Liver resection for colorectal liver metastases with peri‐operative chemotherapy: oncological results of R1 resections

Abstract

R1 resections were associated with a higher risk of intra-hepatic and surgical margin recurrence but did not negatively impact survival suggesting that in the era of efficient chemotherapy, the risk of an R1 resection should not be considered as a contraindication to surgery.

Oncologic results of laparoscopic liver resection for malignant liver tumors

“…This prospective single-center experience of 123 patients demonstrates a complete resection rate of 94% per tumor and surgical margin recurrence of 1.6% in follow up. These results are comparable to those reported for open resection series in the literature [11][12][13][14].…”

Tumour biology of colorectal liver metastasis is a more important factor in survival than surgical margin clearance in the era of modern chemotherapy regimens

“…21 The authors furthermore reviewed the largest series having reported on survival rates after a CLM resection. 1,2,5,6,8,[22][23][24][25][26][27][28][29][30][31][32][33][34] Their assessment first showed that the impact of a R1 resection on survival has become progressively questionable over the last 10 years (Fig. 1).…”

Onco-Surgical Management of Liver Metastases from Colorectal Cancer

“…Moreover, recent papers have revealed that in patients who primarily underwent R1 resection (CLMs located in contact with intrahepatic vascular structures that should be preserved) and subsequently modern postoperative chemotherapy, the overall survival rates were similar to those observed in patients who underwent R0 resections ( p value > 0.05) [67,68].…”