Liver lesions produced by aflatoxins in Rana catesbeiana (bullfrog)

Grassi, Thiago Luís Magnani; Pires, Paulo W.; Barbisan, Luı́s Fernando; Dal-Pai-Silva, Maeli; Said, Roueda Abou; Camargo, João Lauro Viana de

doi:10.1016/j.ecoenv.2006.07.007

Cited by 9 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…"content-markup(./author-grp [1]/aff|./author-grp [1]/dept-list)> Aflatoxins (AF) are a group of naturally occurring mycotoxins produced by Aspergillus fungi, especially Aspergillus flavus and Aspergillus parasiticus, which grow in a wide variety of improperly stored food commodities. 8 The ingestion of AF-contaminated food and feed is a matter of worldwide concern, which causes acute and chronic toxicosis in humans and domestic and laboratory animals. Aflatoxins are carcinogenic and are potent liver toxins.…”

mentioning

confidence: 99%

An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina

et al. 2008

View full text Add to dashboard Cite

Abstract. Chinchillas (Chinchilla lanigera) are known to be very sensitive to aflatoxins, and often a large number of animals die if toxicosis occurs. An outbreak of acute aflatoxicosis on a chinchilla farm in Argentina is described in the present study. A commercial feed suspected of causing the death of 200 animals was sampled. Livers from 9 dead chinchillas were analyzed for their macroscopic and microscopic characteristics via necropsy and histopathology. Aflatoxins B 1 , B 2 , G 1 , and G 2 were determined, by thin layer chromatography, to be in the feed. Macroscopic inspection of livers revealed general enlargement, paleyellowish coloration, hypertrophy, rounded borders, and increased friability. Size and color were remarkably different from a healthy organ. Histopathologic analyses of hepatic parenchyma showed severe, diffuse cytoplasmic vacuolation of hepatocytes. Sudan III staining confirmed the presence of lipid within the vacuoles. The feed was positive for aflatoxin B 1 in quantities that exceeded the recommended levels. Histologic lesions were typical of aflatoxin intake. Monitoring feed for mycotoxins is crucial to prevent outbreaks of toxicosis, to improve management practices, and to diminish exposure risk of animals and humans to these harmful toxins.

show abstract

mentioning

confidence: 99%

An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina

et al. 2008

View full text Add to dashboard Cite

show abstract

“…liver damage, teratogenesis, oxidative stress and immunosuppressive action), and these results were supported by various animal models . In several toxicological studies at relatively high concentrations of AFB1 contamination (≥1 mg kg −1 ), heavy damage to the liver and kidney was observed . However, to our knowledge, toxicological evaluation at concentrations corresponding to AF regulatory limits of various countries has rarely been carried out, even though such concentrations may still pose risks for animal production and human health.…”

Section: Discussionmentioning

confidence: 69%

Evaluation of toxicological impacts on Sprague–Dawley rat by successively low dose of aflatoxin B1

Wei¹,

Li²,

et al. 2014

J Sci Food Agric

View full text Add to dashboard Cite

show abstract

“…Likewise, the AFT-induced pathological effects have been described in some wild animals such as deer (Quist et al, 1997), and Rhesus monkeys (Madhavan et al, 1965). Aflatoxicosis has been successfully induced in experimental animals including mice (Kanbur et al, 2011), rats (Salmon and Newberne, 1963;Wei et al, 2014), rabbits (Abd El-Mageed, 1987Abd El-Hamid, 1990;Ibrahim, 2000), guinea pigs (Butler, 1966), frogs (Grassi et al, 2007) and chinchillas (Pereyra et al, 2008). Mice were comparatively resistant to aflatoxicosis while rats were highly susceptible (Ramsdell and Eaton 1990).…”

Section: B) Aflatoxicosis In Animals Birds and Aquaculture Speciesmentioning

confidence: 99%

Aflatoxins biosynthesis, toxicity and intervention strategies: A review

Int¹

2019

Preprint

View full text Add to dashboard Cite

Aflatoxins (AFTs) are toxic products of fungal metabolism, associated with serious health consequences and substantial economic losses to agriculture, livestock and poultry sectors, particularly in the developing countries. This review outlines the current information on AFTs in terms of historical background, classification, relative occurrence and co-existence with other mycotoxins in various food commodities. The phenomenon of aflatoxin (AFT) biosynthesis has been elucidated with reference to molecular basis, genetic regulation and factors affecting the AFT production. Moreover, the in vivo disposition kinetics, toxicological action and toxico-pathological consequences of AFTs have also been highlighted. Currently employed strategies for the detection and detoxification of AFTs, biomarkers of exposure assessment, potential economic impact and regulatory considerations regarding the AFTs have been emphasized.

show abstract

Liver lesions produced by aflatoxins in Rana catesbeiana (bullfrog)

Cited by 9 publications

References 22 publications

An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina

An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina

Evaluation of toxicological impacts on Sprague–Dawley rat by successively low dose of aflatoxin B1

Aflatoxins biosynthesis, toxicity and intervention strategies: A review

Contact Info

Product

Resources

About