Liver-resident CD8+ T cells: Learning lessons from the local experts

Swadling, Leo; Pallett, Laura J.; Maini, Mala K.

doi:10.1016/j.jhep.2020.02.001

Cited by 4 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TRM cells often express CD69, integrins CD49a and CD103 that mediate long-term retention within tissues 11,12 . TRM cells within human liver can be further divided by CD103 expression into two subpopulations exhibiting substantial functional differences: CD103 -TRM cells (CD69 + CD103 -CD8 + T cells) and CD103 + TRM cells (CD69 + CD103 + CD8 + T cells) 13,14 . Upon antigen or cytokine stimulation, CD103 + TRM cells are stronger effectors than CD103 -TRM cells, exhibiting robust inflammatory sentinel activity and long-term survival (longevity) in pathologic livers 13,15 .…”

Section: Introductionmentioning

confidence: 99%

NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis

Huang¹,

Lyu²,

Qian³

et al. 2022

Journal of Hepatology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis

Huang¹,

Lyu²,

Qian³

et al. 2022

Journal of Hepatology

View full text Add to dashboard Cite

“…One explanation for liver-predominant infiltration by EBV-infected CD8+ T cells would be that these cells were trapped in the liver by ICAM-1 expressed on sinusoidal endothelial cells (8). Another possibility is that EBV infection and subsequent clonal proliferation might have occurred in a specific and highly hepatotropic T cell compartment, such as tissue-resident memory T cells (9).…”

Section: Discussionmentioning

confidence: 99%

Case Report: A Case of Epstein-Barr Virus-Associated Acute Liver Failure Requiring Hematopoietic Cell Transplantation After Emergent Liver Transplantation

et al. 2022

View full text Add to dashboard Cite

Hepatic manifestations of Epstein-Barr virus (EBV) infection are relatively common, mild, and self-limiting. Although fulminant hepatic failure has been reported in a few cases, the contributing factors are unclear. This report discusses a pediatric case of EBV-associated acute liver failure that required urgent liver transplantation; however, liver damage continued to progress post-liver replacement. Monoclonal CD8+ T cells that preferentially infiltrated the native and transplanted liver were positive for EBV-encoded small RNA, suggesting a pathophysiology similar to that of EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Therefore, subsequent chemotherapy and hematopoietic cell transplantation was conducted, which led to cure. This is the first case of EBV-associated acute liver failure that relapsed post-liver transplant. As such, it sheds light on an under-recognized clinical entity: liver-restricted hyperinflammation caused by EBV-infected monoclonal CD8+ T cells. This phenomenon needs to be recognized and differentiated from hepatitis/hepatic failure caused by EBV-infected B cells, which has a relatively benign clinical course.

show abstract

“…However, they had intermediate expression of CD49a and high expression of Eomes compared to their CD103 + counterparts; therefore, whether this population is a bona fide T RM cell population needs to be elucidated [46]. For this reason, Swadling et al referred to the CD103 − subpopulation as human liver CD69 + CD103 − CD8 + "T RM -like" cells [47].…”

Section: Human Liver Cd69 + Cd103 − Cd8 + T Rm -Like Cellsmentioning

confidence: 99%

Liver-Resident Memory CD8+ T Cells: Possible Roles in Chronic HBV Infection

Han

Shin

2020

IJMS

View full text Add to dashboard Cite

Achieving a functional cure for chronic hepatitis B virus (HBV) infection or complete elimination of HBV covalently closed circular DNA (cccDNA) has been challenging in the treatment of patients with chronic HBV infection. Although novel antivirals are being investigated, improving HBV-specific adaptive immune responses is also important for durable viral clearance. Tissue-resident memory CD8+ T (TRM) cells were recently reported as a T-cell population that resides in peripheral tissues and does not recirculate. TRM cells have been studied in the livers of mice and humans. Liver TRM cells have distinct characteristics compared to T cells in peripheral blood or other tissues, which may be associated with the unique microenvironment of the liver. In this review, we describe the characteristics of liver TRM cells and their implications in chronic HBV infection. We emphasize that liver TRM cells can be an immunotherapeutic target for the treatment of chronic HBV infection.

show abstract

Liver-resident CD8+ T cells: Learning lessons from the local experts

Cited by 4 publications

References 25 publications

NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis

NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis

Case Report: A Case of Epstein-Barr Virus-Associated Acute Liver Failure Requiring Hematopoietic Cell Transplantation After Emergent Liver Transplantation

Liver-Resident Memory CD8+ T Cells: Possible Roles in Chronic HBV Infection

Contact Info

Product

Resources

About