Liver Perfusion Changes Occurring During Pancreatic Islet Engraftment: A Dynamic Contrast-Enhanced Magnetic Resonance Study

Esposito, Antonio; Palmisano, Anna; Maffi, Paola; Malosio, Maria Luisa; Nano, Rita; Canu, Tamara; Cobelli, Francesco De; Piemonti, Lorenzo; Ironi, Gabriele; Secchi, Antonio; Maschio, Alessandro Del

doi:10.1111/ajt.12501

Cited by 10 publications

(4 citation statements)

References 30 publications

(43 reference statements)

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“…Another possibility to quantify perfusion with MRI is dynamic contrast-enhanced (DCE). It has, for example, been used to assess perfusion both in native pancreas in response to a glucose challenge [16] and in the setting of islets transplantation [17]. However, DCE-MRI requires the intravenous administration of a contrast agent (often gadolinium-based).…”

Section: Discussionmentioning

confidence: 99%

Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI

et al. 2019

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AimsPerfusion of the pancreas and the islets of Langerhans is sensitive to physiological stimuli and is dysregulated in metabolic disease. Pancreatic perfusion can be assessed by both positron emission tomography (PET) and magnetic resonance imaging (MRI), but the methods have not been directly compared or benchmarked against the gold-standard microsphere technique.MethodsPigs (n = 4) were examined by [15O]H2O PET and intravoxel incoherent motion (IVIM) MRI technique simultaneously using a hybrid PET/MRI scanner. The pancreatic perfusion was measured both at basal conditions and after intravenous (IV) administration of up to 0.5 g/kg glucose.ResultsPancreatic perfusion increased by 35%, 157%, and 29% after IV 0.5 g/kg glucose compared to during basal conditions, as assessed by [15O]H2O PET, IVIM MRI, and microspheres, respectively. There was a correlation between pancreatic perfusion as assessed by [15O]H2O PET and IVIM MRI (r = 0.81, R2 = 0.65, p < 0.01). The absolute quantification of pancreatic perfusion (ml/min/g) by [15O]H2O PET was within a 15% error of margin of the microsphere technique.ConclusionPancreatic perfusion by [15O]H2O PET was in agreement with the microsphere technique assessment. The IVIM MRI method has the potential to replace [15O]H2O PET if the pancreatic perfusion is sufficiently large, but not when absolute quantitation is required.

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Section: Discussionmentioning

confidence: 99%

Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI

et al. 2019

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“…Many previous studies have demonstrated the usefulness of the extended Kety model for studying liver tumors, in which the predominant blood supply comes from the hepatic arterial blood flow. (23)(24)(25) Possible correlations of pharmacokinetic parameters based on the two compartments with arterial and venous blood flows with histopathologic microvascular parameters should be the focus of future studies.…”

Section: Discussionmentioning

confidence: 99%

Correlation of quantitative dynamic contrast‐enhanced MRI with microvascular density in necrotic, partial necrotic, and viable liver tumors in a rabbit model

Moon

Kim

Choi

et al. 2016

J Applied Clin Med Phys

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The purpose of this study was to examine the correlation of quantitative dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) with microvessel density (MVD) in necrotic, partial necrotic, and viable tumors using a rabbit VX2 liver tumor model. Nine rabbits were used for this study. The complete necrotic area (CNA), partial necrotic area (PNA), and viable tumor area (VTA) of liver tumors were experimentally induced by radiofrequency ablation (RFA). DCE‐MRI data were processed based on the extended Kety model to estimate normalKtrans,normalvnormale and vp parameters. The boundaries among CNA, PNA, and VTA were delineated based on H&E stain images, and MVD was assessed for each subregion of each VX2 tumor based. There were no correlations between ph‐parameters (normalKtrans,normalvnormale, and normalvnormalp) and MVD for CNA. For PNA, the normalKtrans values were positively correlated with the MVD (r=0.8124,p<0.0001). For VTA, we found a positive correlation between normalKtrans values and the MVD (r=0.5743,p<0.05). Measuring from both the PNA and the VTA, mean normalKtrans values were positively correlated with mean MVD (r=0.8470,p<0.0001). In a rabbit VX2 liver tumor model, normalKtrans values correlated well with MVD counts of PNA and VTA in liver tumors.PACS number(s): 87.19.If MRI

