Liver, spleen, and vessels: preliminary clinical results of CT with perfluorooctylbromide.

Bruneton, Jean-Noël; Falewee, M. N.; François, Ετιεννε; Cambon, P; Philip, Chepsy C; Riess, J. G.; Balu–Maestro, C.; Rogopoulos, A

doi:10.1148/radiology.170.1.2909093

Cited by 69 publications

(14 citation statements)

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“…However, alterations of the liver through PFCs were already described in the literature. Obviously, the reason is storage of PFCs in the hepatic Kupffer-cells [28][29][30][31][32] . Like in the actual investigation, Lutz et al showed an increase in plasma levels of ALAT and ASAT in their studies.…”

Section: Discussionmentioning

confidence: 99%

Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution

Wrobeln

Jägers

Quinting

et al. 2020

Sci Rep

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Artificial blood for clinical use is not yet available therefore, we previously developed artificial oxygen carriers (capsules) and showed their functionality in vitro and biocompatibility in vivo. Herein, we assessed the functionality of the capsules in vivo in a normovolemic hemodilution rat-model. We stepwise exchanged the blood of male Wistar-rats with medium either in the presence of capsules (treatment) or in their absence (control). We investigated tissue hypoxia thoroughly through online biomonitoring, determination of enzyme activity and pancreatic hormones in plasma, histochemical and immunohistochemical staining of small intestine, heart, liver and spleen as well as in situ hybridization of kidneys. After hemodilution, treated animals show higher arterial blood pressure and have a stable body temperature. Additionally, they show a more stable pH, a higher oxygen partial pressure (pO 2), and a lower carbon dioxide partial pressure (pCO 2). Interestingly, blood-glucose-levels drop severely in treated animals, presumably due to glucose consumption. Creatine kinase values in these animals are increased and isoenzyme analysis indicates the spleen as origin. Moreover, the small intestine of treated animals show reduced hypoxic injury compared to controls and the kidneys have reduced expression of the hypoxia-inducible erythropoietin mRNA. In conclusion, our capsules can prevent hypoxic tissue damage. The results provide a proof of concept for capsules as adequate erythrocyte substitute. The need to develop synthetic products for blood replacement has become more and more important during the last decades. On the one hand, the demographic change leads to increasing requirements for blood, and on the other hand, simultaneously the willingness for blood donation declines 1. Blood with its various characteristics fulfils many functions, recent developments of synthetic blood substitutes focus on its most important function: the transport of physiological gases, in particular of oxygen. Additional key requirements for artificial blood substitutes are optimal size, sterility, biocompatibility, and the ability to be stored without loss of functionality. Moreover, artificial oxygen carriers (AOCs) should have a long intravascular circulation time and universal usage independent of the blood group characteristics 2,3. There are two main approaches to realize the transport of essential gases. The first is the use of the physiological oxygen carrier hemoglobin (hemoglobin-based artificial oxygen carriers, HBOCs); a concept realized e.g. in the prominent product hemopure, that gained pharmaceutical approval in South Africa and Mexico. Further HBOCs (e.g. sanguinate) are currently tested in clinical trials 4. So far, most of the products showed severe side effects so that the manufacturing had to be stopped 5. The second is the work with synthetic materials like perfluorocarbons [perfluorocarbon-based artificial oxygen carriers (PFOCs)]. Depending on the actual partial pressure, PFOCs are able to solve gases physically 6...

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Section: Discussionmentioning

confidence: 99%

Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution

Wrobeln

Jägers

Quinting

et al. 2020

Sci Rep

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“…However, it has been demonstrated that it remains in the liver and spleen for several months after administration . In contrast, PFOB remains in the liver and spleen a 20‐fold shorter time , it has already been used in humans as an oxygen carrier , and the PFC fraction in the emulsion has been increased from 70% w/v to 90% w/v without compromising its stability . Therefore, it might be considered the best‐suited candidate for inflammation imaging in humans from a safety point of view.…”

Section: Discussionmentioning

confidence: 99%

Characterization of perfluorocarbon relaxation times and their influence on the optimization of fluorine-19 MRI at 3 tesla

et al. 2016

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Purpose: To characterize and optimize 19 F MRI for different perfluorocarbons (PFCs) at 3 T and to quantify the loss of acquisition efficiency as a function of different temperature and cellular conditions. Methods: T 1 and T 2 relaxation times of the commonly used PFCs perfluoropolyether (PFPE), perfluoro-15-crown-5-ether (PFCE), and perfluorooctyl bromide (PFOB) were measured in phantoms and in several different conditions (cell types, presence of fixation agent, and temperatures). These relaxation times were used to optimize pulse sequences through numerical simulations. The acquisition efficiency in each cellular condition was then determined as the ratio of the signal after optimization with the reference relaxation times and after optimization with its proper relaxation times. Finally, PFC detection limits were determined. Results:The loss of acquisition efficiency due to parameter settings optimized for the wrong temperature and cellular condition was limited to 13%. The detection limits of all PFCs were lower at 24°C than at 37°C, and varied from 11.8±3.0 mM for PFCE at 24°C to 379.9±51.8 mM for PFOB at 37°C. Conclusion: Optimizing 19F pulse sequences with a known phantom only leads to moderate loss in acquisition efficiency in cellular conditions that might be encountered in in vivo and in vitro experiments.

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“…However, although gadolinium compounds can be used as both MRI and CT contrast agents due to its chemical and physical properties, more research is needed to improve their efficacy as multimodal contrast agents 14 . Multimodal contrast agents based on perfluorooctyl bromide have been used for many years to help image the liver, spleen, and vasculature 13 , 24 . Barium sulfate is a common orally-taken contrast agent used for imaging of the gastrointestinal tract 25 .…”

Section: Radiopacity and The Application In Cvd Imagingmentioning

confidence: 99%

Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

Tian

Feng

et al. 2018

Acta Pharmaceutica Sinica B

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A review of radiopaque nano and polymeric materials for atherosclerosis imaging and catheterization procedures is presented in this paper. Cardiovascular diseases (CVDs) are the leading cause of death in the US with atherosclerosis as a significant contributor for mortality and morbidity. In this review paper, we discussed the physics of radiopacity and X-ray/CT, clinically used contrast agents, and the recent progress in the development of radiopaque imaging agents and devices for the diagnosis and treatment of CVDs. We focused on radiopaque imaging agents for atherosclerosis, radiopaque embolic agents and drug eluting beads, and other radiopaque medical devices related to catheterization procedures to treat CVDs. Common strategies of introducing radiopacity in the polymers, together with examples of their applications in imaging and medical devices, are also presented.

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Liver, spleen, and vessels: preliminary clinical results of CT with perfluorooctylbromide.

Cited by 69 publications

References 0 publications

Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution

Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution

Characterization of perfluorocarbon relaxation times and their influence on the optimization of fluorine-19 MRI at 3 tesla

Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

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