Liver Transplantation for Acute Liver Failure Attributed to Leptospirosis: A Report of Two Cases

Lebreton, Thibault; Aubrun, Frédéric; Mabrut, Jean‐Yves; Heyer, Laurent; Perrin, Camille

doi:10.1155/2019/5189542

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Lebreton et al reported two cases of liver transplantation as a result of fulminant hepatic failure from leptospirosis [8]. Both cases had severe acute hepatitis with AST levels elevated to 16,650 and 17,000 IU/L, and ALT values of 7,900 and 9,500 IU/L.…”

Section: Discussionmentioning

confidence: 99%

Weil's Disease: A Rare Cause of Jaundice

Satiya¹,

Gupta²,

Parikh³

2020

Cureus

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Weil's disease is a complication of untreated leptospirosis and can be fatal. Awareness of leptospirosis and its hepatic manifestations are limited. We report the case of a 50-year-old man with gastrointestinal symptoms and a cholestatic pattern of liver injury diagnosed with Weil's disease. The patient showed remarkable improvement after treatment with appropriate antibiotics with normalization of liver function in one month. This case highlights the importance of recognizing leptospirosis and its myriad presentations.

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Section: Discussionmentioning

confidence: 99%

Weil's Disease: A Rare Cause of Jaundice

Satiya¹,

Gupta²,

Parikh³

2020

Cureus

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“…There are reports of liver transplantation because of liver failure by leptospirosis. 50 The gold standard for diagnosis of leptospirosis is the microscopic agglutination test with a 4-fold or more rise in titers in paired samples. IgM enzyme-linked immunosorbent assay (ELISA) is a more sensitive test, which is also used for screening but may be false negative in a transplant recipient.…”

Section: Clinical Features and Diagnosismentioning

confidence: 99%

South Asian Transplant Infectious Disease Guidelines for Solid Organ Transplant Candidates, Recipients, and Donors

et al. 2023

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These guidelines discuss the epidemiology, screening, diagnosis, posttransplant prophylaxis, monitoring, and management of endemic infections in solid organ transplant (SOT) candidates, recipients, and donors in South Asia. The guidelines also provide recommendations for SOT recipients traveling to this region. These guidelines are based on literature review and expert opinion by transplant physicians, surgeons, and infectious diseases specialists, mostly from South Asian countries (India, Pakistan, Bangladesh, Nepal, and Sri Lanka) as well as transplant experts from other countries. These guidelines cover relevant endemic bacterial infections (tuberculosis, leptospirosis, melioidosis, typhoid, scrub typhus), viral infections (hepatitis A, B, C, D, and E; rabies; and the arboviruses including dengue, chikungunya, Zika, Japanese encephalitis), endemic fungal infections (mucormycosis, histoplasmosis, talaromycosis, sporotrichosis), and endemic parasitic infections (malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis, strongyloidiasis, and filariasis) as well as travelers’ diarrhea and vaccination for SOT candidates and recipients including travelers visiting this region. These guidelines are intended to be an overview of each topic; more detailed reviews are being published as a special supplement in the Indian Journal of Transplantation.

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“…Because of factors such as population growth and poor health conditions, there has been an increase in the incidence of this disease. In addition, it has been reported that different types of Leptospira can and may require liver transplantation (32). The presence of conjunctival icterus, increased creatinine phosphokinase (CPK) levels, and less severe transaminitis suggests the presence of Weil's syndrome, rather than acute liver failure of a different etiology (33).…”

Section: Epidemiologymentioning

confidence: 99%

Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome

Chávez-Íñiguez

Cabrera-Aguilar

García-García

et al. 2020

jrenhep

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Leptospirosis is considered a zoonosis acquired predominantly from contaminated surfaces and water, more commonly in emerging countries with limited sanitary conditions. Leptospira in the host unleashes an immune response that explains the symptoms and clinical signs; once it reaches the kidney and liver tissue, it can manifest with alterations that lead to acute and chronic diseases in both organs. Weil’s syndrome is the best known clinical manifestation with jaundice and acute kidney injury that could lead to multiple organ failure and death. For its diagnosis, there are simplified scores such as the SPiRO score, the microbiological criteria by microscopy or serological tests; the treatment focuses on antibiotics and, if necessary, provides organic support until the infection is curtailed. The purpose of this review was to address the impact of Lep-tospira infection on the kidney and liver, the mechanisms of organ damage, the clinical presentation, and diagnosis and management of this disease.

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Liver Transplantation for Acute Liver Failure Attributed to Leptospirosis: A Report of Two Cases

Cited by 4 publications

References 7 publications

Weil's Disease: A Rare Cause of Jaundice

Weil's Disease: A Rare Cause of Jaundice

South Asian Transplant Infectious Disease Guidelines for Solid Organ Transplant Candidates, Recipients, and Donors

Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome

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