Liver Regeneration: Preliminary Report.

A contribution to the problem of biological activity of the intrahepatic portal bed in the pig

“…Mann, F ishback, Gay, Green [1931], Child, Barr, H olsw ade, H arrison [1953], Ce r n í [1961], Minar, K ratochvíl, Ce r n í [1961] have established th at liver regeneration is conditioned by an increase in the blood flow through the rem aining tissue. P artial extirpation of the liver with an E ck fistula is not followed by hyperplasia (Mann et al [1931], Child et al [1953]). The significance of haem odynam ics in norm al liver developm ent lias been shown by P odkovyrov [1953], and by K aman [1961].…”

Glycogen Storage Disease Treated by Portacaval Transposition

“…Both in our case and in that reported by Starzl et al, a child treated for type III glycogen storage disease, there has been considerable benefit following portacaval transposition. Portacaval transposition was designed as an experimental procedure to study liver metabolism (Child et al 1953). The operation consists of division of the vena cava and the portal vein, the ends being then crossed over and anastomosed.…”

Liver

“…The question has been discussed whether these changes are of a secondary character or whether they reflect a primary role of the liver in cold adaptation (192; d. 193). The hepatomegaly seen in some Eskimos is apparently related to diet alone (hypervitaminosis A) (194), Regeneration of liver following partial hepatectomy.-Regeneration does not depend specifically upon portal venous blood supply, but rather upon the total volume of blood flow re aching the liver (195,196). Liver plates two cells thick are invariably found in regions of liver regeneration and of mitosis [Elias (197) ; cf.…”