Liver metastases found by follow-up of patients operated on for colorectal cancer

Almersjö, O; Bengmark, S; Hafström, L

doi:10.1002/1097-0142(197603)37:3<1454::aid-cncr2820370329>3.0.co;2-d

Cited by 27 publications

(9 citation statements)

References 11 publications

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“…[1][2][3][4][5] At present, surgical resection is the most effective treatment for metastatic liver tumors. 7,8 The excision of small, apparently solitary metastatic lesions could be justified on the basis of the low operative risk and prolonged patient survival.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathologic and immunohistochemical study of early colorectal cancer with liver metastases

Okano¹,

Shimoda²,

Matsumura³

1999

Journal of Gastroenterology

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Seven (3.3%) of 213 patients who underwent surgery for early colorectal cancer (invasion limited to no deeper than the submucosa) at the National Cancer Center Hospital, Tokyo, between 1986 and 1995 had synchronous (2 patients) or metachronous (5 patients) liver metastases. The average period from surgical resection of the primary colorectal cancer to the diagnosis of liver metastases was 25 months (range, 0-52 months). The clinicopathologic and immunohistochemical features of the primary lesions in these patients were compared with these features in the lesions in consecutive patients with early colorectal cancer who had no evidence of liver metastases within at least 5 years after colorectal resection. Venous invasion was more frequent in the primary lesions with liver metastases than in those without liver metastases (57% vs 0%; P = 0.0035). Expression of p53 and CD44v9 was more frequent in the primary lesions with liver metastases (71% and 100%) than in those without metastases (56% and 72%). In contrast, MUC2 expression was more frequent in the primary lesions without liver metastases (72%) than in those with metastases (43%). Venous invasion is considered to be closely related to liver metastasis, and the immunohistochemical expression of p53 and CD44v9 provides useful information for identifying those patients with early colorectal cancer who have a high risk of developing liver metastases.

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Section: Discussionmentioning

confidence: 99%

“…1,2 As the prognostic assessment of colorectal cancer relies mainly on TNM staging and histologic features, it is important to identify those patients who have a high risk of liver metastasis. Liver metastases are found even in patients with early colorectal cancer (invasion limited to no deeper than the submucosa).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic and immunohistochemical study of early colorectal cancer with liver metastases

Okano¹,

Shimoda²,

Matsumura³

1999

Journal of Gastroenterology

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“…37 Our findings suggests that E-selectin and sLe a may be associated with the process of hematogenous metastasis from colorectal cancer.…”

Section: Discussionmentioning

confidence: 56%

Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer

Ito

Hibi

et al. 2001

Journal of Gastroenterology

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“…Synchronous and metachronous liver metastases are found in 20% - 25% and 35% - 55% of patients with advanced colorectal cancer, respectively (1, 2). Liver resection provides a 30% - 40% increase in the 5-year survival rate when metastasis is found only in the liver (3).…”

Section: Introductionmentioning

confidence: 99%

Focal Sinusoidal Obstruction Syndrome Caused by Oxaliplatin-Induced Chemotherapy: A Case Report

et al. 2016

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IntroductionSinusoidal obstruction syndrome (SOS) is a severe adverse event of long-term chemotherapy in patients with colorectal cancer. It usually develops as liver congestion due to diffuse microscopic obstruction in liver parenchyma. In contrast, it sometimes appears as a liver mass occurring with local parenchymal hemorrhaging, and is often misdiagnosed as liver metastasis.Case PresentationA 40-year-old woman with rectal cancer underwent high anterior resection and partial liver resection of segment 7 due to synchronous liver metastasis. She received oxaliplatin-based chemotherapy (mFOLFOX6) as adjuvant chemotherapy for 6 months. A 13-mm irregular low-echoic mass was detected by CT in segment 3 of the liver 12 months after the operation. The mass was again resected as a liver metastasis because it had increased in size. The pathological diagnosis was focal SOS, which showed sinusoidal dilation and congestion by hepatocyte trabeculae in the liver parenchyma.ConclusionsAtypical irregular tumors should be considered as SOS when the patient has received oxaliplatin-based chemotherapy. A qualitative imaging modality diagnosis, such as with diffusion-weighted MRI, is superior to a morphological diagnosis in focal SOS. This imaging modality can prevent unnecessary operations.

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Liver metastases found by follow-up of patients operated on for colorectal cancer

Cited by 27 publications

References 11 publications

Clinicopathologic and immunohistochemical study of early colorectal cancer with liver metastases

Clinicopathologic and immunohistochemical study of early colorectal cancer with liver metastases

Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer

Focal Sinusoidal Obstruction Syndrome Caused by Oxaliplatin-Induced Chemotherapy: A Case Report

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