Liver lipid metabolism disruption in cancer cachexia is aggravated by cla supplementation -induced inflammation

Gonçalves, Daniela Caetano; Lira, Fábio Santos; Yamashita, Alex Shimura; Carnevali, Luiz Carlos; Eder, Robson; Laviano, Alessandro; Seelaender, Marília

doi:10.1016/j.clnu.2018.09.023

Cited by 21 publications

(23 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in epididymal adipose tissue, tumor driven lipolysis was aggravated by CLA supplementation (95). More recently, in rats bearing the Walker 256 tumor, CLA treatment aggravated cachexia symptoms, including increased inflammatory status, steatosis and hyperlipidemia (96). Collectively, these results do not provide strong support for CLA in the treatment of cancer cachexia.…”

Section: Conjugated Linoleic Acidmentioning

confidence: 89%

Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models

et al. 2020

View full text Add to dashboard Cite

Cancer cachexia is a complex metabolic syndrome characterized by involuntary skeletal muscle loss and is associated with poor clinical outcome, decreased survival and negatively influences cancer therapy. No curative treatments are available for cancer cachexia, but nutritional intervention is recommended as a cornerstone of multimodal therapy. Optimal nutritional care is pivotal in the treatment of cancer cachexia, and the effects of nutrients may extend beyond provision of adequate energy uptake, targeting different mechanisms or metabolic pathways that are affected or deregulated by cachexia. The evidence to support this notion derived from nutritional intervention studies in experimental models of cancer cachexia is systematically discussed in this review. Moreover, experimental variables and readout parameters to determine skeletal muscle wasting and cachexia are methodologically evaluated to allow critical comparison of similar studies. Single- and multinutrient intervention studies including qualitative modulation of dietary protein, dietary fat, and supplementation with specific nutrients, such as carnitine and creatine, were reviewed for their efficacy to counteract muscle mass loss and its underlying mechanisms in experimental cancer cachexia. Numerous studies showed favorable effects on impaired protein turnover and related metabolic abnormalities of nutritional supplementation in parallel with a beneficial impact on cancer-induced muscle wasting. The combination of high quality nutrients in a multitargeted, multinutrient approach appears specifically promising, preferentially as a multimodal intervention, although more studies investigating the optimal quantity and combination of nutrients are needed. During the review process, a wide variation in timing, duration, dosing, and route of supplementation, as well as a wide variation in animal models were observed. Better standardization in dietary design, and the development of experimental models that better recapitulate the etiology of human cachexia, will further facilitate successful translation of experimentally-based multinutrient, multimodal interventions into clinical practice.

show abstract

Section: Conjugated Linoleic Acidmentioning

confidence: 89%

Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models

et al. 2020

View full text Add to dashboard Cite

show abstract

“…As described above, proinflammatory cytokines are increased in cancer cachexia and liver function is strongly affected by them. Animal models of cachexia revealed a large number of liver alterations: proinflammatory cytokines induced an increase in inflammatory mediators in the liver, mainly by Kupffer cells, leading to insulin resistance [ 58 ], cholestasis [ 59 ] and steatosis [ 60 ]. Tumor-induced inflammation has been shown to promote the alteration of liver circadian homeostasis, altering AKT, AMPK and SREBP signaling, as well as insulin and glucose homeostasis [ 61 ].…”

Section: Livermentioning

confidence: 99%

Cachexia, a Systemic Disease beyond Muscle Atrophy

Wyart

Bindels

Mina

et al. 2020

IJMS

View full text Add to dashboard Cite

Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the molecular drivers of such a condition is crucial for the development of management approaches. Importantly, cachexia is a syndrome affecting various organs, which often results in systemic complications. To date, the majority of the research on cachexia has been focused on skeletal muscle, muscle atrophy being a pivotal cause of weight loss and the major feature associated with the steep reduction in quality of life. Nevertheless, defining the impact of cachexia on other organs is essential to properly comprehend the complexity of such a condition and potentially develop novel therapeutic approaches.

show abstract

“…The liver was essential to regulate glucose and lipid metabolism (23,24), and the pathological state of liver was related with the abnormality of metabolism (25). Several studies have demonstrated that ectopic accumulation of lipid within liver could specifically cause hepatic insulin resistance in humans and rodents (26)(27)(28)(29).…”

Section: Introductionmentioning

confidence: 99%

Ovariectomy Impaired Hepatic Glucose and Lipid Homeostasis and Altered the Gut Microbiota in Mice With Different Diets

Lei

Yang

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

The lower incidence of metabolic diseases of women than men and the increasing morbidity of metabolic disorders of menopausal women indicated that hormones produced by ovaries may affect homeostasis of glucose and lipid metabolism, but the underlying mechanisms remain unclear. To explore the functions of ovaries on regulating glucose and lipid metabolism in females, 8 weeks old C57BL/6 mice were preformed ovariectomy and administrated with normal food diet (NFD) or high fat diet (HFD). Six weeks after ovariectomy, blood biochemical indexes were tested and the morphology and histology of livers were checked. The expression levels of genes related to glucose and lipid metabolism in liver were detected through transcriptome analysis, qPCR and western blot assays. 16S rDNA sequence was conducted to analyze the gut microbiota of mice with ovariectomy and different diets. The serum total cholesterol (TC) was significantly increased in ovariectomized (OVX) mice fed with NFD (OVXN), and serum low density lipoprotein-cholesterol (LDL-C) was significantly increased in both OVXN mice and OVX mice fed with HFD (OVXH). The excessive glycogen storage was found in livers of 37.5% mice from OVXN group, and lipid accumulation was detected in livers of the other 62.5% OVXN mice. The OVXN group was further divided into OVXN-Gly and OVXN-TG subgroups depending on histological results of the liver. Lipid drops in livers of OVXH mice were more and larger than other groups. The expression level of genes related with lipogenesis was significantly increased and the expression level of genes related with β-oxidation was significantly downregulated in the liver of OVXN mice. Ovariectomy also caused the dysbiosis of intestinal flora of OVXN and OVXH mice. These results demonstrated that hormones generated by ovaries played important roles in regulating hepatic glucose and lipid metabolism and communicating with the gut microbiota in females.

show abstract

Liver lipid metabolism disruption in cancer cachexia is aggravated by cla supplementation -induced inflammation

Cited by 21 publications

References 60 publications

Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models

Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models

Cachexia, a Systemic Disease beyond Muscle Atrophy

Ovariectomy Impaired Hepatic Glucose and Lipid Homeostasis and Altered the Gut Microbiota in Mice With Different Diets

Contact Info

Product

Resources

About