Liver immunology and herbal treatment

Balaban, Yasemin; Aka, Ceylan; Çalışkan, Ufuk Koca

doi:10.4254/wjh.v9.i17.757

Cited by 10 publications

(12 citation statements)

References 92 publications

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“…In this study, we found that AS-IV pretreatment (20 and 40 mg/kg) remarkably ameliorated APAP-induced liver injury, as evidenced by the reduced elevation of ALT and AST ( Figure 2 ), and the alleviated histological abnormalities ( Figure 3 ). There are an increasing number of studies showing that herbal medicines derived from plant extracts are being increasingly utilized to treat liver injury [ 14 , 15 ]. Plant extracts contribute to a variety of intracellular signaling cascades in hepatocyte to ameliorate inflammatory reactions.…”

Section: Discussionmentioning

confidence: 99%

Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway

Huang

Wang

et al. 2018

Molecules

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Acetaminophen (APAP) is a well-known antipyretic and analgesic drug. However, the accidental or intentional APAP overdose will induce liver injury and even acute liver failure. Astragaloside IV (AS-IV), a bioactive compound isolated from Astragali Radix, has been reported to have protective effects on the digestive and immune systems because of its anti-oxidant and anti-inflammatory properties. This study aims to observe whether AS-IV pretreatment provides protection against APAP-induced liver failure. The results of serum alanine/aspartate aminotransferases (ALT/AST) analysis, hepatic glutathione (GSH), and malondialdehyde (MDA) amounts, and liver superoxide dismutase (SOD) activity showed that AS-IV protected against APAP-induced hepatotoxicity. Liver histological observation further evidenced this protection provided by AS-IV. AS-IV was found to reverse the APAP-induced increased amounts of pro-inflammatory cytokines, including interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Western-blot analysis showed that AS-IV increased the transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and enhanced the expression of heme oxygenase 1 (HO-1) and reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H): quinone oxidoreductase 1 (NQO1) in the presence of APAP. AS-IV also decreased the expression of kelch-like ECH-associated protein-1 (Keap1). In conclusion, we demonstrated that AS-IV exerted a strong protection against APAP-induced hepatotoxicity by activating Nrf2 antioxidant signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway

Huang

Wang

et al. 2018

Molecules

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“… 24 GSH is the major nonenzymatic antioxidant and regulator of intracellular redox homeostasis in all cell types. 25 , 26 GSH depletion can increase the formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) such as superoxide anion, hydroxyl radical, and hydrogen peroxide and nitro oxide. Additional levels of ROS and RNS can attack biological molecules such as DNA, protein, which leads to lipid peroxidation, and depletion of the antioxidant enzymes that later cause severe oxidative stress, DNA strand breaks, apoptosis, and necrosis.…”

Section: Discussionmentioning

confidence: 99%

Cuscuta arvensisBeyr “Dodder”:In VivoHepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats

Çalışkan

Yılmaz

Taşlidere

et al. 2018

Journal of Medicinal Food

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Cuscuta arvensis Beyr. is a parasitic plant, and commonly known as “dodder” in Europe, in the United States, and “tu si zi shu” in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used as a folk medicine for the treatment particularly of liver problems, knee pains, and physiological hepatitis, which occur notably in newborns and their mothers in the southeastern part of Turkey. The purpose of this study was to investigate the hepatoprotective effects and antioxidant activities of aqueous and methanolic extracts of C. arvensis Beyr. on acetaminophen (APAP)-induced acute hepatotoxicity in rats. The results were supported by subsequent histopathological studies. The hepatoprotective activity of both the aqueous and methanolic extracts at an oral dose of 125 and 250 mg/kg was investigated by observing the reduction levels or the activity of alkaline phosphatase, alkaline transaminase, aspartate aminotransferase, blood urine nitrogen, and total bilirubin content. In vivo antioxidant activity was determined by analyzing the serum superoxide dismutase, malondialdehyde, glutathione, and catalase levels. Chromatographic methods were used to isolate biologically active compounds from the extract, and spectroscopic methods were used for structure elucidation. Both the methanolic and aqueous extracts exerted noticable hepatoprotective and antioxidant effects supporting the folkloric usage of dodder. One of the bioactive compounds was kaempferol-3-O-rhamnoside, isolated and identified from the methanolic extract.

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“…For example, silymarin has been found to significantly promote the survival period of alcoholic cirrhosis patients (139, 140). Further mechanism study indicated that flavonoids from Silybum marianum , including silybin and silymarin, could normalize immunoregulatory defects via restorating the cellular thiol status, inducing T-cell activation (CD69) with a significant reduction of TNF (139, 141). Although there is still a long way to go to fulfill the immunity treatment in ALD, it represents a very encouraging field for ALD therapy.…”

Section: Potential Therapeutic Approaches To Treat Ald Via Regulationmentioning

confidence: 99%

Recent Insights Into the Role of Immune Cells in Alcoholic Liver Disease

Tan

Wang

et al. 2019

Front. Immunol.

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Accumulating clinical and experimental evidences have demonstrated that both innate and adaptive immunity are involved in the pathogenesis of alcoholic liver disease (ALD), in which the role of immunity is to fuel the inflammation and to drive the progression of ALD. Various immune cells are implicated in the pathogenesis of ALD. The activation of innate immune cells induced by alcohol and adaptive immune response triggered by oxidative modification of hepatic constituents facilitate the persistent hepatic inflammation. Meanwhile, the suppressed antigen-presenting capability of various innate immune cells and impaired function of T cells may consequently lead to an increased risk of infection in the patients with advanced ALD. In this review, we summarized the significant recent findings of immune cells participating in ALD. The pathways and molecules involved in the regulation of specific immune cells, and novel mediators protecting the liver from alcoholic injury via affecting these cells are particularly highlighted. This review aims to update the knowledge about immunity in the pathogenesis of ALD, which may facilitate to enhancement of currently available interventions for ALD treatment.

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Liver immunology and herbal treatment

Cited by 10 publications

References 92 publications

Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway

Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway

Cuscuta arvensisBeyr “Dodder”:In VivoHepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats

Recent Insights Into the Role of Immune Cells in Alcoholic Liver Disease

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