Liver stiffness quantification in biopsy-proven nonalcoholic fatty liver disease patients using shear wave elastography in comparison with transient elastography

Taibbi, Adele; Petta, Salvatore; Matranga, Domenica; Caruana, Giovanni; Cannella, Roberto; Busè, Gabriele; Marco, V. Di; Midiri, Massimo; Bartolotta, Tommaso Vincenzo

doi:10.14366/usg.20147

Cited by 11 publications

(7 citation statements)

References 31 publications

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“…15 While recent studies have examined diagnostic performance of SWE methods in chronic liver disease, most have either utilized point SWE instead of 2D-SWE and/or included participants with a diverse range of liver disease etiologies. [15][16][17][18][19][20][21][22][23][24][25] Data on disease-specific accuracy and cutoff values of 2D-SWE for staging hepatic fibrosis in adults with NAFLD, 26 especially when compared with VCTE, [27][28][29] are limited.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of two-dimensional shear wave elastography and transient elastography in nonalcoholic fatty liver disease

Sharpton

Tamaki

Bettencourt

et al. 2021

Therap Adv Gastroenterol

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Introduction: Two-dimensional shear wave elastography (2D-SWE) and vibration-controlled transient elastography (VCTE) provide noninvasive assessment of hepatic fibrosis. We compared performance of 2D-SWE and VCTE for fibrosis detection in nonalcoholic fatty liver disease (NAFLD). Methods: We performed a prospective study of adults with NAFLD who underwent 2D-SWE, VCTE, and liver biopsy analysis (using Nonalcoholic Steatohepatitis Clinical Research Network scoring system). The primary outcome was hepatic fibrosis (stage ⩾ 1); secondary outcomes included dichotomized fibrosis stages. Area under receiver operating characteristic curve (AUROC) analyses were used to compare 2D-SWE and VCTE performance. Results: A total of 114 adults with a median BMI of 31.2 kg/m2 were included. The VCTE was better than 2D-SWE for the detection of fibrosis (AUROC: 0.81 versus 0.72, p = 0.03). The VCTE detected fibrosis stage 2, 3, or 4 with AUROCs of 0.86 (95% CI, 0.80–0.93), 0.91 (95% CI, 0.82–0.99), and 0.96 (95% CI, 0.91–1.00). The 2D-SWE detected fibrosis stage 2, 3, or 4 with AUROCs of 0.84 (95% CI, 0.76–0.92), 0.88 (95% CI, 0.81–0.96), and 0.93 (95% CI, 0.86–0.99). Conclusion: In a prospective study including more than 100 adults with NAFLD, we found VCTE to be more accurate than 2D-SWE in detecting fibrosis; these modalities, however, are comparable in assessing for higher stages of fibrosis.

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Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of two-dimensional shear wave elastography and transient elastography in nonalcoholic fatty liver disease

Sharpton

Tamaki

Bettencourt

et al. 2021

Therap Adv Gastroenterol

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“…Taibbi et al showed that the diagnostic performances of shear wave elastography (SWE) 10, SWE 5, and SWE 3, compared with TE, had no significant difference in both significant and advanced fibrosis. However, it was higher for SWE 5 and SWE 10 [15]. Sharpton et al found the diagnostic accuracy for detecting fibrosis lower for 2D SWE compared to VCTE, and this finding was particularly highlighted in those with higher BMI [20].…”

Section: Discussionmentioning

confidence: 97%

Accuracy of Ultrasonography vs. Elastography in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review

Geethakumari¹,

Kampa²,

Parchuri³

et al. 2022

Cureus

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Ultrasonography and elastography are the most widely used imaging modalities for diagnosing nonalcoholic fatty liver disease. This study aimed to assess and compare the diagnostic accuracy in patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search was done for the past seven years using Pubmed, Pubmed Central, Cochrane, and Google Scholar databases on Jun 29, 2022. Studies were included based on the following predefined criteria: observational studies, randomized controlled trial (RCT), comparative studies, studies using liver biopsy or MRI proton density fat fraction (MRI PDFF) as a reference standard, ultrasonography, and elastography with measures of their diagnostic accuracy like sensitivity (SN), specificity (SP), area under the receiver operating characteristic (AUROC) curve, and English language. The data were extracted on a predefined template. The final twelve eligible studies were assessed using the quality assessment of diagnostic accuracy tool (QUADS-2). Most studies focused on elastography techniques, and the remaining focused on quantitative ultrasonography methods like the controlled attenuation parameter (CAP) and attenuation coefficient (AC). Only one study was available for the evaluation of qualitative ultrasonography. MRI was generally found superior to other diagnostic tests for determining liver stiffness through magnetic resonance elastography (MRE) and steatosis through MRI PDFF. Data assessing the comparative diagnostic accuracy of the two tests were inconclusive.

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“…Liver fibrosis is one of the strong predictors of clinical outcomes in patients with NAFLD [33,34] . Recently, a systematic review claimed that liver fibrosis could also be found in general population with the prevalence of 1% to as high as 26% [9] .…”

Section: Discussionmentioning

confidence: 99%

Clinical predictive score for detecting nonalcoholic fatty liver disease with significant fibrosis in patients with metabolic syndrome

et al. 2021

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Liver stiffness quantification in biopsy-proven nonalcoholic fatty liver disease patients using shear wave elastography in comparison with transient elastography

Cited by 11 publications

References 31 publications

Diagnostic accuracy of two-dimensional shear wave elastography and transient elastography in nonalcoholic fatty liver disease

Diagnostic accuracy of two-dimensional shear wave elastography and transient elastography in nonalcoholic fatty liver disease

Accuracy of Ultrasonography vs. Elastography in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review

Clinical predictive score for detecting nonalcoholic fatty liver disease with significant fibrosis in patients with metabolic syndrome

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