Liver recipients harbouring anti-donor preformed lymphocytotoxic antibodies exhibit a poor allograft survival at the first year after transplantation: Experience of one centre

Antibody-mediated rejection in liver transplantation: Current controversies and future directions

“…In 2005, a retrospective analysis of 268 consecutive liver transplants demonstrated that the incidence of CR was not different in cross-match-positive recipients versus cross-match-negative recipients. 18 Despite this, graft survival was markedly decreased in crossmatch-positive recipients with a 1-year survival rate of merely 28.6%, although there were only 11 patients in this group. Most of the graft losses in this cohort were attributed to sepsis.…”

Risk and prevention of graft failure in patients with preexisting donor-specific HLA antibodies undergoing unmanipulated haploidentical SCT

“…5 Moreover, Ab-mediated rejection is a well-recognized cause of treatment failure in the field of solid organ transplantation. [6][7][8][9] Furthermore, novel solidphase immunoassays, including Luminex single-Ag assays that use purified preparations of molecules corresponding to a single HLA Ag, allow accurate identification and quantification of specific HLA antibodies. 10 Recent studies indicate that the risk for both Ab-mediated rejection and graft loss after kidney transplantation directly correlate with peak levels of donor-specific HLA antibodies (DSA), as measured by Luminex single-Ag assays.…”

Antibody Mediated Rejection

“…However, Muro et al (14) showed that among 14 patients with a CDC cross-match, the 1-yr graft survival rate was a very low 29%, compared with 72% for 254 negative patients. The CDC-positive cross-match was found in only 5% of the transplants, reflecting the general finding that liver transplant patients are not sensitized to as high a degree as kidney and heart transplant patients (15).…”