Liver-related mortality in hepatitis delta patients: Russian single centre experience

Abdurakhmanov, Dzhamal; Yesmembetov, Kakharman; Rozina, Teona; Nikulkina, Elena; Tanaschuk, Elena

doi:10.1016/j.dld.2018.05.006

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…18 Hot spots sustained by immigrants and intravenous drug users (IVDUs) have been reported in Russia. 19,20 IVDUs are the group at highest risk of hepatitis D. 21 However, the HDV scenario is also changing in IVDUs in Europe, reflecting the impact of HBV vaccination and the success of harm reduction programmes. In Spain, the prevalence of anti-HD among active HBsAg-positive IVDUs declined from 30% in the 1990s to 4.2% in 2018.…”

Section: Hdv Infection In Europe and The Usmentioning

confidence: 99%

The changing context of hepatitis D

Rizzetto

Salehiniya

Negro

2021

Journal of Hepatology

108

117

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The global epidemiology of hepatitis D is changing with the widespread implementation of vaccination against hepatitis B. In high-income countries that achieved optimal control of HBV, the epidemiology of hepatitis D is dual, consisting of an ageing cohort of domestic patients with advanced liver fibrosis who represent the end stage of the natural history of HDV, and of a younger generation of immigrants from endemic countries who account for the majority of new infections. As observed in Europe in the 1980s, the distinctive clinical characteristic of chronic hepatitis D in endemic countries is the accelerated progression to cirrhosis and hepatocellular carcinoma. Despite some recent progress, the therapeutic management of HDV remains unsatisfactory, as most patients are not cured of HDV with currently available medicines. This review article describes the current epidemiology and clinical features of chronic hepatitis D, based on the literature published in the last 10 years.

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Section: Hdv Infection In Europe and The Usmentioning

confidence: 99%

The changing context of hepatitis D

Rizzetto

Salehiniya

Negro

2021

Journal of Hepatology

108

117

View full text Add to dashboard Cite

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“…In the European part of the country, the frequency of coinfection does not exceed 5% among HBsAg-positive individuals, 3 although higher rates have been reported in cohorts including immigrants and intravenous drug users (IVDUs). 4,5 In the Asian part of the country, there are several regions that are considered endemic for hepatitis D (Yakutia, Chukotka, and Tuva), where up to 20-45% of people with HBV are coinfected with HDV. 6,7 However, data on HDV prevalence and the clinical and virological characteristics of patients with hepatitis D in Russia were obtained from small samples that differ significantly from each other, and so are fragmentary and in need of updating.…”

Section: Introductionmentioning

confidence: 99%

“…In Russia, HDV is distributed unevenly. In the European part of the country, the frequency of coinfection does not exceed 5% among HBsAg‐positive individuals, 3 although higher rates have been reported in cohorts including immigrants and intravenous drug users (IVDUs) 4,5 . In the Asian part of the country, there are several regions that are considered endemic for hepatitis D (Yakutia, Chukotka, and Tuva), where up to 20–45% of people with HBV are coinfected with HDV 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Silent HDV epidemics culminates in high levels of liver cirrhosis in endemic region despite 20 years of HBV vaccination

Isaeva

Kyuregyan

Karlsen

et al. 2022

Journal of Viral Hepatitis

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The hepatitis delta virus (HDV) is believed to be a vanishing infection in countries with successful hepatitis B virus (HBV) vaccination programs. We assessed the current status of HDV infection in Tuva, a region of the Russia that has been highly endemic for HBV. The proportion of HDV‐infected patients among HBsAg‐positive patients in the regional registry in 2020 was 32.7% (786/2401). An analysis of the medical records of 514 HDV patients demonstrated that 37.5% (193/514) had liver cirrhosis at the first doctor's visit, and 7.4% of patients lived in families where another family member had HDV. All HDV patients were infected with genotype HDV‐1, 94.5% had HBV genotype D, and 5.5% had genotype A. A serosurvey conducted among 1170 healthy volunteers showed that the average detection rate of HBsAg with anti‐HDV was 1.0% (95% CI: 0.57–1.81%). No anti‐HDV positive samples were detected in participants aged under 30 years. The HBsAg/anti‐HDV positivity rate peaked at 7.4% in patients aged 50–59 years, which was significantly higher than in a similar age cohort surveyed in 2008 (1.6%, p < .0001). A Bayesian analysis showed that HDV circulation in Tuva resulted from two waves of introduction, the first in the 1810s (95% HPD: 1741–1834) from Central Asia, and the second in the 1960s (95% HPD: 1953–1979) from Russia. HBV has a much longer history of circulation in Tuva with the MRCA for the predominant genotype HBV‐D dated to 972 (95% HPD: 535–1253) for subtype D1, 1274 (95% HPD: 936–1384) for D2, and 1173 (95% HPD: 1005–1618) for D3. A SkyGrid reconstruction of population dynamics showed an increase in the intensity of HDV spread in recent decades. This situation shows the need for HDV screening and prevention measures among people living with HBV.

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Liver-related mortality in hepatitis delta patients: Russian single centre experience

Cited by 2 publications

References 8 publications

The changing context of hepatitis D

The changing context of hepatitis D

Silent HDV epidemics culminates in high levels of liver cirrhosis in endemic region despite 20 years of HBV vaccination

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