Mesenchymal neoplasms of the gallbladder are rare and in particular leiomyomas of the gallbladder have been rarely reported, all of them in patients with immune system disorders. This is the first report in Spanish of a 23-year-old female patient with a gallbladder leiomyoma without associated immunodeficiency. The patient lacks a previous history of uterine leiomyoma or any other form of neoplasm. She refers several episodes of epygastralgia. A hydatic cyst led to an initial diagnosis and the gallbladder was removed by means of simple cholecystectomy. The abnormal macroscopic aspect of the sample prompted intraoperative biopsy which revealed a benign gallbladder angiomyoma. Subsequent immunohistochemical analysis of the resected sample yielded the diagnosis of intramural endocavitary leiomyoma negative for EBV and C-kit / CD-117. The patient has good general condition and remains asymptomatic 15 months after surgery.Key words: Leiomyoma. Gallbladder. Mesenchymal neoplasm. Cholecystectomy.
CASE REPORTA 23-year-old female patient who refers several episodes of epygastralgia of 4 or 5 months of evolution not related to food intake which improved after vomiting. In the personal history of the patient, we remark the use of oral contraceptives for a period of 3 years. Blood test shows leukocyte count of 3,570 x 10 9 /L, Hb 115 g/L and MCV of 78 fL. The rest of parameters showed normal values. The patient remains asymptomatic between the episodes and keeps normal bowel habits.Simple abdominal X-rays reveal heterogeneous calcifications of 4-5 cm in the hepatic flexure of the colon. Abdominal echography shows the formation of biliary mud and a heterogeneous, hyperechoic mass of 45 mm adjacent to the gallbladder compatible with a diagnosis of hydatic cyst. Although the patient cohabits with dogs in an endemic area of hydatosis as is Spain (1,2), and the initial diagnosis leads to such condition, serology for hydatosis is negative. Abdominal CT scan (Fig. 1) shows hepatomegaly and partially calcified SOL (Space Ocuppying Lesion) of 50 mm in segment 5 of rounded morphology, lobulated borders and smaller rounded masses in the periphery. The image is compatible with a hydatic cyst but we do not discard a differential diagnosis with partially calcified hemangioma. The gallbladder presents with several microlithiasis without signs of inflammation. The CT scan also reveals a hemangioma of 31 mm in segment 4 as well as cortical cysts in both kidneys.The patient undergoes cholecystectomy and cystopericystectomy for suspected hydatic cyst and cholelithiasis. A right subcostal laparatomy is carried out. The gallbladder presents with an intravesicular tumor of petreous consistency which does not infiltrate the hepatic parenchyma (Fig. 2), and shows no SOL in segment 5. Intraoperative biopsy of the mass yields a diagnosis of benign gallbladder angiomyoma recommending simple cholecystectomy to