2020
DOI: 10.1038/s41575-020-0342-4
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Liver regeneration: biological and pathological mechanisms and implications

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Cited by 573 publications
(574 citation statements)
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References 195 publications
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“…One of the characteristics of the liver is its high regenerative capacity, which is demonstrated when it is damaged by liver diseases or partial hepatectomy. Recent studies have shown that the dedifferentiation of bile duct epithelial cells and mature hepatocytes plays an important role in liver regeneration [8][9][10][11][12]. Specifically, it has been shown that hepatocytes and bile duct epithelial cells decidualize into highly proliferative hepatic progenitors in injured mouse livers, which are characterized by (1) a phenotype that is positive for both hepatocyte and bile duct epithelial markers, (2) characteristic cell morphology, and (3) high proliferative capacity [13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…One of the characteristics of the liver is its high regenerative capacity, which is demonstrated when it is damaged by liver diseases or partial hepatectomy. Recent studies have shown that the dedifferentiation of bile duct epithelial cells and mature hepatocytes plays an important role in liver regeneration [8][9][10][11][12]. Specifically, it has been shown that hepatocytes and bile duct epithelial cells decidualize into highly proliferative hepatic progenitors in injured mouse livers, which are characterized by (1) a phenotype that is positive for both hepatocyte and bile duct epithelial markers, (2) characteristic cell morphology, and (3) high proliferative capacity [13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…All vertebrates also share a highly conserved evolution of the hepatic portalliver system (Subbotin, 2017). A fact is that the liver is the only parenchymal organ that regenerates up to the proper ratio with respect to body size, in contrast with other organs, which only partially regenerate (Michalopoulous and Bhushan, 2021).…”
Section: Factors Contributing To the High Regenerative Capacity Of Thmentioning
confidence: 99%
“…The regenerative capacity of the liver is a central aspect of its functionality. Not only can small functional lesions be easily repaired by newly proliferating tissue, but it also allows for simultaneous surgical resections of multiple lobes of the liver without permanent impairments [99]. To this day, multiple studies depict IL-22 as an important player in mediating wound healing and tissue regeneration [22].…”
Section: Liver Regenerationmentioning
confidence: 99%