Liver Metastases From Colorectal Cancer Treated With Conventional and Antiangiogenetic Chemotherapy

Anzidei, Michele; Napoli, Alessandro; Zaccagna, Fulvio; Cartocci, Gaia; Saba, Luca; Menichini, G; Marincola, Beatrice Cavallo; Marotta, Eugenio; Mare, Luisa Di; Catalano, Carlo; Passariello, Roberto

doi:10.1097/rct.0b013e318230d905

Cited by 58 publications

(18 citation statements)

References 28 publications

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“…Metastatic lesions to the liver have shown a significant increase in ADC values following systemic chemotherapy that precedes changes in lesion size 129,130 . Interestingly, a recent study by Marugami et al showed significant overlap in ADC values between responding and non-responding colorectal metastatic lesions following intra-arterial chemotherapy.…”

Section: Liver Applicationsmentioning

confidence: 99%

Diffusion-Weighted Imaging of the Liver

Lewis

Dyvorne

Cui

et al. 2014

Magnetic Resonance Imaging Clinics of North America

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SYNOPSIS Diffusion weighted MRI (DWI) is a technique that assesses the cellularity, tortuosity of the extracellular/extravascular space and cell membrane density based upon differences in water proton mobility in tissues. The strength of the diffusion weighting is reflected by the b-value. DWI using several b-values enables quantification of the apparent diffusion coefficient (ADC). DWI is increasingly employed in liver imaging for multiple reasons: it can add useful qualitative and quantitative information to conventional imaging sequences, it is acquired relatively quickly, it is easily incorporated into existing clinical protocols, and it is a non-contrast technique. DWI is useful for focal liver lesion detection and characterization, for the assessment of post-treatment tumor response and for evaluation of diffuse liver disease. ADC quantification can be used to characterize lesions as cystic/necrotic or solid and for predicting tumor response to therapy. Advanced diffusion methods such as IVIM (intravoxel incoherent motion) may have potential for detection, staging and evaluation of the progression of liver fibrosis and for liver lesion characterization. The lack of standardization of DWI technique including choice of b-values and sequence parameters has somewhat limited its widespread adoption.

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Section: Liver Applicationsmentioning

confidence: 99%

Diffusion-Weighted Imaging of the Liver

Lewis

Dyvorne

Cui

et al. 2014

Magnetic Resonance Imaging Clinics of North America

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“…Using radiofrequency ablation, decreased ADC was observed in the periphery of the ablation zone and correlated with local tumour progression [ 35 ] . Two studies found that for liver metastases of colorectal cancer, non-responding lesions had significantly lower pre-treatment mean ADCs than responding lesions [ 36 , 37 ] , but this was not confirmed in a third study [ 38 ] .…”

Section: Clinical Applications Of Dw-mri For Monitoring Treatment Resmentioning

confidence: 99%

Therapy response with diffusion MRI: an update

2012

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The efficiency of an oncological treatment regimen is often assessed by morphological criteria such as tumour size evaluated by cross-sectional imaging, or by laboratory measurements of plasma biomarkers. Because these types of measures typically allow for assessment of treatment response several weeks or even months after the start of therapy, earlier response assessment that provides insight into tumour function is needed. This is particularly urgent for the evaluation of newer targeted therapies and for fractionated therapies that are delivered over a period of weeks to allow for a change of treatment in non-responding patients. Diffusion-weighted MRI (DW-MRI) is a non-invasive imaging tool that does not involve radiation or contrast media, and is sensitive to tissue microstructure and function on a cellular level. DW-MRI parameters have shown sensitivity to treatment response in a growing number of tumour types and organ sites, with additional potential as predictive parameters for treatment outcome. A brief overview of DW-MRI principles is provided here, followed by a review of recent literature in which DW-MRI has been used to monitor and predict tumour response to various therapeutic regimens.

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“…A reduction in BF and BV was observed less than 48 hours after commencing antiangiogenic treatment in carcinoid liver metastases [ 21 ] . CP has been suggested as predictor of response in colorectal liver metastases [ 22 ] . The applicability of CTp has increased since the introduction of wider CT detectors and periodic spiral techniques allowing for 15–16-cm craniocaudal coverage with sufficiently short image frequency.…”

Section: Liver Metastasesmentioning

confidence: 99%

Functional imaging biomarkers for assessing response to treatment in liver and lung metastases

Bernardin¹,

O’Flynn²,

deSouza³

2013

Cancer Imaging

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Management of patients with metastatic cancer and development of new treatments rely on imaging to provide non-invasive biomarkers of tumour response and progression. The widely used size-based criteria have increasingly become inadequate where early measures of response are required to avoid toxicity of ineffective treatments, as biological, physiologic, and molecular modifications in tumours occur before changes in gross tumour size. A multiparametric approach with the current range of imaging techniques allows functional aspects of tumours to be simultaneously interrogated. Appropriate use of these imaging techniques and their timing in relation to the treatment schedule, particularly in the context of clinical trials, is fundamental. There is a lack of consensus regarding which imaging parameters are most informative for a particular disease site and the best time to image so that, despite an increasing body of literature, open questions on these aspects remain. In addition, standardization of these new parameters is required. This review summarizes the published literature over the last decade on functional and molecular imaging techniques in assessing treatment response in liver and lung metastases.

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Liver Metastases From Colorectal Cancer Treated With Conventional and Antiangiogenetic Chemotherapy

Abstract: Both CT-p and MR-DWI can detect therapy-induced modifications in lesion vascularization before significant changes in size are evident.

Cited by 58 publications

References 28 publications

Diffusion-Weighted Imaging of the Liver

Diffusion-Weighted Imaging of the Liver

Therapy response with diffusion MRI: an update

Functional imaging biomarkers for assessing response to treatment in liver and lung metastases

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