Liver only metastatic disease in patients with metastatic colorectal cancer: Impact of surgery and chemotherapy

Abstract

Liver only metastatic disease is common in CRC and patients undergoing liver resection have improved long-term survival. Survival for a combined approach of chemotherapy and hepatic resection is similar to surgery alone. Patients not suitable for surgery with liver only disease have a poorer prognosis highlighting the need for improved liver-directed therapies and attempts to covert non-resectable to resectable disease if possible.

Colorectal Cancer Treatment and Survival: the Experience of Major Public Hospitals in South Australia over three Decades

“…This study illustrates the value of clinical cancer registries in Australia for monitoring differences in patterns of care and survival by stage (Neo et al, 2011;Due et al, 2012;Padman et al, 2013), and for providing complementary information data to population-based registry data (Coleman et al, 2011;Neo et al, 2011;Due et al, 2012;Padman et al, 2013;Beckmann et al, 2014b;Roder, 2014;Roder et al, 2014;Taheri et al, 2014;Roder, 2015). The electronic transfer of prognostic data from structured pathology reporting, and continuous updating of this reporting to account for new scientific evidence, will ensure that clinical registry data remain effective for assessing health-system performance Roder, 2015).…”

“…In addition, increased use of neo-adjuvant therapy would have increased the potential for complete resection for some cancers otherwise not able to be excised. There is also evidence that increased resection of hepatic and pulmonary metastases may be extending survivals (Neo et al, 2011;Due et al, 2012;Padman et al, 2013).…”

Factors Affecting Prognosis in Metastatic Colorectal Cancer Patients

“…Primary tumor resection is recommended even for stage IV patients (Samowitz et al, 2007;Chew et al, 2012;Padman et al, 2013;Yoon et al, 2014). In a study by Moghimi-Dehkordi et al it was determined that a surgical intervention targeting primary tumors was significantly associated with survival in univariate analysis but this significance diminished in multivariate analysis, leading to not being considered an independent prognostic factor.…”

A Case of Krukenberg Tumor Metastasized from Colon Cancer Subsequent to Synchronous Multiple Liver Metastasis

“…These studies suggest that ETS is an effective predictor of the success of conversion therapy. The long-term survival of our patient with Krukenberg tumors of CRC, and other similar patients, is therefore supported by improvements in systemic chemotherapy, the introduction of anti-angiogenic agents, and the utilization of advanced surgical strategies and equipment [11][12][13] .…”