Liver ischemia-reperfusion injury: From trigger loading to shot firing
Eric Felli,
Emanuele Felli,
Edoardo M. Muttillo
et al.
Abstract:An ischemia-reperfusion injury (IRI) results from a prolonged ischemic insult followed by the restoration of blood perfusion, being a common cause of morbidity and mortality, especially in liver transplantation. At the maximum of the potential damage, IRI is characterized by 2 main phases. The first is the ischemic phase, where the hypoxia and vascular stasis induces cell damage and the accumulation of damage-associated molecular patterns and cytokines. The second is the reperfusion phase, where the local ster… Show more
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