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“…It also takes consideration of the fact that the concentration of contrast agent varies as time progresses, and acknowledges the exchange process of contrast agent inside and outside the vessels, thus describing certain hemodynamics information quantitatively, such as the generation and permeability of carcinoma capillaries (15). This technology has been applied to the grading and effect evaluation of certain malignant tumors, including glioma, breast carcinoma and prostate carcinoma (16)(17)(18). By analyzing variations in surrounding parameter values of a DCE-MRI pharmacokinetics model in patients with esophageal squamous carcinoma prior to and following chemoradiotherapy, the present study aimed to investigate the assessment and predictive abilities of an early response in primary esophageal carcinoma patients undergoing concurrent chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging

et al. 2015

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Abstract. The aim of the present study was to investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can predict an early response in primary esophageal carcinoma patients undergoing concurrent chemoradiotherapy. A total of 25 patients with who were pathologically confirmed stage II-III esophageal carcinoma underwent quantitative DCE-MRI prior to chemoradiotherapy, and at 3 weeks post-treatment, the quantitative parameters [K trans (volume transfer constant; the rate at which contrast agent distributes from the plasma to the EES), K ep (rate contrast; the rate at which the contrast agent that has diffused to the EES returns to the plasma) and V e (the contrast agent percentage in the space of the extracellular fluid)] were analyzed respectively. The 25 cases were categorized as a complete response (CR) or a partial response (PR). An independent samples Mann-Whitney U test was used to compare the quantitative parameters between CR and PR. A receiver operating characteristic curve (ROC) was used to determine the best predictor. In total, 17 patients were in the CR group and 8 patients were in the PR group. Pretreatment K trans , K ep and V e values were 0.54±0.17/min, 1.12±0.46/min and 0.37±0.14, respectively, in the CR group, and 0.40±0.21/min, 1.07±0.37/min and 0.40±0.22, respectively, in the PR group. There was a significant difference between the two groups for K trans , but there were no significant differences between the two groups for K ep and V e .The K trans , K ep and V e values at 3 weeks post-treatment were 0.33±0.11/min, 0.86±0.31/min and 0.66±0.05, respectively, in the CR group, and 0.62±0.22/min, 1.19±0.39/min and 0.45±0.19, respectively, in the PR group. The corresponding U values were -3.319, -1.719 and -2.628, respectively, and the P-values were 0.006, 0.119 and 0.021, respectively. The areas under the ROC curve of K trans prior to chemoradiotherapy, and of K trans and K ep at 3 weeks post-treatment were 0.648, 0.741 and 0.796, respectively. In conclusion, DCE-MRI can predict an early response in primary esophageal carcinoma following 3 weeks of concurrent chemoradiotherapy. K trans prior to chemoradiotherapy, and K trans and K ep at 3 weeks post-treatment are sensitive prediction parameters. IntroductionEsophageal carcinoma is a common disease, and >80% of cases occur in developing countries. In 2008, esophageal cancer was the eighth most common cancer worldwide and China was ranked with the fourth highest morbidity rate for esophageal cancer worldwide with a five-year survival rate of <40% (1). The early symptoms of the disease, which include difficulty swallowing and esophageal foreign body sensation, are not obvious, and thus the majority of patients are diagnosed at an advanced stage (2). At present, the most common diagnostic techniques involve the examination of esophageal function, and include imaging analysis and esophagoscopy (3). The current treatment methods for esophageal carcinoma include surgery, radiation therapy, chemotherapy, endoscopic ...

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Liver Perfusion Changes Occurring During Pancreatic Islet Engraftment: A Dynamic Contrast-Enhanced Magnetic Resonance Study

Cited by 10 publications

References 30 publications

Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI

Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI

Correlation of quantitative dynamic contrast‐enhanced MRI with microvascular density in necrotic, partial necrotic, and viable liver tumors in a rabbit model

Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging

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