Liver steatosis and chronic hepatitis C

Fiore, Giorgio; Fera, G; Napoli, Nicola; Vella, Francesco; Schiraldi, O

doi:10.1097/00042737-199602000-00006

Cited by 64 publications

(36 citation statements)

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“…Fibrosis was correlated with age, platelet, ALT, AST, GGT and MTHFR C677T; steatosis was correlated with fibrosis. All above findings are consistent with the literature [10][11][12][13][14][15][16][17][18][19][20][21]27]. …”

Section: Discussionsupporting

confidence: 93%

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Polymorphisms in methylenetetrahydrofolate reductase gene: Their impact on liver steatosis and fibrosis of chronic hepatitis c patients

Altıntaş¹,

Altintas²,

Sezgın³

et al. 2014

OJGas

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Section: Discussionsupporting

confidence: 93%

“…Most studies have reported approximately 50% prevalence of steatosis among patients undergoing a liver biopsy because of HCV [10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in methylenetetrahydrofolate reductase gene: Their impact on liver steatosis and fibrosis of chronic hepatitis c patients

Altıntaş¹,

Altintas²,

Sezgın³

et al. 2014

OJGas

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“…Although the numbers in this study were too small for meaningful statistical analysis, other studies have shown associations between being overweight and the presence of fibrosis, obesity, and steatosis and between steatosis and the degree of histological severity. 18,19 Although the possibility of very low level viral replication below the detection sensitivity of our assay (Յ100 genomic equivalents/HCV per mL) cannot be excluded nor indeed can the possibility of HCV replication at extrahepatic sites, we believe that the histological changes of the majority of serum PCR-negative individuals described in this study are probably more suggestive of nonspecific reactive changes, steatosis, or nonalcoholic steatohepatitis rather than chronic HCV. 20 Before the identification of HCV, mild degrees of liver inflammation were reported by pathologists as nonspecific reactive changes or nonspecific reactive hepatitis.…”

Section: Discussionmentioning

confidence: 75%

Intrahepatic hepatitis C viral RNA status of serum polymerase chain reaction–negative individuals with histological changes on liver biopsy

Barrett

2001

Hepatology

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Hepatitis C virus (HCV) infection is a major public health problem worldwide. 1 Diagnosis of HCV is based on serological detection of anti-HCV antibodies by enzyme-linked immunosorbent assay (ELISA) supplemented with recombinant immunoblot assay (RIBA) and detection of HCV RNA in serum by polymerase chain reaction (PCR), because anti-HCV antibodies alone cannot discriminate active from past infection. 2 Histological assessment is also important in assessing disease status. 3 For individuals testing anti-HCV positive but negative for HCV RNA in serum, the precise diagnosis remains unclear. Whether they have spontaneously resolved past infection or currently have active infection undetectable in serum but which could be detectable in liver, since viral levels have been demonstrated to be 10 4 -fold higher in liver than in serum, is unclear. [4][5][6][7][8] If the latter is true and low level active infection is present, then these individuals represent a group well suited for therapeutic intervention because a low viral load is accepted as a favorable prognostic factor for therapy. 9 Because few studies to date have investigated HCV RNA status in the liver of anti-HCV-positive serum HCV RNA individuals, it is important to assess intrahepatic HCV RNA status in these individuals to determine whether they have truly spontaneously resolved past infection or have current infection with similar clincial, histological, and virological profiles as serum PCR-positive patients. [4][5][6][7] The discovery in 1994 that HCV-contaminated anti-D immunoglobulin had been administered to Rhesus-negative women in 1977 and 1991 to 1993 led to a national screening program conducted by the Irish Blood Transfusion Service Board (BTSB). 10 As a result of this program, a large group of PCR-positive (n ϭ 490) and antibody positive PCR-negative individuals (n ϭ 526) were identified and referred to 6 designated Liver Centers for further evaluation. 10,11 The aim of this study was to assess the significance of histological changes in the liver of serum PCR-negative women who had undergone liver biopsy at this center by detailed investigation of clinical, histological, and intrahepatic HCV RNA status. For the purpose of comparison, some clinical and histological data from a large group of serum PCR-positive women who received HCV-contaminated anti-D over the same time period as the serum PCR-negative women is also presented. PATIENTS AND METHODSPatients. As a result of the national screening program, 100 PCRpositive and 96 PCR-negative women who had received HCV-contaminated anti-D were randomly referred to this center and constitute a representative cross-section of the total infected cohort.Of the 96 PCR-negative women, 42 (43.8%) were still RIBApositive and 6 (6.2%) had elevated ALT levels at the time of presentation. Symptoms, consisting mainly of fatigue and arthralgia dating from the time of inoculation were reported by 69 (71.9%) women. It

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“…Previous, less controlled work had suggested an association between obesity and hepatic steatosis. 25,26 Recent evidence suggests that HCV itself (through its core protein) may cause hepatic steatosis. 27,28 However, the importance of fat mass in the development of steatosis is emphasized by the fact that obese patients develop fatty liver even in the absence of HCV and alcohol use.…”

mentioning

confidence: 99%