Liver organoids: updates on generation strategies and biomedical applications
Sen Liu,
Chuanliang Cheng,
Liuyang Zhu
et al.
Abstract:The liver is the most important metabolic organ in the body. While mouse models and cell lines have further deepened our understanding of liver biology and related diseases, they are flawed in replicating key aspects of human liver tissue, particularly its complex structure and metabolic functions. The organoid model represents a major breakthrough in cell biology that revolutionized biomedical research. Organoids are in vitro three-dimensional (3D) physiological structures that recapitulate the morphological … Show more
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