Liver involvement in inflammatory bowel disease: What should the clinician know?

Losurdo, Giuseppe; Brescia, Irene Vita; Lillo, Chiara; Mezzapesa, Martino; Barone, M.; Principi, Mariabeatrice; Ierardi, Enzo; Leo, Alfredo Di; Rendina, Maria

doi:10.4254/wjh.v13.i11.1534

Cited by 9 publications

(4 citation statements)

References 130 publications

(141 reference statements)

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“…PSC may occur years after colectomy for UC, and UC may first develop after liver transplantation has been performed for PSC. 11,32 First-degree relatives of patients with PSC have more chance to develop PSC and ulcerative colitis (UC), supporting a genetic basis to these conditions. 11 Our patients did not have any family history of PSC and ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

Primary Sclerosing Cholangitis in Very Early Age: Two Case Reports

Nahid,

Begum,

Alam

et al. 2023

Bangladesh J Child Health

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Primary Sclerosing Cholangitis (PSC) is a rare, chronic, progressive cholestatic liver disease which affects intrahepatic and extrahepatic bile ducts. That eventually progresses to end stage liver disease that requires liver transplantation. It mostly occurs in adolescent males and boys. Pediatric disease appears milder in contrast to adult-onset PSC. The diagnosis is made by Magnatic Resonance Cholangiopancreatography (MRCP). Though there is no practical guideline available in pediatric patients for treating PSC UDCA is prescribed chronically in over 80% of patients. There is close association of PSC with inflammatory bowel disease and autoimmune hepatitis in children. So the treatment is complex in case of children. We reported here two cases of PSC, because of rarity of this disease in such a young age. BANGLADESH J CHILD HEALTH 2022; VOL 46 (1) : 30-34

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Section: Discussionmentioning

confidence: 99%

Primary Sclerosing Cholangitis in Very Early Age: Two Case Reports

Nahid,

Begum,

Alam

et al. 2023

Bangladesh J Child Health

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“…Firstly, given the retrospective nature of the study, we cannot rule out possible biases related to data loss; furthermore, the wide observation period (2000–2013) may have led to non-homogeneous data collection over time. In addition, data on extraintestinal manifestations were not systematically available for all patients; though CD patients with liver involvement (such as primary sclerosing cholangitis) could have a phenotypical and clinical pattern that sharply differs from patients with CD alone [ 25 ]. For the abovementioned reason, we were not able to investigate this aspect in our series.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Surgical Recurrence in Patients with Crohn’s Disease on Long-Term Follow-Up: A Focus on Histology

Caviglia

Mineo

Rosso

et al. 2022

JCM

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In patients with Crohn’s disease (CD) that underwent surgery, predictive factors of surgical recurrence have been only partially identified. The aim of our study was to identify potential factors associated with an increased risk of surgical recurrence. A monocentric retrospective observational study was conducted including patients diagnosed with CD, according to ECCO criteria who received their first ileocolic resection. Overall, 162 patients were enrolled in our study; 54 of them were excluded due to a lack of sufficient data. The median follow-up was 136.5 months, IQR 91.5–176.5, and the surgical recurrence rate after the median follow-up was 21.3%. In the multivariate analysis, an age ≤ 28 years at the first surgical resection (aHR = 16.44, p < 0.001), current smoking (aHR = 15.84, p < 0.001), female sex (aHR = 7.58, p < 0.001), presence of granulomas at local lymph nodes (aHR = 12.19, p < 0.001), and treatment with systemic corticosteroids after the first surgical resection (aHR = 7.52, p = 0.002) were factors significantly associated with a risk of surgical recurrence, while cryptitis resulted in a protective factor (aHR = 0.02, p < 0.001). In conclusion, the heterogeneous spectrum of factors associated to the risk of surgical recurrence in patients with CD that underwent ileocolic resection supports the need of a personalized follow-up taking into account different clinical, surgical, and histologic features.

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“…Other research has shown that mice with increased human leukocyte antigen (HLA)-B27 fail to develop spondy-loarthritis when in a sterile environment, however this changes when commensal bacteria are introduced into their microbiome [24]. Beyond arthritis, IBD is associated with a variety of other autoimmune diseases including primary sclerosing cholangitis, type 1 diabetes (T1D), and even multiple sclerosis, all of which exhibit their own microbial alterations [25][26][27][28][29].…”

Section: -1950mentioning

confidence: 99%

The gut barrier and chronic diseases

Santilli

Stefanopoulos

Cresci

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewThe purpose of this review is to provide an update regarding the gut barrier and its involvement with chronic diseases, as well as to review biomarkers for identification of gut barrier integrity. This review is timely and relevant as our knowledge is increasing regarding the role of the gut microbiome and the gut barrier in health and disease. Recent findingsThis review provides an overview of: the gut barrier, which is complex and comprised of the mucus layer and the intestinal apical junctional protein complex; the gut microbiome in its relation to regulating the integrity of the gut barrier; select acute and chronic conditions that are known to be associated with gut dysbiosis and impaired gut integrity or 'leaky gut'; and current means for identifying loss in gut barrier integrity. SummaryMany chronic conditions are associated with gut dysbiosis and systemic inflammation. Identifying whether the gut barrier is compromised in these conditions could help to inform potential therapeutics as a means to correct losses in gut barrier integrity and mitigate associated medical conditions.

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Liver involvement in inflammatory bowel disease: What should the clinician know?

Cited by 9 publications

References 130 publications

Primary Sclerosing Cholangitis in Very Early Age: Two Case Reports

Primary Sclerosing Cholangitis in Very Early Age: Two Case Reports

Predictive Factors of Surgical Recurrence in Patients with Crohn’s Disease on Long-Term Follow-Up: A Focus on Histology

The gut barrier and chronic diseases

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