Liver transplant candidates have impaired quality of life across health domains as assessed by computerized testing

Stine, Jonathan G.; Stukenborg, George J.; Wang, Jennifer; Adkins, Alden; Niccum, Blake; Zimmet, Alex; Argo, Curtis K.

doi:10.1016/j.aohep.2019.06.018

Cited by 20 publications

(11 citation statements)

References 27 publications

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“…The computer adaptive tests, Patient‐Reported Outcomes Measurement Information System (PROMIS), use both generic and disease‐specific components. These are validated in the CLD population and may be the future of posttransplant population assessment as well 4,5 . The absence of uniformity in study designs and the wide variety of instruments have limited the widespread utility of HRQOL outcomes for decision making and long‐term follow‐up.…”

Section: Hrqol Instruments In the Post‐lt Populationmentioning

confidence: 99%

“…These are validated in the CLD population and may be the future of posttransplant population assessment as well. 4,5 The absence of uniformity in study designs and the wide variety of instruments have limited the widespread utility of HRQOL outcomes for decision making and long-term follow-up.…”

Section: Review Pain [Bp] General Health [Gh]) and Mental (Vitality [Vt]mentioning

confidence: 99%

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Beyond Survival: Targeting Health‐Related Quality of Life Outcomes After Liver Transplantation

Cristin

Forman

Jackson

2021

Clinical Liver Disease

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Liver transplantation (LT) is standard of care for patients with end-stage liver disease, with patient 1-and 5-year survival rates more than 90% and 70%, respectively. 1 As posttransplant survival improves, health-related quality of life (HRQOL) through patient reporting is an important independent measure to contextualize transplant outcomes. HrQOl insTrUMenTs in THe POsT-lT POPUlaTiOnHRQOL outcomes are subjective by their nature due to variable patient perceptions of wellness that may be influenced by cultural, social, and economic experiences and personal beliefs, expectations, and perceptions.Meaningful HRQOL assessment relies on translating qualitative perceptions of well-being into quantitative values for measurement and comparison. Properties of an effective instrument need to demonstrate reliability, validity, responsiveness; be of low burden to the respondent; and adapt to different cultures and languages. 2 A systematic review demonstrated more publications on LT and quality of life (QOL) since 2000 than in the prior two decades, with 128 articles using more than 50 QOL instruments. 3 The generic health instrument, Medical Outcomes Study Short-Form 36 (SF-36), is the most widely used instrument (54 of 128 studies), using 36 questions to derive 8 scales in physical (physical functioning, limitations because of physical health, bodily

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Section: Hrqol Instruments In the Post‐lt Populationmentioning

confidence: 99%

Section: Review Pain [Bp] General Health [Gh]) and Mental (Vitality [Vt]mentioning

confidence: 99%

Beyond Survival: Targeting Health‐Related Quality of Life Outcomes After Liver Transplantation

Cristin

Forman

Jackson

2021

Clinical Liver Disease

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“…Xiao et al showed that the anxiety score and depression score are significantly elevated in patients with minimal HE along with highest levels among CTP C subsettings (28) . Another report implicated that patients with MELD-Na score 20-29 exhibit significantly higher levels of anxiety and depression in comparison to those with MELD-Na< 10 (29) . Accordingly, the exclusion of patients with severe hepatic encephalopathy having difficulties to complete the EQ-5D questionnaire of the current study may give rise to selection bias.…”

Section: Discussionmentioning

confidence: 99%

The relationship between patient-reported health-related quality of life and malnutrition risk in cirrhosis: an observational cohort study

et al. 2022

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Patients with cirrhosis experience worse health-related quality of life (HRQoL), and attempts are warranted further exploration of modifiable factors to improve HRQoL. Data on the impact of malnutrition risk on HRQoL among cirrhosis are limited, thus we aimed to strengthen understanding by clarifying the relationship between nutritional status and low HRQoL in patients with decompensated cirrhosis. Consecutive inpatients with cirrhosis attending our department within a tertiary hospital were studied. Generic health profiles and malnutrition risk were evaluated by the EuroQol-5D (EQ-5D) and Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) score, respectively. Multiple linear regression analysis was used to determine association of malnutrition risk with low HRQoL. In this cohort of 364 patients with median age of 64 years and 49.5% male, 55.5% of the study population reported impairment pertinent to HRQoL in at least one dimension in terms of the EQ-5D. Moreover, malnutrition risk (RFH-NPT score: β coefficient = -0.114, P = 0.038) was proved to be independently associated with poor HRQoL in multiple analysis, after adjustment for significant variables like age, BMI, and markers of decompensation. Notably, we found that health dimensions representing physical function (i.e., mobility, self care and usual activities) are substantially affected, while malnourished patients reported less frequencies of complaints in other domain such as anxiety/depression. In conclusion, the risk of malnutrition assessed by the RFH-NPT score is independently associated with low HRQoL. It is operational to improve HRQoL by identifying patients at high malnutrition risk and providing timely nutrition treatment.

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“…Schließlich bleibt eine unzureichende Abbildung der Lebensqualität (healthrelated quality of life, HRQL) von Lebertransplantationskandidaten in diversen Bereichen wie kognitiver Funktion, Fatigue, Depressionen, körperlicher Funktion, aber auch sozialer Einbindung. Auch diese Faktoren, die die Lebensqualität beeinflussen und parallel zur Schwere der Erkrankung zunehmen, werden im MELD-Score bisher nicht ausreichend berücksichtigt [26].…”

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Evaluation und Notwendigkeit einer Anpassung des MELD Scores in der Eurotransplantregion

et al. 2021

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Liver transplant candidates have impaired quality of life across health domains as assessed by computerized testing

Cited by 20 publications

References 27 publications

Beyond Survival: Targeting Health‐Related Quality of Life Outcomes After Liver Transplantation

Beyond Survival: Targeting Health‐Related Quality of Life Outcomes After Liver Transplantation

The relationship between patient-reported health-related quality of life and malnutrition risk in cirrhosis: an observational cohort study

Evaluation und Notwendigkeit einer Anpassung des MELD Scores in der Eurotransplantregion

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