Liver transcriptome of rabbits supplemented with oral Moringa oleifera leaf powder under heat stress is associated with modulation of lipid metabolism and up-regulation of genes for thermo-tolerance, antioxidation, and immunity

Yasoob, Talat Bilal; Khalid, Abdur Rauf; Zhang, Zhen; Zhu, Xiaofeng; Hang, Suqin

doi:10.1016/j.nutres.2021.09.006

Cited by 9 publications

(8 citation statements)

References 72 publications

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“…The great protective effects of M. oleifera leaves extract against many diseases and the widely persistent environmental toxins, which disrupted cellular metabolic function have been confirmed (Hassan et al, 2021). Upregulation of genes for thermo-tolerance, antioxidation, and immunity over supplementing rabbits with oral M. oleifera leaf powder under heat stress was recorded indicating beneficial aspects on liver functions in heat-stressed rabbits (Yasoob et al, 2022). Moreover, up-regulation of the antiapoptotic BCL2A1 gene by M. oleifera leaves extract may suggest protection against apoptosis induced due to heat stress.…”

Section: Advances In Animal Andmentioning

confidence: 85%

“…It seems that the antioxidative properties of M. oleifera might help to maintain homeostasis under heat stress conditions (Yasoob et al, 2022). The partial pressure of oxygen was significantly increased in the Moringa groups compared to the control.…”

Section: Advances In Animal Andmentioning

confidence: 95%

“…One of the conditions that may contribute to higher CPK values is hyperthyroidism (Mccullough, 2019), which is expected to increase in the control group compared to M. oleifera groups due to higher thermo-tolerance responses. In addition, Yasoob et al (2022) indicated beneficial aspects of liver functions in heat-stressed rabbits upon M. oleifera supplementation. The antioxidant activity of M. oleifera leaf extract on the enzymatic activity of the liver in goats has been confirmed (Moyo et al, 2012).…”

Section: Hematology and Blood Biochemistrymentioning

confidence: 96%

“…M. oleifera extracts given to lambs as an anti-methane additive were proven to be effective in reducing intestinal methane emission (Akanmu et al, 2020). M. oleifera leaves powder when supplemented with rabbits during heat stress, resulting in reduced glucose, total cholesterol, low-density lipoprotein cholesterol, and triglycerides (Yasoob et al, 2022). Therefore, these plant extracts can be safely used as alternative food additives to reduce intestinal methane emissions and alleviate heat stress.…”

Section: Hematology and Blood Biochemistrymentioning

confidence: 99%

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Modulation Impacts of Moringa oleifera on Thermo Tolerance Parameters and Blood Indices in Subtropical Ewes under Heat Stress

Mufarji,

Mohammed,

Al Zeidi

et al. 2022

AAVS

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Appropriate strategies are required for the alleviation of heat stress resulting from global warming contributing to impaired metabolism and dysregulated immune and reproductive functions in animals. The aims of the current study were to investigate modulation impacts of moringa oleifera on thermo-tolerance parameters and blood indices in subtropical ewes under heat stress. Eighteen ewes with an average weight of 50.3 ± 1.80 kg and aged 2.5 -3.0 years were randomly allocated into three equal groups (six/group). The 1 st and 2 nd groups were assigned to Moringa oleifera treatments up to 50 and 100 g respectively and the 3 rd group was used as a negative control. The 1 st and 2 nd groups were subjected to heat stress for three hours from 12:00 to 3:00 pm for three consecutive days. Before and after heat stress; thermo-tolerance parameters (rectal temperature, respiration rate, pulse rate, and partial pressure of oxygen (SPO 2 ) were recorded, as well as, blood samples were collected and analyzed for hematological parameters and plasma biochemistry parameters. The results indicated that heat stress negatively influenced the thermo-tolerance, hematological, and plasma biochemistry parameters. M. oleifera alleviated the negative effects of heat stress, as well as modulated thermo-tolerance responses, metabolites, and liver and kidney functions. M. oleifera supplementation with a rate of 50 and 100 g to stressed ewes especially during high ambient temperatures and in subtropics is recommended.

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Section: Advances In Animal Andmentioning

confidence: 85%

Section: Advances In Animal Andmentioning

confidence: 95%

Section: Hematology and Blood Biochemistrymentioning

confidence: 96%

Section: Hematology and Blood Biochemistrymentioning

confidence: 99%

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Modulation Impacts of Moringa oleifera on Thermo Tolerance Parameters and Blood Indices in Subtropical Ewes under Heat Stress

Mufarji,

Mohammed,

Al Zeidi

et al. 2022

AAVS

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“…They revealed that the extract was not toxic to sheep as an anti-methane additive at a rate of 50 mg/kg DM. Yasoob et al (2022) reported that M. oleifera leaf powder when was supplemented to rabbits during heat stress resulted in reduced glucose, total cholesterol, low-density lipoprotein cholesterol, and triglycerides contributing to reduced intestinal methane emissions, alleviate heat stress, and increased meat yield. M. oleifera leaves may improve physiological parameters, and blood and plasma components.…”

Section: Blood Biochemistrymentioning

confidence: 99%

Leverage of Moringa oleifera Supplementation on Performances, Biochemical, and Milk Profiles in Mammals

Masruri¹,

Zeidi²,

Mufarji³

et al. 2022

AAVS

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referred to as a miracle plant. M. oleifera is a nutritious and medicinal tree species-rich in protein, minerals, and vitamins. M. oleifera is a native plant in Pakistan, India, Bangladesh, and Afghanistan (Fahey, 2005). Supplementation of M. oleifera to animals and humans has received increased attention for its high contents of certain micro and macro-nutrients, which are important in medicine and nutrition for both humans and animals (Oyeyinka and Oyeyinka, 2018;Gupta et al., 2018). Leaves of M. oleifera are reported to contain substantial amounts of vitamins such as A, C, and E (Saini et al., 2014a,b;Hekmat et al., 2015), minerals such as potassium, calcium, magnesium, iron, copper, and manganese (Hekmat et al., 2015), nutrients such as protein, fiber, carotenoids, and tocopherols ( Jongrungruangchok et al., 2010;Moyo et al., 2011; Saini et al., 2014a,b). Some of the Moringa components are known to scavenge free radicals (DanMalam et al., 2001). Sub-

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Dietary Moringa oleifera leaf powder improves jejunal permeability and digestive function by modulating the microbiota composition and mucosal immunity in heat stressed rabbits

Khalid

Yasoob

Zhang

et al. 2022

Environ Sci Pollut Res

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Liver transcriptome of rabbits supplemented with oral Moringa oleifera leaf powder under heat stress is associated with modulation of lipid metabolism and up-regulation of genes for thermo-tolerance, antioxidation, and immunity

Cited by 9 publications

References 72 publications

Modulation Impacts of Moringa oleifera on Thermo Tolerance Parameters and Blood Indices in Subtropical Ewes under Heat Stress

Modulation Impacts of Moringa oleifera on Thermo Tolerance Parameters and Blood Indices in Subtropical Ewes under Heat Stress

Leverage of Moringa oleifera Supplementation on Performances, Biochemical, and Milk Profiles in Mammals

Dietary Moringa oleifera leaf powder improves jejunal permeability and digestive function by modulating the microbiota composition and mucosal immunity in heat stressed rabbits

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