Liver mesenchymal neoplasms: something old, something new

Algashaamy, Khaled; Montgomery, Elizabeth A.; García-Buitrago, Mónica

doi:10.1016/j.pathol.2021.09.022

Cited by 4 publications

(2 citation statements)

References 59 publications

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“…The first mutation event (HIT) in TSC2 is a germline mutation, which is the cause of an individual TSC. The second ‘HIT’ event leads to excessive activation of mTORC1 (a mammalian target of rapamycin complex 1) and promotes tumor development[ 37 , 38 ]. The changes caused by these genes have been proven to be related to the etiology of PEComas.…”

Section: Treatment and Complicationsmentioning

confidence: 99%

Hepatic perivascular epithelioid cell tumors: The importance of preoperative diagnosis

Yan,

Lu,

Chen

et al. 2024

World J Gastroenterol

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Section: Treatment and Complicationsmentioning

confidence: 99%

Hepatic perivascular epithelioid cell tumors: The importance of preoperative diagnosis

Yan,

Lu,

Chen

et al. 2024

World J Gastroenterol

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“…Although HCC is the sixth most common cancer globally, HCC is the second leading cause of cancer-related deaths and its incidence is increasing worldwide [1, 3, 4]. In terms of mass-directed biopsies, HCC is the most frequently occurring liver lesion [5]. Majority of HCC patients are diagnosed at an advanced stage due to absence of signs and symptoms in the early stages, and the 5-year survival of HCC is dismal at 18-21% [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Multiomics data analysis identifies TM4SF4 as a cell surface target in hepatocellular carcinoma

Wong,

Ab. Hamid

2024

Preprint

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The clinical application of cellular immunotherapy in hepatocellular carcinoma (HCC) is impeded by the lack of a cell surface target frequently expressed in HCC cells and with minimal presence in normal tissues to reduce on-target, off-tumor toxicity. In thisin silicoanalysis, a longlist of genes (n=12,948) expressed in HCCs according to The Human Protein Atlas database were examined. The aim was to identify the optimal cell surface target, without being shed into circulation, in HCCs and with restrictive expression profile in other normal human tissues. A total of eight genes were shortlisted and they were subsequently ranked according to the combination of their transcript and protein expression levels in HCC cases (n=791) derived from four independent datasets (TCGA, CNHPP, GSE14520, and CHCC). TM4SF4 was the top-ranked target with the highest expression in HCCs. TM4SF4 demonstrated more favorable expression profile with significantly lower expression in normal human tissues but more highly expressed in HCC cases compared with seven other common HCC therapeutic targets. Furthermore, scRNA-seq (GSE149614 and GSE134355) and immunohistochemistry (HPA) datasets showed that TM4SF4 was absent in immune cell populations but highly expressed in the bile duct canaliculi of hepatocytes, a region that is inaccessible to immune cells. In scRNA-seq dataset of HCCs (GSE149614),TM4SF4expression was positively associated with mitochondrial components and oxidative phosphorylation Gene Ontologies in HCC cells (n=15,787 cells), suggesting its potential roles in mitochondrial-mediated oncogenic effects in HCC. Taken together, TM4SF4 is proposed as a promising cell surface target in HCC.

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Current concepts in gastrointestinal pathology

García-Buitrago

Montgomery

2022

Pathology

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Liver mesenchymal neoplasms: something old, something new

Cited by 4 publications

References 59 publications

Hepatic perivascular epithelioid cell tumors: The importance of preoperative diagnosis

Hepatic perivascular epithelioid cell tumors: The importance of preoperative diagnosis

Multiomics data analysis identifies TM4SF4 as a cell surface target in hepatocellular carcinoma

Current concepts in gastrointestinal pathology

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