Liver Resection for Hepatocellular Carcinoma: a Multivariate Analysis of Factors Associated with Improved Prognosis. the Role of Clinical, Pathological and Surgical Related Factors

Abstract

The treatment of hepatocellular carcinoma should be both the most radical to obtain the best outcome and to reduce the recurrence's rate, and the most suitable according to the patient's condition, lesion's characteristics and underlying liver disease: because of the large number of factors affecting the outcome of Hcc, unfortunately, we are still far from an agreement upon a group of criteria useful to select the best candidates for liver resection.

Impact of postoperative complications on long-term outcome of curative resection for hepatocellular carcinoma

“…Hepatic resection for HCC is now considered a safe operation with a low surgical morbidity rate. The present study has shown improved survival after curative primary resection for HCC over a 15-year interval with the advancement of surgical techniques and postoperative care 5 . However, postoperative complications were independently associated with worse overall survival.…”

“…The hepatic resection techniques used have been described previously 5 . Briefly, the operation started with a bilateral subcostal incision or right subcostal incision with upward midline extension.…”

“…Although the mortality rate has improved significantly in recent years owing to the advancement of surgical techniques and better postoperative care 4 , the postoperative morbidity rate remains high 5 . Postoperative morbidity increases the risk of tumour recurrence and can affect long-term survival 6,7 .…”

LCSGJ-T Classification, 6th or 5th Edition TNM Staging Did Not Independently Predict the Long-Term Prognosis of HBV-Related Hepatocellular Carcinoma After Radical Hepatectomy

“…Comparatively speaking, all the evaluated staging systems employed similar clinical and pathological variables that were previously shown to be prognostic in HCC, such as tumor size, tumor number, and vascular invasion [27][28][29]. This might, at least to some intent, ensure the applicability of them in HCC.…”

Diagnosis and Management of Hepatocellular Carcinoma: Results of a Consensus Meeting of The Ottawa Hospital Cancer Centre

“…Specifically, these studies retrospectively analyzed patients with liver resection for hcc to glean information on the prognostic values of clinical, surgical, pathologic, and biologic factors affecting long-term outcome and intrahepatic recurrence [26][27][28][29][30][31] . For example, in a retrospective analysis, Ramacciato et al reported that viral cause of cirrhosis, presence of multiple nodules, and vascular invasion negatively affected recurrence rate and long-term survival 30 .…”