Liver Stiffness Is Increased in Polycystic Ovary Syndrome and Related With Complement C1q/Tumor Necrosis Factor–Related Protein 3 Levels

Gulumsek, Erdinc; Peköz, Burçak Çakır; Koç, Ayşe Selcan; Aslan, Muhammed Zübeyir; Ozturk, Huseyin Ali; Arici, Fatih Necip; Sümbül, Hilmi Erdem

doi:10.1097/ruq.0000000000000537

Cited by 3 publications

(7 citation statements)

References 28 publications

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“…15,23 Shear wave elastography and pSWE techniques have been developed relatively recently and are used in many liver diseases other than thalassemia major. [10][11][12][13][14] A previous study reported that LS measurement with SWE could be performed successfully in children. 24 We could not find a study in the literature comparing the diagnostic performance of TE and pSWE examinations in both adults and children.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9] Shear wave elastography (SWE) and point shear wave elastography (pSWE) are noninvasive and cost-effective US examinations used to evaluate tissue elasticity and LS. [10][11][12][13][14] Shear wave elastography examinations provide more accurate LS measurement than TE examinations. 15 Only 1 study has shown that the LS value obtained by SWE can be used to detect liver fibrosis in adult thalassemia major patients.…”

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confidence: 99%

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Point Shear Wave Elastography Detected Liver Stiffness Increased in Pediatric Patient With Thalassemia Major

Tuncel,

Pekoz,

Koc

et al. 2024

Ultrasound Quarterly

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Transient elastography (TE) and point shear wave elastography (pSWE) are 2 elastographic ultrasound examinations used in liver stiffness (LS) measurement. It was shown that the LS value detected by TE in pediatric β-thalassemia major patients has increased, and there was no LS evaluation obtained with pSWE in literature. Thus, in this study, it was aimed to evaluate LS with pSWE examination in children with thalassemia major and to determine LS-related parameters in these patients. Sixty-three schoolchildren with a diagnosis of β-thalassemia major and 21 healthy controls between the ages of 7 and 18 years were included. In addition to routine anamnesis, physical examination, and laboratory examinations, renal and liver ultrasounds were performed. Liver stiffness values were measured by pSWE examination. Serum levels of urea, aspartate-aminotransferase, alanine-aminotransferase, iron, and ferritin were significantly higher in patients, and serum creatinine, iron binding capacity, and hemoglobin levels were found to be significantly lower (P < 0.05 for each). Liver stiffness values were significantly higher in patients compared with healthy controls. In linear regression analysis, serum iron and iron binding capacity values were found to be closely related with LS (P < 0.001 vs. β = 0.482 and P = 0.047 vs. β = 0.237, respectively). Liver stiffness values obtained by pSWE examination increase significantly in patients. According to the results of our study, in addition to the previously known TE method, we think that the LS evaluation obtained by pSWE, a new method that can make more accurate measurements, can be used in the possible early detection of target organ damage in children with thalassemia major.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Point Shear Wave Elastography Detected Liver Stiffness Increased in Pediatric Patient With Thalassemia Major

Tuncel,

Pekoz,

Koc

et al. 2024

Ultrasound Quarterly

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“…Liver stiffness is usually used in gastroenterology and hepatology clinics and is closely related to liver fibrosis. 12,13 Recently, some studies started to report increased LS levels in CHDs. 14 The first study to evaluate LS in ASD patients showed that there was a significant increase in LS, and this increase was substantially higher in the patients with ASD who also has Eisenmenger syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Occasionally, liver US may be performed to evaluate abdominal symptoms, Eisenmenger syndrome, or RV failure in patients with ASD-associated liver diseases. Liver stiffness is usually used in gastroenterology and hepatology clinics and is closely related to liver fibrosis 12,13 . Recently, some studies started to report increased LS levels in CHDs 14 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Liver Stiffness After Atrial Septal Defect Closure

Peköz¹,

Koc

Küçükosmanoğlu

et al. 2022

Ultrasound Quarterly

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In this study, we aimed to evaluate the liver stiffness (LS) values and the right ventricle (RV) functions after atrial septal defect (ASD) closure treatment. Sixty-six patients were included (38 female, 28 male) in the study. Patients were grouped into 3 subgroups (group I = 21 patients without ASD closure, group II = 38 patients who underwent ASD closure, and group III = 11 patients with ASD and Eisenmenger syndrome). After 1-year follow-up of the patients who underwent ASD closure, LS was assessed using the liver elastography technique. Echocardiographic changes and LS changes over time were compared. Absolute Δ-LS and Δ-liver size were found to be significantly decreased in group II compared with the other groups. While liver size, LS levels, RV and left ventricle (LV) dimensions, and tricuspid regurgitation pressure gradient were found to be significantly decreased; the tricuspid annular plane systolic excursion and the LV ejection fraction were significantly increased in group II. In addition, Δ-LV and Δ-RV dimensions and Δtricuspid regurgitation pressure gradient values were statistically sıgnıfıcant and Δ-tricuspid annular plane systolic excursion and LV ejection fraction values were statistically higher in group II compared with the other groups. In conclusion, our study demonstrates that the LS is another parameter, which significantly decreases in patients treated with ASD occluder devices and can be used as an objective follow-up parameter in addition to classic echocardiographic measurements.

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“…Hence, CTRP3 could have a positive role in regulating inflammatory response and improving insulin resistance. Previous studies have implicated a strong link between POCS and CTRP3 18 19 20 .…”

Section: Introductionmentioning

confidence: 97%

Clinical Diagnostic Values of C1q/TNF-Related Protein-3 for Polycystic Ovary Syndrome Women with Insulin Resistance

Zhao

Zhang

et al. 2023

Horm Metab Res

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Polycystic ovary syndrome (PCOS) is the most common disease caused by complex endocrine and metabolic abnormalities in women. Insulin resistance is considered an important pathophysiological factor in the pathogenesis of PCOS. Here we investigated the clinical values of C1q/TNF-related protein-3 (CTRP3) as predictive factor for insulin resistance. Our study included 200 patients with PCOS, among which 108 had insulin resistance. Serum CTRP3 levels were measured using enzyme-linked immunosorbent assay. Predictive values of CTRP3 for insulin resistance was analyzed using receiver operating characteristic (ROC) analysis. Correlations of CTRP3 to insulin levels, obesity measurements and blood lipid levels were determined using Spearman’s correlation analysis. Our data suggested that PCOS patients with insulin resistance had a higher obesity, lower high-density lipoprotein cholesterol, higher total cholesterol, higher insulin levels and lower CTRP3 levels. CTRP3 had a high sensitivity (72.22%) and specificity (72.83%). CTRP3 significantly correlated to insulin levels, body mass index, waist-to-hip ratio, high-density lipoprotein, and total cholesterol levels. The predictive value of CTRP3 in PCOS patients with insulin resistance was supported by our data. Our findings suggest that CTRP3 is involved in the pathogenesis and insulin resistance of PCOS, which indicates its value as an indicator for the PCOS diagnosis.

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Liver Stiffness Is Increased in Polycystic Ovary Syndrome and Related With Complement C1q/Tumor Necrosis Factor–Related Protein 3 Levels

Cited by 3 publications

References 28 publications

Point Shear Wave Elastography Detected Liver Stiffness Increased in Pediatric Patient With Thalassemia Major

Point Shear Wave Elastography Detected Liver Stiffness Increased in Pediatric Patient With Thalassemia Major

Evaluation of Liver Stiffness After Atrial Septal Defect Closure

Clinical Diagnostic Values of C1q/TNF-Related Protein-3 for Polycystic Ovary Syndrome Women with Insulin Resistance

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