Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure

Gunadi, Gunadi; Gunawan, T.; Widiyanto, Galih; Yuanita, Amalia; Mulyani, Nenny Sri; Makhmudi, Akhmad

doi:10.1186/s13104-018-3498-z

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…The impact of ascites on morbidity and mortality is well known in adult cirrhotic patients [11,12,17], in whom 1-year and 2-year mortality are nearly 40% and 50%, respectively [17]. Only a very few prior studies have investigated presence of ascites as a prognostic factor in children with cirrhosis [8,22,23]. Pugliese et al [8] studied 522 pediatric patients with end-stage liver disease listed for LT due to several etiologies.…”

Section: Discussionmentioning

confidence: 99%

Severity of Ascites Is Associated with Increased Mortality in Patients with Cirrhosis Secondary to Biliary Atresia

et al. 2020

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Background Very few prior studies have investigated the presence of ascites as a prognostic factor in children with cirrhosis. To the best of our knowledge, there are no prior studies evaluating the relationship between severity of ascites and patient survival in children with biliary atresia and cirrhosis. Aims To evaluate the association between severity of ascites and survival of children with cirrhosis and biliary atresia. Methods All children with cirrhosis secondary to biliary atresia evaluated at our institution from 2000 to 2014 were included in this study. Patients were classified into four groups: NA = no ascites; A1 = grade 1 ascites; A2 = grade 2 ascites; and A3 = grade 3 ascites. The primary endpoint of the study was mortality within the first year after patient inclusion. Ninetyday mortality was also evaluated. Prognostic factors related to both endpoints also were studied. Results One-year patient survival for NA was 97.1%, versus 80.8% for A1, versus 52% for A2, versus 13.6 for A3 (p < 0.001). The presence of ascites increased mortality by 17 times. In the multivariate analysis, clinically detectable ascites (HR 3.14,

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Section: Discussionmentioning

confidence: 99%

Severity of Ascites Is Associated with Increased Mortality in Patients with Cirrhosis Secondary to Biliary Atresia

et al. 2020

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“…In addition, the combined model showed that, when probability >0.66, patients should be prepared for a poor outcome. Several noninvasive serological tests have been suggested to evaluate liver fibrosis in postoperative patients with BA, and determine the optimal timing of LT. 33,34 Serum matrix metalloproteinase-7 has been reported as a novel biomarker for diagnosing BA. However, it has a moderate accuracy of 78.1% for predicting LT. 1 Gunadi et al 33 and Zhen et al 34 developed a liver transplant score, including eight or nine parameters, some of which should be evaluated clinically.…”

Section: Discussionmentioning

confidence: 99%

Post-hepatoportoenterostomy Acoustic Radiation Force Impulse Elastography to Predict Two-year Outcome of Biliary Atresia

Zhao¹,

Li²,

Xie³

et al. 2022

J Clin Transl Hepatol

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Background and Aims:Early identification of prognostic factors to predict transplant/death outcome of biliary atresia (BA) is challenging. We aimed to investigate the longitudinal changes and predictive value of dynamic changes in acoustic radiation force impulse elastography with shear wave speed (SWS) quantification and other parameters within three months after hepatoportoenterostomy (HPE) for 2-year BA outcomes. Methods: Seventy-four patients who underwent

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“…Cholangitis is the most common complication in patients with BA after Kasai surgery, with an incidence of 30%-70% (Gunadi et al, 2018). Several studies have suggested that cholangitis may be a risk factor for poor prognosis in patients with post-Kasai BA (Jiang et al, 2018).…”

Section: Gut Microbiota and Bile Acid Profiles Are Associated With Ja...mentioning

confidence: 99%

Comprehensive Analysis of Gut Microbiota and Fecal Bile Acid Profiles in Children With Biliary Atresia

Yang

Shen

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundBiliary atresia (BA) is the most common cholestatic liver disease in neonates. Herein, we aimed at characterizing the gut microbiota and fecal bile acid profiles of BA patients, defining the correlations between them, and evaluating the relationship between the clinical pathogenesis and changes in the gut microbiota and bile acid profiles.MethodsA total of 84 fecal samples from BA patients (n = 46) and matched healthy controls (HCs, n = 38) were subjected to sequencing by 16S rRNA gene amplification, and fecal bile acid were analyzed by targeted metabolomics.FindingsCompared with the controls, a structural separation of the intestinal flora of BA patients was uncovered, which was accompanied by changes in the composition of fecal bile acids. In the BA group, Actinobacillus, Monoglobus, and Agathobacter were enriched in patients without cholangitis (p < 0.05). Selenomonadaceae and Megamonas were more abundant in patients without recurrent cholangitis episodes (p < 0.05), while Lachnospiraceae and Ruminococcaceae were enriched in patients with multiple recurrences of cholangitis (p < 0.05). Postoperative jaundice clearance was associated with Campylobacter and Rikenellaceae (p < 0.05), and tauroursodeoxycholic acid was associated with jaundice clearance (p < 0.001).ConclusionBA patients are characterized by different compositions of gut microbiota and bile acids, and their interaction is involved in the process of liver damage in BA, which may be closely related to the occurrence of postoperative cholangitis and jaundice clearance.

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Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure

Cited by 12 publications

References 21 publications

Severity of Ascites Is Associated with Increased Mortality in Patients with Cirrhosis Secondary to Biliary Atresia

Severity of Ascites Is Associated with Increased Mortality in Patients with Cirrhosis Secondary to Biliary Atresia

Post-hepatoportoenterostomy Acoustic Radiation Force Impulse Elastography to Predict Two-year Outcome of Biliary Atresia

Comprehensive Analysis of Gut Microbiota and Fecal Bile Acid Profiles in Children With Biliary Atresia

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