; Bellinha, T.; Toledo, Roxana; Auler, L.; Halpern, M. J.; Pinto, Lécio Figueira; Guaraldi, B.; Victor, Lívia; Bigi, J.; Carius, L.; Roma, J.

doi:10.1016/j.transproceed.2019.01.046

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Lipidosis has been diagnosed in human livers from YFV-infected patients. 8,16,19,23 Interestingly, Alouatta sp. had lower scores of lipidosis when compared with necrosis, which is likely due to the loss of most viable hepatocytes associated with the severe disease in this species.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic Patterns and Susceptibility of Neotropical Primates Naturally Infected With Yellow Fever Virus

Santos

Oliveira

Lucena³

et al. 2020

Vet Pathol

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Yellow fever is an important zoonotic viral disease that can be fatal for both human and nonhuman primates. We evaluated histopathologic changes in free-ranging neotropical primates naturally infected with yellow fever virus (YFV) compared with uninfected cohorts. The most frequent lesions in primates infected with YFV were hepatic changes characterized by midzonal necrosis with lipidosis and mild inflammation including lymphocytes, macrophages, plasma cells, and infrequently neutrophils. Importantly, severe necrotizing hepatic lesions were often observed in Alouatta sp. (howler monkeys), whereas Callithrix sp. (common marmosets) had nearly no hepatic changes. Moderate to severe hepatic necrosis was present in 21/23 (91%) of the YFV-positive Alouatta sp. compared with 10/29 (34%) of the YFV-positive Callithrix sp. ( P < .0001; odds ratio = 20). Similarly, hepatitis was more intense in Alouatta sp. compared with Callithrix sp. Furthermore, the frequency of YFV infection was significantly higher in Alouatta sp. compared with Callithrix sp. or Sapajus sp. (capuchin monkeys). Therefore, these data support the notion that Alouatta sp. is highly susceptible to infection and YFV-induced lesions, whereas Callithrix sp. is susceptible to infection but has a lower frequency of YFV-induced lesions.

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Section: Discussionmentioning

confidence: 99%

Histopathologic Patterns and Susceptibility of Neotropical Primates Naturally Infected With Yellow Fever Virus

Santos

Oliveira

Lucena³

et al. 2020

Vet Pathol

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“…Treatment consists of supportive care (93). Some case reports have described successful liver transplantation in YF patients with liver failure (94,95).…”

Section: Diagnostics and Treatmentmentioning

confidence: 99%

Exotic viral hepatitis: A review on epidemiology, pathogenesis, and treatment

Leeuwen

Jong

Doornekamp³

et al. 2022

Journal of Hepatology

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“…77 Two regions reported their experience with liver transplantation to manage fulminant hepatitis. 77,78 Because there are only a few reports on YF after KT, there is no robust information on the clinical presentation and prognosis in this population. To date, no blood or graft transmission has been reported in this population.…”

Section: Peculiarities Of the Most Frequent Tropical Infections In Kidney Transplant Patientsmentioning

confidence: 99%

Tropical Infections in the Context of Kidney Transplantation in Latin America

Requião-Moura

Daher

Albino

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Reports on tropical infections among kidney transplant (KT) recipients have increased in recent years, mainly because of the growing number of KT programs located in tropical and subtropical areas, and greater mobility or migration between different areas of the world. Endemic in emerging and developing regions, like most countries in Latin America, tropical infections are an important cause of morbidity and mortality in this population. Tropical infections in KT recipients may exhibit different pathways for acquisition compared with those in nonrecipients, such as transmission through a graft and reactivation of a latent infection triggered by immunosuppression. Clinical presentation may differ compared with that in immunocompetent patients, and there are also particularities in diagnostic aspects, treatment, and prognosis. KT patients must be screened for latent infections and immunized properly. Last, drug–drug interactions between immunosuppressive agents and drugs used to treat tropical infections are an additional challenge in KT patients. In this review, we summarize the management of tropical infections in KT patients.

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Liver Transplantation for Acute Liver Failure due to Yellow Fever: A Case Report

Cited by 3 publications

References 17 publications

Histopathologic Patterns and Susceptibility of Neotropical Primates Naturally Infected With Yellow Fever Virus

Histopathologic Patterns and Susceptibility of Neotropical Primates Naturally Infected With Yellow Fever Virus

Exotic viral hepatitis: A review on epidemiology, pathogenesis, and treatment

Tropical Infections in the Context of Kidney Transplantation in Latin America

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